Results 41 to 50 of about 246,994 (340)

The androgen receptor messenger RNA: what do we know?

RNA Biology, 2022
The Androgen Receptor (AR), transcriptionally activated by its ligands, testosterone and dihydrotestosterone (DHT), is widely expressed in cells and tissues, influencing normal biology and disease states. The protein product of the AR gene is involved in
Eviania Likos, Asmita Bhattarai, Crystal M. Weyman, Girish C. Shukla   +3 more
doaj   +1 more source

Simple sequence repeats in zebra finch (Taeniopygia guttata) expressed sequence tags: a new resource for evolutionary genetic studies of passerines [PDF]

, 2007
Background Passerines (perching birds) are widely studied across many biological disciplines including ecology, population biology, neurobiology, behavioural ecology and evolutionary biology.
Birkhead, T.R., Hale, M.C., Slate, J.
core   +2 more sources

Frequent mutation of the FOXA1 untranslated region in prostate cancer [PDF]

Communications Biology, 2018
AbstractProstate cancer has a low somatic mutation rate but non-coding regions remain underexplored. We sequenced the untranslated regions (UTRs) of 72 established driver genes in 428 patients with metastatic prostate cancer and identified FOXA1 3′-UTR mutations in 12% of patients.
Matti Annala, Matti Annala, Kevin Beja, Alexander W. Wyatt, Matti Nykter, Jack V. W. Bacon, Sinja Taavitsainen, Kim N. Chi, Gillian Vandekerkhove   +8 more
openaire   +4 more sources

Statistical analysis supports UTR (untranslated region) deletion theory in SARS-CoV-2

Virulence, 2022
It was noticed that the mortality rate of SARS-CoV-2 infection experienced a significant declination in the early stage of the epidemic. We suspect that the sharp deterioration of virus toxicity is related to the deletion of the untranslated region (UTR)
Zhaobin Xu, Dongying Yang, Liyan Wang, Jacques Demongeot   +3 more
doaj   +1 more source

The potential for reassortment between Oropouche and Schmallenberg Orthobunyaviruses [PDF]

, 2017
A number of viruses within the Peribunyaviridae family are naturally occurring reassortants, a common phenomenon for segmented viruses. Using a minigenome-reporter and virus-like particle (VLP) production assay, we have accessed the potential of ...
Elliott, Richard M., Olszanski Acrani, Gustavo, Shi, Xiaohong, Tilston-Lunel, Natasha L.   +3 more
core   +1 more source

Expression of distinct RNAs from 3′ untranslated regions [PDF]

Nucleic Acids Research, 2010
The 3' untranslated regions (3'UTRs) of eukaryotic genes regulate mRNA stability, localization and translation. Here, we present evidence that large numbers of 3'UTRs in human, mouse and fly are also expressed separately from the associated protein-coding sequences to which they are normally linked, likely by post-transcriptional cleavage.
T. Mercer, D. Wilhelm, M. Dinger, G. Solda, D. Korbie, E. Glazov, V. Truong, M. Schwenke, C. Simons, K. Matthaei, R. Saint, P. Koopman, J. S. Mattick   +12 more
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Massively parallel functional annotation of 3′ untranslated regions [PDF]

Nature Biotechnology, 2014
Functional characterization of noncoding sequences is crucial for understanding the human genome and learning how genetic variation contributes to disease. 3' untranslated regions (UTRs) are an important class of noncoding sequences, but their functions remain largely uncharacterized.
Zhao, Wenxue, Pollack, Joshua L, Blagev, Denitza P, Zaitlen, Noah, McManus, Michael T, Erle, David J   +5 more
openaire   +5 more sources

High-Level Expression of Various Apolipoprotein (a) Isoforms by "Transferrinfection". The Role of Kringle IV Sequences in the Extracellular Association with Low-Density Lipoprotein [PDF]

, 1994
Characterization of the assembly of lipoprotein(a) [Lp(a)] is of fundamental importance to understanding the biosynthesis and metabolism of this atherogenic lipoprotein. Since no established cell lines exist that express Lp(a) or apolipoprotein(a) [apo(a)
Azrolan N., Boerwinkle E., Brunner C., Chiesa G., Chung B. Y., Cotten M., Deutscher S. L., Deutscher S. L., Dieplinger H., Edelberg J. M., Green S., Griffiths G., Guevara J., Jr., Huby T., Ichinose A., Kamboh M. I., Koschinsky M. L., Koschinsky M. L., Koschinsky M. L., Kostner G. M., Kraft H- G., Kraft H. G., Krempler F., Krempler F., Lackner C., Linton M. F., Malgaretti N., McGregor G. R., McLean J. W., Menzel H. J., Phillips M. L., Rader D. J., Sambrook J., Sandholzer C., Scanu A. M., Selden R. F., Sommer A., Stanley P., Trieu V. N., Utermann G., Utermann G., Utermann G., Wagner E., White A. L., Zatloukal K., Zechner R„   +45 more
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Novel Dengue Virus Type 1 from Travelers to Yap State, Micronesia

Emerging Infectious Diseases, 2006
Dengue virus type 1 (DENV-1), which was responsible for the dengue fever outbreak in Yap State, Micronesia, in 2004, was isolated from serum samples of 4 dengue patients in Japan. Genome sequencing demonstrated that this virus belonged to genotype IV and
Yoko Nukui, Shigeru Tajima, Akira Kotaki, Mikako Ito, Tomohiko Takasaki, Kazuhiko Koike, Ichiro Kurane   +6 more
doaj   +1 more source

The RNA Architecture of the SARS-CoV-2 3′-Untranslated Region

Viruses, 2020
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is responsible for the current COVID-19 pandemic. The 3′ untranslated region (UTR) of this β-CoV contains essential cis-acting RNA elements for the viral genome transcription and replication ...
Junxing Zhao, Jianming Qiu, Sadikshya Aryal, Jennifer L. Hackett, Jingxin Wang   +4 more
doaj   +1 more source