Results 61 to 70 of about 861,443 (311)

Polarization‐resolved femtosecond Vis/IR spectroscopy tailored for resolving weak signals in biological samples using minimal sample volume

FEBS Open Bio, EarlyView.
Unique biological samples, such as site‐specific mutant proteins, are available only in limited quantities. Here, we present a polarization‐resolved transient infrared spectroscopy setup with referencing to improve signal‐to‐noise tailored towards tracing small signals. We provide an overview of characterizing the excitation conditions for polarization‐
Clark Zahn, Karsten Heyne
wiley   +1 more source

Bleeding outcomes and factor utilization after switching to an extended half-life product for prophylaxis in haemophilia A in Austria

Scientific Reports, 2021
To prevent bleeding in severe haemophilia A [SHA, defined as factor VIII (FVIII) activity 
Cihan Ay, Clemens Feistritzer, Joachim Rettl, Gerhard Schuster, Anna Vavrovsky, Leonard Perschy, Ingrid Pabinger   +6 more
doaj   +1 more source

Upper bounds on asymmetric dark matter self annihilation cross sections [PDF]

Journal of Cosmology and Astroparticle Physics, 2012
13 pages, 3 Figures, Reference added, improved ...
Ellwanger, Ulrich, Mitropoulos, Pantelis
openaire   +3 more sources

Dihydroorotate dehydrogenase (DHODH) regulates trophoblast syncytialization through organelle stress–induced cellular senescence

FEBS Open Bio, EarlyView.
The inhibition of mitochondrial dihydroorotate dehydrogenase (DHODH) impairs syncytialization and induces cellular senescence via mitochondrial and endoplasmic reticulum stress in human trophoblast stem cells, elevating sFlt1/PlGF levels, a hallmark of placental dysfunction in hypertensive disorders of pregnancy.
Kanoko Yoshida, Kazuya Kusama, Ayaka Horiuchi, Yu Kawaguchi, Atsuya Tsuru, Mikihiro Yoshie, Kazuhiro Tamura   +6 more
wiley   +1 more source

Online supervised versus workplace corrective exercises for upper crossed syndrome: a protocol for a randomized controlled trial [PDF]

, 2021
Zohreh Yaghoubitajani, Mehdi Gheitasi, Mohammad Bayattork, Lars L. Andersen   +3 more
openalex   +1 more source

Development of human monoclonal antibodies against TARM1 by yeast display

FEBS Open Bio, EarlyView.
Human monoclonal antibodies against TARM1 are generated by yeast display‐guided selection. These antibodies bind to soluble and cell‐surface forms of TARM1. Also, these antibodies exhibit agonistic activity in the NFAT‐GFP reporter assay, indicating that TARM1 signaling can be functionally modulated by antibodies and suggesting TARM1 as a potential ...
Rikio Yabe, Mayumi Saeki, Masaaki Hashiguchi, Sayaka Ono, Kazuhisa Aoki, Hidetaka Tanno   +5 more
wiley   +1 more source

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

FEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane, Lea Nikolić, Lorenzo Maraio, Thomas Goiran, Nathan Karpilovsky, Stefano Sellitto, Vangelis Bouris, Jiang‐An Yin, Ronald Melki, Edward A Fon, Adriano Aguzzi, Elena De Cecco   +11 more
wiley   +1 more source

Efficacy and safety of taxane plus ramucirumab for advanced gastric cancer after chemotherapy plus nivolumab

Scientific Reports
Background and purpose Taxane plus ramucirumab (RAM) is the standard second-line treatment for advanced gastric cancer (AGC). However, data on second-line therapy following first-line treatment with nivolumab remains limited. This study aimed to evaluate
Toshihiko Matsumoto, Tatsuki Ikoma, Chinatsu Makiyama, Tomoyo Yasuda, Shogen Boku, Akio Nakasya, Nobuhiro Shibata, Hiroki Nagai, Takao Tsuduki, Yusuke Matsumoto, Hisateru Yasui, Reiji Higashi, Akitoshi Sasamoto, Hironaga Satake, Kentaro Inoue, Masashi Kanai, Makoto Yamasaki   +16 more
doaj   +1 more source

Correlation between upper airway morphological changes and jaw movement after bimaxillary orthognathic surgery in patients with skeletal Class Ⅲ malocclusion [PDF]

Kouqiang yixue
Objective To investigate the morphological changes in the upper airway after bimaxillary surgery in patients with skeletal Class Ⅲ malocclusion and the relationship between jaw movement and airway changes using CBCT.
LI Gen, GUO Songsong, CAI Guanhui, SUN Lian, SUN Wen, WANG Hua
doaj   +1 more source

Suppression of lung adenocarcinoma migration through organelle alkalization by human lactoferrin – albumin fusion

FEBS Open Bio, EarlyView.
This paper reveals how human lactoferrin–albumin fusion (hLF‐HSA) potently suppresses lung adenocarcinoma cell migration. hLF‐HSA upregulates NHE7, leading to Golgi alkalization, disruption of the Golgi secretome, downregulation of MMP1, and reversal of EMT. These findings suggest a novel Golgi‐targeting strategy to suppress cancer cell migration.
Hana Nopia, Masahiro Kimura, Daisuke Kurimoto, Atsushi Sato   +3 more
wiley   +1 more source