D- and Unnatural Amino Acid Substituted Antimicrobial Peptides With Improved Proteolytic Resistance and Their Proteolytic Degradation Characteristics [PDF]
Frontiers in Microbiology, 2020 The transition of antimicrobial peptides (AMPs) from the laboratory to market has been severely hindered by their instability toward proteases in biological systems.
Jianguang Lu +10 more
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Unnatural Amino Acid: 4-Aminopyrazolonyl Amino Acid Comprising Tri-Peptides Forms Organogel With Co-Solvent (EtOAc:Hexane) [PDF]
Frontiers in Chemistry, 2022 Ampyrone is an amino-functionalized heterocyclic pyrazolone derivative that possesses therapeutic values such as analgesic, anti-inflammatory, and antipyretics.
Amarnath Bollu +9 more
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5-Amino-3-methyl-Isoxazole-4-carboxylic Acid as a Novel Unnatural Amino Acid in the Solid Phase Synthesis of α/β-Mixed Peptides [PDF]
Molecules, 2022 The hybrid peptides consisting of α and β-amino acids show great promise as peptidomimetics that can be used as therapeutic agents. Therefore, the development of new unnatural amino acids and the methods of their incorporation into the peptide chain is ...
Urszula Bąchor +3 more
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An Unnatural Amino Acid-Regulated Growth Controller Based on Informational Disturbance [PDF]
Life, 2021 We designed a novel growth controller regulated by feeding of an unnatural amino acid, Nε-benzyloxycarbonyl-l-lysine (ZK), using a specific incorporation system at a sense codon. This system is constructed by a pair of modified pyrrolisyl-tRNA synthetase
Yusuke Kato
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A linear DNA template-based framework for site-specific unnatural amino acid incorporation [PDF]
Synthetic and Systems Biotechnology, 2021 Site-specific incorporation of unnatural amino acids (UNAAs) into proteins using an orthogonal translation system (OTS) has expanded the scope of protein-coding chemistry. The key factor affecting UNAA embedding efficiency is the orthogonality of the OTS.
Xinjie Chen +3 more
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Unnatural amino acid substitutions to improve in vivo stability and tumor uptake of 68Ga-labeled GRPR-targeted TacBOMB2 derivatives for cancer imaging with positron emission tomography [PDF]
EJNMMI Radiopharmacy and ChemistryBackground Overexpressed in various solid tumors, gastrin-releasing peptide receptor (GRPR) is a promising cancer imaging marker and therapeutic target. Although antagonists are preferable for the development of GRPR-targeted radiopharmaceuticals due to ...
Lei Wang +9 more
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An unnatural amino acid dependent, conditional Pseudomonas vaccine prevents bacterial infection [PDF]
Nature CommunicationsLive vaccines are ideal for inducing immunity but suffer from the need to attenuate their pathogenicity or replication to preclude the possibility of escape.
Michael Pigula +6 more
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Discovery of Staircase Chirality through the Design of Unnatural Amino Acid Derivatives [PDF]
ResearchChirality has garnered significant attention in the scientific community since its discovery by Louis Pasteur over a century ago. It has been showing a profound impact on chemical, biomedical, and materials sciences. Significant progress has been made in
Anis U. Rahman +9 more
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Fermentative production of the unnatural amino acid l-2-aminobutyric acid based on metabolic engineering [PDF]
Microbial Cell Factories, 2019 Background l-2-aminobutyric acid (l-ABA) is an unnatural amino acid that is a key intermediate for the synthesis of several important pharmaceuticals.
Jian-Miao Xu +4 more
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Investigating Macrolactone Formation by Thioesterase Domains through Incorporation of an Unnatural Amino Acid [PDF]
Structural DynamicsVishakha Choudhary, Tyler M. McCullough, David L. Akey, Meredith A. Skiba, Steffen M. Bernard, Jeffrey D. Kittendorf, Jennifer J. Schmidt, David H. Sherman and Janet L.
Vishakha Choudhary +2 more
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