Results 171 to 180 of about 1,288,650 (300)

Copper‐Doped Prussian Blue Nanozymes With Hyaluronic Acid‐Mediated Targeting Alleviate Oxidative Stress and Regulate Cholesterol Handling for Atherosclerosis Therapy

Advanced Science, EarlyView.
CuPB@HA is a CD44‐associated, plaque‐targeted nanozyme that alleviates oxidative stress, inflammation, and lipid accumulation in macrophages. By reducing CD36‐dependent lipid uptake and promoting ABCA1/ABCG1‐mediated cholesterol handling, it improves macrophage function, preferentially accumulates in atherosclerotic lesions, reduces plaque burden, and ...
Jianliang Ou, Ruihua Ji, Qinglu Zang, Mingkang Wang, Lingling Zhou, Yingliang Wei, Di Yang, Yue Wu, Hongxu Zhu, Jianrong Wu, Xiaojun Cai, Wenxian Du, Junjie Cheng, An Zeng, Yuehua Li   +14 more
wiley   +1 more source

Expedient Synthesis of <i>N</i>-Protected/<i>C</i>-Activated Unnatural Amino Acids for Direct Peptide Synthesis. [PDF]

J Am Chem Soc
Kohnke P, Zhang L.
europepmc   +1 more source

Using unnatural amino acids to selectively label proteins for cellular imaging: a cell biologist viewpoint. [PDF]

FEBS J, 2021
Elia N.
europepmc   +1 more source

Single‐Cell Transcriptomics and Metabolomics Reveal Glutamate Dehydrogenase as a Central Regulator of Nitrogen Metabolic Remodeling During Alkalinity Adaptation in Crustaceans

Advanced Science, EarlyView.
Single‐cell transcriptomics reveals the cellular response of Macrobrachium hainanense to carbonate alkalinity stress. Alkalinity stress impairs branchial ammonia excretion, induces mitochondrial dysfunction, and drives cell‐type‐specific changes in gills and hemocytes.
Yiting Jin, Zhimin Lv, Chao Bian, Qibin Yang, Na Zhou, Jianguang Qin, Shengming Sun   +6 more
wiley   +1 more source

Expanding the fluorescence toolkit: molecular design, synthesis and biological application of unnatural amino acids. [PDF]

Chem Sci
Marshall O, Sutherland A.
europepmc   +1 more source

Synthesis, Antitumor and Antibacterial Studies of New Shortened Analogues of (KLAKLAK)₂-NH₂ and Their Conjugates Containing Unnatural Amino Acids. [PDF]

Molecules, 2021
Jaber S, Iliev I, Angelova T, Nemska V, Sulikovska I, Naydenova E, Georgieva N, Givechev I, Grabchev I, Danalev D.   +9 more
europepmc   +1 more source

Determination of D-amino-acid residues in peptides from animal venom by NMR : application to platypus venom peptide OvCNPs

, 2009
D-Amino acids are stereoisomers or optical isomers of naturally occurring L-amino acids. D Amino acids and L-amino acids have almost the same physical and chemical properties.
Geraghty, Dominic P., Bansal, Paramjit S., Alewood, Paul F., Torres, Allan M. (R11665), Kuchel, Philip W.   +4 more
core  

Sonoselective Transfection of Glioma Endothelium

Advanced Science, EarlyView.
Delivering non‐viral, gene‐bearing nanoparticles with thiol‐decorated surfaces to gliomas with focused ultrasound yields transfection tropism for endothelial cells. From this platform, “sonoselective” transfection of glioma endothelium is achieved via incorporation of an endothelial cell‐specific promoter.
Anna C. Debski, Catherine M. Gorick, Victoria R. Breza, Jackson Tirrell, Krishan Perumal, Katherine M. Nowak, Ji Song, Natasha D. Sheybani, Richard J. Price   +8 more
wiley   +1 more source

Predicting the structures of cyclic peptides containing unnatural amino acids by HighFold2. [PDF]

Brief Bioinform
Zhu C, Cao S, Shang T, Guo J, Su A, Li C, Duan H.   +6 more
europepmc   +1 more source

Chimeric IL‐6/4R‐LL37 Engineered Macrophages Achieve Synchronized Inflammation Control and Antimicrobial Defence in Sepsis

Advanced Science, EarlyView.
Engineered macrophages programmed in situ by LNP‐delivered IL‐6/4 fusion and LL37 mRNAs simultaneously dampen cytokine storm, promote M2‐like repair, and enhance direct bacterial killing in sepsis. This combinatorial strategy restores T cell and macrophage function, lowers organ bacterial burden, and improves survival, highlighting a precision, host ...
Tianyang Jie, Zheyu Zhang, Hao Zhang, Linke Bian, Penglong Zheng, Sijia Zhou, Minqi Wang, Mingyu Qu, Yufei Wang, Xinhua Qu, Bing Yue   +10 more
wiley   +1 more source