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AHR‐Responsive Carbon Dots Orchestrate Skin Wound Healing and Colonic Mucosal Repair via Treg‐Mediated Macrophage Efferocytosis

Advanced Science, EarlyView.
Guided by pharmacophore modeling and molecular docking, aryl hydrocarbon receptor (AHR)‐responsive carbon dots were synthesized. They bind directly to AHR and expand gut‐resident regulatory T (Treg) cells. Treg‐derived C‐C motif chemokine ligand 1 (CCL1) enhances macrophage efferocytosis, creating a pro‐regenetative niche that promotes colonic mucosal ...
Zilu Zhu, Han Zhang, Shuai Lin, Wenqian Zheng, Xin Li, Xiaowei Xu, Ruili Yang   +6 more
wiley   +1 more source

Preparative deracemization of unnatural amino acids

Biochemical Society Transactions, 2006
Unnatural amino acids are a growing class of intermediates required for pharmaceuticals, agrochemicals and other industrial products. However, no single method has proven sufficiently versatile to prepare these compounds broadly at scale. To address this need, we have developed a general chemoenzymatic process to prepare enantiomerically pure L- and D ...
Fotheringham, I, Archer, I, Carr, R, Speight, R, Turner, NJ   +4 more
openaire   +5 more sources

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Applications of Unnatural Amino Acids in Protease Probes

Chemistry - an Asian Journal, 2019
AbstractSince proteases are involved in a wide range of physiological and disease states, the development of novel tools for imaging proteolytic enzyme activity is attracting increasing interest from scientists. Peptide substrates containing proteinogenic amino acids are often the first line of defining enzyme specificity.
Marcin Drąg, Izabela Małuch
exaly   +3 more sources

NMR Analysis of Unnatural Amino Acids in Natural Antibiotics

, 2011
A large number of modified amino acids other than the canonical amino acid residues can be found in natural products, especially antibiotics. The structure of these peptide-based compounds is investigated using modern two-dimensional NMR techniques. The automatic assignment of the 2D NMR proton spectra and consequent determination of the primary and 3D
Castiglione F., Franca Castiglione
openaire   +4 more sources

An unnatural amino acid that mimics phosphotyrosine

Chemical Communications, 2010
By replacing the phosphate group in pTyr with an isoxazole carboxylic acid, a novel unnatural amino acid has been successfully synthesized. Subsequently, its incorporation into a known PPI (protein-protein interaction) inhibitor of STAT3 protein (ISS 610) generated I2 which showed reasonable anti-STAT3 activity in both fluorescence polarization and ...
Ge, J., Wu, H., Yao, S.Q.
openaire   +2 more sources

Unnatural amino acids as probes of protein structure and function

Current Opinion in Chemical Biology, 2000
Nonsense suppression methodology, for incorporating unnatural amino acids into proteins, has enabled a wide range of studies into protein structure and function using both in vitro and in vivo translation systems.
Dennis A. Dougherty
exaly   +1 more source

Antibody Conjugates with Unnatural Amino Acids

Molecular Pharmaceutics, 2015
Antibody conjugates are important in many areas of medicine and biological research, and antibody-drug conjugates (ADCs) are becoming an important next generation class of therapeutics for cancer treatment. Early conjugation technologies relied upon random conjugation to multiple amino acid side chains, resulting in heterogeneous mixtures of labeled ...
Trevor J, Hallam, Erik, Wold, Alan, Wahl, Vaughn V, Smider   +3 more
openaire   +2 more sources

Regulation of transcription by unnatural amino acids

Nature Biotechnology, 2011
Small-molecule regulation of gene expression is intrinsic to cellular function and indispensable to the construction of new biological sensing, control and expression systems. However, there are currently only a handful of strategies for engineering such regulatory components and fewer still that can give rise to an arbitrarily large set of inducible ...
Chang C, Liu, Lei, Qi, Charles, Yanofsky, Adam P, Arkin   +3 more
openaire   +2 more sources

Synthesis of Unnatural Amino Acids

ChemInform, 2005
AbstractFor Abstract see ChemInform Abstract in Full Text.
David J. Ager, Scott A. Laneman
openaire   +1 more source

The unnatural culture of amino acids

Nature Methods, 2007
Researchers describe a general and highly efficient approach for incorporating a variety of unnatural amino acids into proteins at desired locations in mammalian cells.
Corinne D Hausmann, Jiqiang Ling, Michael Ibba   +2 more
openaire   +1 more source