Results 41 to 50 of about 56,471 (243)

A Cre‐dependent lentiviral vector for neuron subtype‐specific expression of large proteins

FEBS Letters, EarlyView.
We designed a versatile and modular lentivector comprising a Cre‐dependent switch and self‐cleaving 2A peptide and tested it for co‐expression of GFP and a 2.8 kb gene of interest (GOI) in mouse cortical parvalbumin (PV+) interneurons and midbrain dopamine (TH+) neurons.
Weixuan Xue, Sandrine Picaud, Régine Hepp, Stéphanie Pons, Uwe Maskos, Bertrand Lambolez, Ludovic Tricoire   +6 more
wiley   +1 more source

Young's integral inequality with upper and lower bounds

Electronic Journal of Differential Equations, 2011
Young's integral inequality is reformulated with upper and lower bounds for the remainder. The new inequalities improve Young's integral inequality on all time scales, such that the case where equality holds becomes particularly transparent in this ...
Douglas R. Anderson, Steven Noren, Brent Perreault   +2 more
doaj  

Optimal consumption and portfolio selection with lower and upper bounds on consumption

Advances in Difference Equations, 2020
We investigate the optimal consumption and investment problem with lower and upper bounds on consumption constraints. We derive closed-form solutions by means of the dynamic programming approach.
Kum-Hwan Roh, Yong Hyun Shin
doaj   +1 more source

Comparing self‐reported race and genetic ancestry for identifying potential differentially methylated sites in endometrial cancer: insights from African ancestry proportions using machine learning models

Molecular Oncology, EarlyView.
Integrating ancestry, differential methylation analysis, and machine learning, we identified robust epigenetic signature genes (ESGs) and Core‐ESGs in Black and White women with endometrial cancer. Core‐ESGs (namely APOBEC1 and PLEKHG5) methylation levels were significantly associated with survival, with tumors from high African ancestry (THA) showing ...
Huma Asif, J. Julie Kim
wiley   +1 more source

MicroRNA 196a contributes to the aggressiveness of esophageal adenocarcinoma through the MYC/TERT/NFκB axis

Molecular Oncology, EarlyView.
mir‐196a promotes Esophagus Adenocarcinoma aggressiveness. On one hand, mir‐196a targets the valosin‐containing protein (VCP) mRNA, causing the accumulation of c‐MYC protein that leads to high amounts of TERT. On the other hand, mir‐196a targets the inhibitor of NFκB (NFKBIA).
Jesús García‐Castillo, Carlos M. Martínez‐Cáceres, Manuel Bernabé‐García, Vicente Munitiz, David Ruiz de Angulo, Pascual Parrilla, Ángeles Ortiz, Luisa F. Martínez de Haro, María L. Cayuela   +8 more
wiley   +1 more source

Dose‐dependent induction of epithelial‐mesenchymal transition in 3D melanoma models by non‐thermal plasma treatment

Molecular Oncology, EarlyView.
Non‐thermal plasma treatment of melanoma cells induced epithelial‐mesenchymal transition (EMT) in a dose‐dependent fashion. This report highlights the critical need to further investigate potential adverse effects of non‐thermal plasma for cancer therapy and to optimize treatment parameters for clinical translation. Despite the promising results of non‐
Eline Biscop, Edgar Cardenas De La Hoz, Hanne Verswyvel, Joey De Backer, Ho Wa Lau, Angela Privat‐Maldonado, Wim Vanden Berghe, Steve Vanlanduit, Evelien Smits, Annemie Bogaerts, Abraham Lin   +10 more
wiley   +1 more source

Independence number in graphs and its upper bounds [PDF]

Journal of Mahani Mathematical Research
‎In this paper, we use the double counting method to find some upper bounds for the independence number of a simple graph in terms of its order, size and  maximum degree.   Moreover,  we determine extremal graphs attaining equality in upper bounds.
Farzad Shaveisi
doaj   +1 more source

ITGAV and SMAD4 influence the progression and clinical outcome of pancreatic ductal adenocarcinoma

Molecular Oncology, EarlyView.
In SMAD4‐positive pancreatic ductal adenocarcinoma (PDAC), integrin subunit alpha V (ITGAV) activates latent TGF‐β, which binds to the TGF‐β receptor and phosphorylates SMAD2/3. The activated SMAD2/3 forms a complex with SMAD4, and together they translocate to the nucleus, modulating gene expression to promote proliferation, migration, and invasion. In
Daniel K. C. Lee, Keyue Chen, Ryan Loke, Xiang Li, David Liubart, Golam T. Saffi, Jonathan T. S. Chow, Ché M. P. Melo, Lydia To, Leonardo Salmena   +9 more
wiley   +1 more source

Upper and lower bounds of integral operator defined by the fractional hypergeometric function

Open Mathematics, 2015
In this article, we impose some studies with applications for generalized integral operators for normalized holomorphic functions. By using the further extension of the extended Gauss hypergeometric functions, new subclasses of analytic functions ...
Ibrahim Rabha W., Ahmad Muhammad Zaini, Al-Janaby Hiba F.   +2 more
doaj   +1 more source

Bounds for the Z-eigenpair of general nonnegative tensors

Open Mathematics, 2016
In this paper, we consider the Z-eigenpair of a tensor. A lower bound and an upper bound for the Z-spectral radius of a weakly symmetric nonnegative irreducible tensor are presented.
Liu Qilong, Li Yaotang
doaj   +1 more source