Results 11 to 20 of about 159,640 (258)

Targeting CLDN18.2 in cancers of the gastrointestinal tract: New drugs and new indications

Frontiers in Oncology, 2023
Cancers of the gastrointestinal (GI) tract greatly contribute to the global cancer burden and cancer-related death. Claudin-18.2(CLDN18.2), a transmembrane protein, is a major component of tight junctions and plays an important role in the maintenance of
Jinxia Chen, Zhiyuan Xu, Zhiyuan Xu, Zhiyuan Xu, Can Hu, Can Hu, Can Hu, Shengjie Zhang, Shengjie Zhang, Shengjie Zhang, Mengli Zi, Li Yuan, Li Yuan, Li Yuan, Xiangdong Cheng, Xiangdong Cheng, Xiangdong Cheng   +16 more
doaj   +1 more source

Protein degradation technology: a strategic paradigm shift in drug discovery

Journal of Hematology & Oncology, 2021
Targeting pathogenic proteins with small-molecule inhibitors (SMIs) has become a widely used strategy for treating malignant tumors. However, most intracellular proteins have been proven to be undruggable due to a lack of active sites, leading to a ...
Haobin Li, Jinyun Dong, Maohua Cai, Zhiyuan Xu, Xiang-Dong Cheng, Jiang-Jiang Qin   +5 more
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The role of macrophages in gastric cancer

Frontiers in Immunology, 2023
As one of the deadliest cancers of the gastrointestinal tract, there has been limited improvement in long-term survival rates for gastric cancer (GC) in recent decades.
Jiaqing Zhang, Jiaqing Zhang, Can Hu, Can Hu, Can Hu, Ruolan Zhang, Ruolan Zhang, Jingli Xu, Jingli Xu, Yanqiang Zhang, Yanqiang Zhang, Yanqiang Zhang, Li Yuan, Li Yuan, Li Yuan, Shengjie Zhang, Shengjie Zhang, Shengjie Zhang, Siwei Pan, Siwei Pan, Siwei Pan, Mengxuan Cao, Mengxuan Cao, Mengxuan Cao, Jiangjiang Qin, Jiangjiang Qin, Jiangjiang Qin, Xiangdong Cheng, Xiangdong Cheng, Xiangdong Cheng, Zhiyuan Xu, Zhiyuan Xu, Zhiyuan Xu   +32 more
doaj   +1 more source

Clinical and genomic characterization of pancreatic ductal adenocarcinoma patients with lung oligometastasis

ESMO Gastrointestinal Oncology, 2023
Background: Lung-only relapse following resection of pancreatic ductal adenocarcinoma (PDAC) is rare. While oligometastatic lung disease (OMLD) is detected after PDAC resection, its clinical and molecular features remain unclear.
N.S. Tissera, M. Chiaravalli, A. Turpin, R. Luca, F. Castet, C. Fabregat-Franco, G. Castillo, D. López-Valbuena, G. Tortora, P. Hammel, J.M. O’Connor, J. Matito, A. Vivancos, T.V. Tian, T. Macarulla   +14 more
doaj   +1 more source

Chebulagic acid suppresses gastric cancer by inhibiting the AURKA/β-catenin/Wnt pathway

Frontiers in Pharmacology, 2023
Gastric cancer (GC) is a prevalent malignant neoplasm that poses a serious threat to human health. Overexpression of Aurora A (AURKA) is frequently associated with the self-renewal and tumorigenicity of various cancers.
Jing Zhao, Jing Zhao, Jing Zhao, Jing Zhao, Yunfu Shi, Yunfu Shi, Yubo Ma, Yubo Ma, Yubo Ma, Yubo Ma, Libin Pan, Libin Pan, Libin Pan, Libin Pan, Yanan Wang, Yanan Wang, Yanan Wang, Yanan Wang, Li Yuan, Li Yuan, Li Yuan, Li Yuan, Jinyun Dong, Jieer Ying, Jieer Ying   +24 more
doaj   +1 more source

Ultra-magnifying narrow-band imaging for endoscopic diagnosis of gastric intestinal metaplasia: a pilot image analysis study

Endoscopy International Open, 2021
Background and study aims Narrow-band imaging (NBI) with or without magnification has recently been used for diagnosis of gastric intestinal metaplasia (GIM).
Hiroyoshi Iwagami, Noriya Uedo, Hon-Chi Yip, Satoki Shichijo, Takashi Kanesaka, Akira Maekawa, Sachiko Yamamoto, Koji Higashino, Yoji Takeuchi, Ryu Ishihara, Shin-ichi Nakatsuka   +10 more
doaj   +1 more source

Imaging biomarkers in upper gastrointestinal cancers

BJR|Open, 2019
In parallel with the increasingly widespread availability of high performance imaging platforms and recent progresses in pathobiological characterisation and treatment of gastrointestinal malignancies, imaging biomarkers have become a major research topic due to their potential to provide additional quantitative information to conventional imaging ...
Gabelloni, Michela, Faggioni, Lorenzo, Neri, Emanuele   +2 more
openaire   +3 more sources

Prognostic prediction by a novel integrative inflammatory and nutritional score based on least absolute shrinkage and selection operator in esophageal squamous cell carcinoma

Frontiers in Nutrition, 2022
BackgroundThis study aimed to establish and validate a novel predictive model named integrative inflammatory and nutritional score (IINS) for prognostic prediction in esophageal squamous cell carcinoma (ESCC).Materials and methodsWe retrospectively ...
Jifeng Feng, Jifeng Feng, Jifeng Feng, Liang Wang, Xun Yang, Qixun Chen, Xiangdong Cheng   +6 more
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Development and validation of pretreatment nomogram for disease‐specific mortality in gastric cancer‐A competing risk analysis

Cancer Medicine, 2021
Background In several reports, gastric cancer nomograms for predicting overall or disease‐specific survival have been described. The American Joint Committee on Cancer (AJCC) introduced the attractiveness of disease‐specific mortality (DSM) as an ...
Etsuro Bando, Xinge Ji, Michael W. Kattan, Maria Bencivenga, Giovanni deManzoni, Masanori Terashima   +5 more
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Macrophage spatial heterogeneity in gastric cancer defined by multiplex immunohistochemistry

Nature Communications, 2019
Tumor associated macrophages are functionally and phenotypically heterogeneous. Here the authors describe the spatial distribution of distinct macrophage populations within regions of gastric cancer and probe their associations with clinical outcomes ...
Yu-Kuan Huang, Minyu Wang, Yu Sun, Natasha Di Costanzo, Catherine Mitchell, Adrian Achuthan, John A. Hamilton, Rita A. Busuttil, Alex Boussioutas   +8 more
doaj   +1 more source