Results 91 to 100 of about 8,219 (198)

Efficacy and Field Safety of the Second‐Generation, Highly Selective JAK1 Inhibitor Atinvicitinib for the Treatment of Canine Atopic Dermatitis: A Multicentre, Blinded, Randomised, Placebo‐Controlled Clinical Trial in Client‐Owned Dogs

open access: yesVeterinary Dermatology, EarlyView.
Background: Janus kinase (JAK) inhibitors alleviate pruritus and clinical signs of canine atopic dermatitis (cAD). Objective: To confirm the optimal dosing regimen of atinvicitinib, a second‐generation highly selective inhibitor of JAK1 in dogs. Conclusions and Clinical Relevance: Once‐daily atinvicitinib was safe, well‐tolerated and effective at ...
Faris Jirjis   +6 more
wiley   +1 more source

Data_Sheet_1_Treatment of atopic dermatitis with upadacitinib: adcare single center experience.pdf

open access: yes
IntroductionThe role of upadacitinib in the management of moderate to severe atopic dermatitis seems promising, but more data on its efficacy and safety are needed.
Daria S. Fomina (9213848)   +11 more
core   +1 more source

Impact of Dupilumab and Upadacitinib Treatment on Epigenetic and Transcriptomic Alterations in Skin‐Homing T Cells of Atopic Dermatitis Patients

open access: yes
Clinical &Experimental Allergy, EarlyView.
Ahmed M. I. Elfiky   +7 more
wiley   +1 more source

Establishing Stakeholder Priorities for Development of a Multi‐Arm Multi‐Stage Platform Trial in Crohn's Disease

open access: yesJCC Plus, Volume 1, Issue 6, November 2026.
An international modified Delphi study identified stakeholder consensus on population, interventions, comparators and outcomes to inform development of a future multi‐arm, multi‐stage adaptive platform trial for Crohn's disease. ABSTRACT Background and Aims The expanding range of advanced therapies for Crohn's disease (CD) has increased complexity in ...
Shellie J. Radford   +15 more
wiley   +1 more source

Clinical Decision‐Making During Monitoring Episodes in Advanced Therapy Management for Inflammatory Bowel Disease: A National Nurse‐Led Service Evaluation

open access: yesJCC Plus, Volume 1, Issue 6, November 2026.
This national, multisite, nurse‐led evaluation highlights practice patterns across UK IBD centres, revealing reliance on reactive flare‐driven treatment modification. Balancing this with structured proactive surveillance and therapeutic drug monitoring aligns with treat‐to‐target principles and supports safer advanced therapy care across diverse ...
Vida Cairnes   +18 more
wiley   +1 more source

One-Year Comparative Effectiveness of Upadacitinib vs Tofacitinib for Ulcerative Colitis: A Multicenter Cohort Study [PDF]

open access: yes
INTRODUCTION: The comparative effectiveness of upadacitinib and tofacitinib for ulcerative colitis (UC) is poorly understood. METHODS: In this retrospective cohort study, we compared steroid-free clinical remission (SFCR) and endoscopic response ...
Allegretti, Jessica R.   +4 more
core   +1 more source

Pruritus Is Frequent and Persistent and Impacts Quality of Life Among Patients With Primary Sclerosing Cholangitis

open access: yesAlimentary Pharmacology &Therapeutics, Volume 64, Issue 9, Page 1288-1297, November 2026.
Among 200 patients with primary sclerosing cholangitis, 38% reported moderate to severe pruritus in the past 6 months. During 6 months of follow up, pruritus severity fluctuated significantly. Pruritus severity was linked to worse colitis activity and lower quality of life.
Richard Dean   +16 more
wiley   +1 more source

Capsulectomy at Explant: Rethinking Spinal Cord Stimulator Infected Generator Pocket Management in the Immunocompromised—A Case Series

open access: yesPain Practice, Volume 26, Issue 8, November 2026.
ABSTRACT Background Surgical site infections (SSI) associated with spinal cord stimulation (SCS) implants pose risks of morbidity, mortality, and increased healthcare costs. Immunocompromised patients are especially vulnerable due to impaired immune responses, delaying diagnosis and increasing complications.
Tigran Kesayan   +4 more
wiley   +1 more source

Practical Use of Upadacitinib in Patients with Severe Atopic Dermatitis in a Real-World Setting: A Systematic Review

open access: yes
Luciano Ibba,1,2 Luigi Gargiulo,1,2 Carlo Alberto Vignoli,1,2 Giovanni Fiorillo,1,2 Mario Valenti,1,2 Antonio Costanzo,1,2 Alessandra Narcisi1 1Dermatology Unit, IRCCS Humanitas Research Hospital, Milan, Italy; 2Department of Biomedical Sciences ...
Ibba L   +6 more
core  

Treatment with Upadacitinib in Difficult-to-Treat (D2T) Psoriatic Arthritis (PsA): A National Multicenter Study of the First 134 Patients in Clinical Practice

open access: yes
Upadacitinib has demonstrated efficacy in psoriatic arthritis in clinical trials, but its real-world performance in difficult-to-treat PsA remains underexplored.
Rosario Garcia-Vicuña   +21 more
core   +1 more source

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