Results 61 to 70 of about 834,880 (297)

Targeting TNBC: core–shell polycationic polyurea dendrimers with inherent anticancer activity

FEBS Open Bio, EarlyView.
Core–shell polycationic PURE dendrimers were tested in TNBC‐derived tumor models. Both formulations selectively targeted TNBC and effectively reduced tumor volume. PUREG4‐OEI48 suppressed tumor growth without detectable toxicity, whereas PUREG4‐OCEI24, despite showing efficacy, induced hepatic toxicity.
Adriana Cruz, Bruna Abreu, Cindy Mendes, Catarina Freitas‐Dias, Filipe Gonçalves, Fernanda Silva, José Ramalho, Saudade André, Vasco D. B. Bonifácio, Jacinta Serpa   +9 more
wiley   +1 more source

Influence of type A behavioral activity on the development of cardiovascular disease

КардиоСоматика, 2019
Aim. To study the influence of type of behavioral activity on the development of cardiovascular diseases, to evaluate the effect of type of behavior on the frequency of repeated hospitalizations and fatal outcomes after acute coronary syndrome. Materials
Anatoly I. Martynov, Evgeniya V. Akatova, Elena I. Pervichko, Olesya P. Nikolin, Inna V. Urlaeva   +4 more
doaj   +1 more source

Actively Contracting Bundles of Polar Filaments

, 2000
We introduce a phenomenological model to study the properties of bundles of polar filaments which interact via active elements. The stability of the homogeneous state, the attractors of the dynamics in the unstable regime and the tensile stress generated
A. A. Hyman, A. B. Verkhovsky, B. Alberts, F. C. MacKintosh, F. J. Nédélec, F. Jülicher, H. Nakazawa, J. Howard, K. Sekimoto, K. Takiguchi, O. Thoumine, T. Kreis, T. Surrey   +12 more
core   +1 more source

Stability of degenerate Cauchy horizons in black hole spacetimes [PDF]

, 1998
In the multihorizon black hole spacetimes, it is possible that there are degenerate Cauchy horizons with vanishing surface gravities. We investigate the stability of the degenerate Cauchy horizon in black hole spacetimes.
A. Bonanno, A. Ori, A. Ori, C. Gundlach, C. Gundlach, C. M. Chambers, D. A. Konkowski, D. Klemm, D. Marković, D. Marković, E. Poisson, F. Mellor, F. Mellor, J. S. F. Chan, J. S. F. Chan, J. T. Wheeler, L. M. Burko, L. M. Burko, N. D. Birrell, P. R. Brady, P. R. Brady, P. R. Brady, P. R. Brady, P. R. Brady, P. R. Brady, R. A. Matzner, R. Balbinot, R. C. Myers, R. G. Cai, R. G. Cai, R. H. Price, R. H. Price, R. Penrose, Rong-Gen Cai, S. Chandrasekhar, S. Hod, S. J. Avis, W. A. Hiscock   +37 more
core   +2 more sources

Evolutionarily divergent DUF4465 domains have a common vitamin B12‐binding function

FEBS Open Bio, EarlyView.
We show that DUF4465 family proteins, widespread across bacteria from gut microbiomes, hydrothermal vents, and soil, share a common vitamin B12‐binding function. These augmented β‐jellyroll proteins bind vitamin B12 via extended loops. Our findings establish sequence‐diverse DUF4465 proteins as a widespread class of B12‐binding proteins, highlighting ...
Charlea Clarke, Michal Banasik, Rokas Juodeikis, Martin J. Warren, Richard W. Pickersgill   +4 more
wiley   +1 more source

The Effect of Cognitive Task on Postural Control Dynamic Regularity of Athletes With Chronic Ankle Instability When Standing on an Unstable Surface

Function and Disability Journal, 2020
Background and Objectives: Postural control disorder is a common complication in patients with Chronic Ankle Instability (CAI). The present study aimed to investigate the effect of dual cognitive task on postural control behavior with regard to the ...
Ghadir Abolghasemi, Soheil Mansour Sohani, Esmaeel Ebrahimi Takamjani , Shahab Asgari, Reza Salehi   +4 more
doaj   +1 more source

Breakdown of the standard Perturbation Theory and Moving Boundary Approximation for "Pulled" Fronts [PDF]

, 2000
The derivation of a Moving Boundary Approximation or of the response of a coherent structure like a front, vortex or pulse to external forces and noise, is generally valid under two conditions: the existence of a separation of time scales of the dynamics
Ebert, Ute, van Saarloos, Wim
core   +4 more sources

Identifying gene expression signatures for risk stratification of postoperative adjuvant chemotherapy in colorectal cancer

FEBS Open Bio, EarlyView.
A novel signature integrating genome‐wide analysis with clinical factors predicts recurrence in stage II colorectal cancer and enables a new risk stratification to guide postoperative adjuvant chemotherapy. Clinical risk stratification for postoperative recurrence in patients with pathological stage II (pStage II) colorectal cancer (CRC) is essential ...
Mayuko Otomo, Keisuke Okuno, Shuichi Watanabe, Sakiko Oba, Hiroyasu Kagawa, Masanori Tokunaga, Daisuke Ban, Yusuke Kinugasa   +7 more
wiley   +1 more source

Anharmonic effects in the A15 compounds induced by sublattice distortions

, 1997
We demonstrate that elastic anomalies and lattice instabilities in the the A15 compounds are describable in terms of first-principles LDA electronic structure calculations.
B. M. Klein, B. P. Schweiss, Barry M. Klein, E. K. H. Salje, G. Shirane, K. J. Kingma, L. F. Mattheiss, L. Pintschovius, L. R. Testardi, L. R. Testardi, M. J. Mehl, M. Rosen, M. Weger, P. B. Miller, W. E. Pickett, Yu. A. Izyumov, Z. W. Lu   +16 more
core   +1 more source

Two-dimensional global manifolds of vector fields [PDF]

, 1998
We describe an efficient algorithm for computing two-dimensional stable and unstable manifolds of three-dimensional vector fields. Larger and larger pieces of a manifold are grown until a sufficiently long piece is obtained.
Back A., Bernd Krauskopf, Hinke Osinga, Phillips M.   +3 more
core   +2 more sources