DNA methylation at the DAT promoter and risk for psychopathology. Intergenerational transmission between school-age youths and their parents in a community sample [PDF]
, 2018 Background: The effect of gene polymorphisms and promoter methylation, associated with maladaptive developmental outcomes, vary depending on environmental factors (e.g., parental psychopathology).
Claudio D’Addario +9 more
core +2 more sources
Spatial preferences of microRNA targets in 3' untranslated regions [PDF]
BMC Genomics, 2007 MicroRNAs are an important class of regulatory RNAs which repress animal genes by preferentially interacting with complementary sequence motifs in the 3' untranslated region (UTR) of target mRNAs. Computational methods have been developed which can successfully predict which microRNA may target which mRNA on a genome-wide scale.We address how predicted
William H. Majoros, Uwe Ohler
openaire +4 more sources
Recombinants between Deformed wing virus and Varroa destructor virus-1 may prevail in Varroa destructor-infested honeybee colonies [PDF]
, 2011 We have used high-throughput Illumina sequencing to identify novel recombinants between deformed wing virus (DWV) and Varroa destructor virus-1 (VDV-1), which accumulate to higher levels than DWV in both honeybees and Varroa destructor mites.
A. Jironkin +20 more
core +1 more source
Translational medicine: untranslated regions and the stop codons [PDF]
Bulletin of Russian State Medical University, 2016 4P medicine is impossible without an efficient transfer of advanced laboratory techniques (such as regenerative cell technology, high-throughput sequencing, genome editing, etc.) into clinical practice. Translational Medicine a new scientific field, designed to reduce the time of transfer of long-term achievements of fundamental scientific research in ...
REBRIKOV D.V., TARASOV V.V.
openaire +3 more sources
Mapping the Pax6 3’ untranslated region microRNA regulatory landscape
BMC Genomics, 2018 Background PAX6 is a homeodomain transcription factor that acts in a highly dosage-sensitive manner to regulate the development and function of the eyes, nose, central nervous system, gut, and endocrine pancreas. Several individual microRNAs (miRNA) have
Bridget C. Ryan +6 more
doaj +1 more source
Smad3 Regulates Neuropilin 2 Transcription by Binding to its 5′ Untranslated Region
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2020 Background Vascular smooth muscle cell phenotypic change and consequential intimal hyperplasia (IH) cause arterial stenosis and posttreatment restenosis.
Xiujie Xie +5 more
doaj +1 more source
MicroRNA genes and their target 3'-untranslated regions are infrequently somatically mutated in ovarian cancers. [PDF]
PLoS ONE, 2012 MicroRNAs are key regulators of gene expression and have been shown to have altered expression in a variety of cancer types, including epithelial ovarian cancer.
Georgina L Ryland +9 more
doaj +1 more source
Chimerization of antibodies by isolation of rearranged genomic variable regions by the polymerase chain reaction [PDF]
, 1991 We describe a new method for amplification, by polymerase chain reaction (PCR), of rearranged segments encoding the variable part of light and heavy chains of an antibody (Ab) from the chromosomal DNA of hybridoma cells for the chimerization ofAbs.
Kaluzab, Brigitte +4 more
core +1 more source
Transcriptional Repression, a Novel Function for 3' Untranslated Regions [PDF]
European Journal of Biochemistry, 1995 The transcription rates of the rat serine protease inhibitor 2.3 and 2.1 genes (spi 2.3 and spi 2.1), which are normally very low and high, respectively, are inversely modulated during inflammation. Two growth‐hormone‐response elements (GHRE‐I and GHRE‐II) maintain the spi 2.1 gene under the stringent control of growth hormone [Le Cam, A., Pantescu, V.,
Catherine Legraverend, Alphonse Le Cam
openaire +4 more sources
Inhibition of SARS-CoV-2 by Targeting Conserved Viral RNA Structures and Sequences
Frontiers in Chemistry, 2021 The ongoing COVID-19/Severe Acute Respiratory Syndrome CoV-2 (SARS-CoV-2) pandemic has become a significant threat to public health and has hugely impacted societies globally.
Shalakha Hegde +3 more
doaj +1 more source