Results 41 to 50 of about 60,982 (263)

An unexpected alternative viologen electron mediator site in tungsten‐containing formate dehydrogenase

open access: yesFEBS Letters, EarlyView.
An unexpected alternative interaction site for ethyl viologen was identified in formate dehydrogenase 1 from Methylorubrum extorquens. Combined mutagenesis, kinetic analysis, and docking revealed that aromatic residues near an iron–sulfur cluster enable flavin mononucleotide‐independent electron transfer, offering a framework for engineering improved ...
Eleni G. Poloniataki, Yong Hwan Kim
wiley   +1 more source

NEW UPPER AND LOWER BOUNDS LINE OF SIGHT PATH LOSS MODELS FOR MOBILE PROPAGATION IN BUILDINGS

open access: yesASEAN Journal on Science and Technology for Development, 2017
This paper proposes a method to predict line-of-sight (LOS) path loss in buildings. We performed measurements in two different type of buildings at a frequency of 1.8 GHz and propose new upper and lower bounds path loss models which depend on max and min
Supachai Phaiboon   +2 more
doaj   +1 more source

Cell geometry and membrane protein crowding constrain Escherichia coli growth rate, overflow metabolism, respiration, and maintenance energy

open access: yesFEBS Letters, EarlyView.
The physical dimensions and shape of bacterial cells define the surface area available to acquire nutrients and the volume available for synthesizing proteins and DNA. Here, we use computational systems biology to decode the importance of cell geometry as a major determinant of prokaryotic phenotype, including growth rate and metabolic efficiency. This
Ross P. Carlson   +6 more
wiley   +1 more source

Optimal consumption and portfolio selection with lower and upper bounds on consumption

open access: yesAdvances in Difference Equations, 2020
We investigate the optimal consumption and investment problem with lower and upper bounds on consumption constraints. We derive closed-form solutions by means of the dynamic programming approach.
Kum-Hwan Roh, Yong Hyun Shin
doaj   +1 more source

ABL kinase‐dependent phosphorylation of SH proteins promotes their direct interaction with CRK family SH2 domains

open access: yesFEBS Letters, EarlyView.
CT10 regulator of kinase (CRK) and CRK‐Like (CRKL) are signaling adaptors driving cell adhesion, motility, differentiation, and proliferation. SH2‐domain containing (SH) proteins are enriched in YXXP motifs which when phosphorylated create preferred binding sites for CRK family SH2 domains.
Phoebe M. Cousens   +8 more
wiley   +1 more source

A new sequence related to the Euler–Mascheroni constant

open access: yesJournal of Inequalities and Applications, 2018
In this paper, we provide a new quicker sequence convergent to the Euler–Mascheroni constant using an approximation of Padé type. Our sequence has a relatively simple form and higher speed of convergence.
Shanhe Wu, Gabriel Bercu
doaj   +1 more source

Tight bounds for the median of a gamma distribution.

open access: yesPLoS ONE, 2023
The median of a standard gamma distribution, as a function of its shape parameter k, has no known representation in terms of elementary functions. In this work we prove the tightest upper and lower bounds of the form 2-1/k(A + k): an upper bound with A =
Richard F Lyon
doaj   +1 more source

The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers

open access: yesMolecular Oncology, EarlyView.
The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce   +11 more
wiley   +1 more source

On the Achievable Stabilization Delay Margin for Linear Plants with Time-Varying Delays

open access: yesMathematics, 2017
The paper contributes to stabilization problems of linear systems subject to time-varying delays. Drawing upon small gain criteria and robust analysis techniques, upper and lower bounds on the largest allowable time-varying delay are developed by using ...
Jing Zhu
doaj   +1 more source

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

open access: yesMolecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang   +12 more
wiley   +1 more source

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