Results 81 to 90 of about 32,245 (190)

Bisphenol A Induces DNA Damage and Differential Cytotoxicity in Thyroid Cells: High‐Dose Effects Challenge Regulatory Thresholds

Journal of Applied Toxicology, EarlyView.
ABSTRACT Bisphenol A (BPA), a ubiquitous environmental endocrine disruptor, has been implicated in carcinogenesis; however, its effects on thyroid cells remain unclear. This study investigated BPA‐induced cytotoxicity and genotoxicity in thyroid cell lines, including normal follicular (Nthy‐ori 3‐1), papillary carcinoma (TPC‐1 and BCPAP) and anaplastic
Izabela Fernanda Dal' Bó, Natássia Elena Bufalo, Valdemar Máximo, Laura Sterian Ward   +3 more
wiley   +1 more source

Cellular Responses to Tartrazine and Sulfanilic Acid Exposure in BEAS‐2B Cells: Viability, Apoptosis, and DNA Damage

Journal of Applied Toxicology, EarlyView.
ABSTRACT Tartrazine is a synthetic azo dye widely used in food, pharmaceutical, and cosmetic products, resulting in extensive human exposure, while its toxicity and that of its primary metabolite, sulfanilic acid, remain controversial. Considering the reported association of tartrazine with hypersensitivity and allergic‐like reactions, human bronchial ...
Merve Baysal, Abdullah Burak Karaduman, Büşra Korkut Çelikateş, Merve Güven, Özlem Atlı‐Eklioğlu, Sinem Ilgın   +5 more
wiley   +1 more source

Different Levels, Same Relations? A Meta‐Analysis on the Homology of the Nomological Network of (Daily) Work Engagement

Journal of Organizational Behavior, EarlyView.
ABSTRACT Work engagement has garnered significant attention from researchers and practitioners in recent decades, and several meta‐analyses have examined its stable, between‐person correlates. However, work engagement also has a dynamic component, meaning that it varies daily, across situations, and within individuals.
Jan Luca Pletzer, Nadine Planken, Kimberley Breevaart, Despoina Xanthopoulou, Arnold B. Bakker   +4 more
wiley   +1 more source

Oncogenic KRAS Rewires Stress Granule Dynamics: Mechanisms and Therapeutic Opportunities

The Kaohsiung Journal of Medical Sciences, EarlyView.
ABSTRACT Stress granules (SGs) are dynamic, membrane‐less structures that form in response to various cellular stresses, including metabolic, oxidative, and therapeutic challenges. They function as adaptive hubs and reorganize protein synthesis and signaling networks to help cells survive under stress. In cancer, these condensates are often hijacked to
Msimisi Ndzinisa, Birhanetensay Masresha Altaye, Yuh‐Pyng Sher   +2 more
wiley   +1 more source

Mechanism of DNA unwinding by MCM8-9 in complex with HROB

Nature Communications
HROB promotes the MCM8-9 helicase in DNA damage response. To understand how HROB activates MCM8-9, we defined their interaction interface. We showed that HROB makes important yet transient contacts with both MCM8 and MCM9, and binds the MCM8-9 ...
Ananya Acharya, Hélène Bret, Jen-Wei Huang, Martin Mütze, Martin Göse, Vera Maria Kissling, Ralf Seidel, Alberto Ciccia, Raphaël Guérois, Petr Cejka   +9 more
doaj   +1 more source

LPCAT3 as a Potential Drug Target for Ultraviolet Radiation–Induced Cataract: Insights From Multiomics Analysis

The Kaohsiung Journal of Medical Sciences, EarlyView.
ABSTRACT Ultraviolet B (UVB) radiation is a major risk factor for cataract development, but the molecular mechanisms underlying this process, particularly the involvement of regulated cell death pathways such as ferroptosis, remain unclear. Transcriptomic, proteomic, and metabolomic analyses were performed on lens tissues from UVB‐induced cataract rat ...
Fei Xu, Xiao‐Bo Wan, Yong‐Shun Liang, Tian Lan, Hao Liang   +4 more
wiley   +1 more source

Pancharatnam–Berry Phase Driven by Electrical Restructuring of Liquid Crystal Polarization Grating Period

Laser &Photonics Reviews, EarlyView.
Electrically controlled liquid‐crystal twist diffraction element based on the Pancharatnam–Berry phase enables switchable structural periodicity and simultaneous generation of orthogonal circularly polarized coherent waves for multifunctional planar photonic devices.
Elena Melnikova, Katsiaryna Pantsialeyeva, Alexei Tolstik, Veranika Stanevich, Daminika Dashkevich, Anatoli Murauski, Alexander Muravsky, Alina Karabchevsky   +7 more
wiley   +1 more source

Optical mapping reveals a higher level of large‐scale structural variants in a family with paternally transmitted myotonic dystrophy and independent Parkinson's disease

The Journal of Pathology, EarlyView.
Abstract Myotonic dystrophy type 1 (DM1) is a clinically challenging multisystem neuromuscular hereditary disorder, with generational increase in severity and earlier age at onset. It is caused by an unstable cytosine‐thymine‐guanine repeat expansion at the DMPK locus, accompanied by associated genetic and epigenetic modifications.
Md Mehedi Hasan, Jenna Craddock, Tingting Gong, Ruth J Lyons, Igor Stevanovski, Sanjog R Chintalaphani, Ira W Deveson, Weerachai Jaratlerdsiri, Kishore R Kumar, Vanessa M Hayes   +9 more
wiley   +1 more source

Enzymatic characterization and dominant sites of foot-and-mouth disease virus 2C protein

Heliyon
Foot-and-mouth disease virus (FMDV) 2C protein is a conserved non-structural protein and crucial for replication of the virus. In this study, FMDV 2C protein was prepared and the enzymatic activities were investigated in detail.
Saisai Zhou, Nankun Liu, Yang Tian, Hong Pan, Yang Han, Zhen Li, Jinhua Zhang, Shuaiyin Guan, Huanchun Chen, Yunfeng Song   +9 more
doaj   +1 more source

Virtual Elastic Tether: A New Approach for Multi‐Agent Navigation in Confined Aquatic Environments

Journal of Field Robotics, EarlyView.
ABSTRACT Underwater navigation is a challenging area in the field of mobile robotics due to inherent constraints in self‐localization and communication in underwater environments. Some of these challenges can be mitigated by using collaborative multi‐agent teams.
Kanzhong Yao, Xueliang Cheng, Keir Groves, Barry Lennox, Ognjen Marjanovic, Simon Watson   +5 more
wiley   +1 more source