Results 61 to 70 of about 156,468 (326)

Sharp upper and lower bounds on the length of general Davenport-Schinzel sequences

Journal of Combinatorial Theory, 1989
We obtain sharp upper and lower bounds on the maximal length I,(n) of (n, s)Davenport-Schinzel sequences, i.e., sequences composed of n symbols, having no two adjacent equal elements and containing no alternating subsequence of length s + 2. We show that
P. Agarwal, M. Sharir, P. Shor
semanticscholar   +1 more source

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

Molecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska, Stephany Gallardo, Nur S. Zainal, Leena Arora, Matthew Ellis, Maria‐Antoinette Lopez, Judith Austine, Sai Pittla, Serena J Chee, Aiman Alzetani, Emily C Shaw, Christian H Ottensmeier, Gareth J Thomas, Christopher J Hanley   +13 more
wiley   +1 more source

Exploring new upper and lower bounds for the $A_{\alpha}$-energy of graphs [PDF]

Categories and General Algebraic Structures with Applications
Let $G$ be a graph on $n$ vertices and $m$ edges. For $\alpha \in [0,1]$, the $A_{\alpha}$-matrix of $G$ is defined as $A_{\alpha}(G) = \alpha D(G) + (1- \alpha) A(G)$, where $A(G)$ is the adjacency matrix and $D(G)$ is the degree diagonal matrix of $G$.
Mainak Basunia, Pratima Panigrahi
doaj   +1 more source

Tight bounds for the median of a gamma distribution.

PLoS ONE, 2023
The median of a standard gamma distribution, as a function of its shape parameter k, has no known representation in terms of elementary functions. In this work we prove the tightest upper and lower bounds of the form 2-1/k(A + k): an upper bound with A =
Richard F Lyon
doaj   +1 more source

Estimating Upper and Lower Bounds on the Performance of Word-Sense Disambiguation Programs

Annual Meeting of the Association for Computational Linguistics, 1992
We have recently reported on two new word-sense disambiguation systems, one trained on bilingual material (the Canadian Hansards) and the other trained on monolingual material (Roget's Thesaurus and Grolier's Encyclopedia).
W. Gale, Kenneth Ward Church, David Yarowsky   +2 more
semanticscholar   +1 more source

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola, Yasmine Illi, Anna Bircher, Marijn Wilmink, Rachele F. Malagutti, Solenn Ottié, Cordelia Schuler, Pedro A. Ruiz, Cheryl de Vallière, Klaus Seuwen, Gerhard Rogler, Martin Hausmann   +11 more
wiley   +1 more source

Spatial and single‐nuclei transcriptomics reveals idiosyncratic and generic patterns in papillary and anaplastic thyroid cancers

Molecular Oncology, EarlyView.
Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur, Joel Rodrigues Vitória, Manuel Saiselet, Ligia Craciun, Denis Larsimont, Anne Lefort, Frédérick Libert, Carine Maenhaut, Sabine Costagliola, Maxime Tarabichi, Mirian Romitti, Vincent Detours   +11 more
wiley   +1 more source

An Upper Bound on the Error Induced by Saddlepoint Approximations—Applications to Information Theory

Entropy, 2020
This paper introduces an upper bound on the absolute difference between: ( a ) the cumulative distribution function (CDF) of the sum of a finite number of independent and identically distributed random variables with finite absolute third moment;
Dadja Anade, Jean-Marie Gorce, Philippe Mary, Samir M. Perlaza   +3 more
doaj   +1 more source

Upper and lower bounds for competitive group testing

Discrete Applied Mathematics, 2023
We consider competitive algorithms for adaptive group testing problems. In the first part of the paper, we develop an algorithm with competitive constant c < 1.452 thus improving the up to now best known algorithms with constants 1.5+epsilon from 2003.
Robert Scheidweiler, Eberhard Triesch
openaire   +4 more sources

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source