Results 111 to 120 of about 3,463,486 (343)

Development of human monoclonal antibodies against TARM1 by yeast display

FEBS Open Bio, EarlyView.
Human monoclonal antibodies against TARM1 are generated by yeast display‐guided selection. These antibodies bind to soluble and cell‐surface forms of TARM1. Also, these antibodies exhibit agonistic activity in the NFAT‐GFP reporter assay, indicating that TARM1 signaling can be functionally modulated by antibodies and suggesting TARM1 as a potential ...
Rikio Yabe, Mayumi Saeki, Masaaki Hashiguchi, Sayaka Ono, Kazuhisa Aoki, Hidetaka Tanno   +5 more
wiley   +1 more source

Diagnostic uncertainty of clinical T2 disease and its impact on treatment stratification in upper tract urothelial carcinoma: a multicenter retrospective study

Scientific Reports
Accurate clinical staging of upper tract urothelial carcinoma (UTUC) remains challenging, and discrepancies between clinical and pathological T stages may result in missed opportunities for appropriate treatment.
Masanobu Shiga, Shuya Kandori, Shingo Hatakeyama, Naoki Fujita, Mizuki Kobayashi, Daiki Ikarashi, Hiroki Fukuhara, Takuma Sato, Shingo Myoen, Motohide Uemura, Takamitsu Inoue, Masaaki Oikawa, Yasuhiro Kaiho, Jun Miyazaki, Yoshiyuki Kojima, Hisanobu Adachi, Akihiro Ito, Norihiko Tsuchiya, Wataru Obara, Tomonori Habuchi, Chikara Ohyama, Hiroyuki Nishiyama   +21 more
doaj   +1 more source

Radical Politics of Rich People: British Upper Class Support of Interwar Communism and Fascism

, 2014
This thesis examines why members of the British aristocracy and upper class supported communism and fascism during the interwar period. The pre-1900 generation attempted to hold onto their pre-war status and power by supporting fascism and its tenets of ...
Yadlin, Michal Rebecca
core  

Establishing an assay to evaluate d‐amino acid oxidase enzyme kinetics and inhibition using WST‐8 redox dye

FEBS Open Bio, EarlyView.
This study investigated a novel WST‐8‐based assay for evaluating d‐Amino acid oxidase (DAO) inhibitors. We confirmed its effectiveness using known inhibitors and found that uremic toxins possess relatively weak inhibitory activity compared to existing drugs.
Kahoko Miyake, Yuki Enoki, Yuka Nakazawa, Kazuaki Taguchi, Kazuaki Matsumoto   +4 more
wiley   +1 more source

Stenting Prior to Cystectomy is an Independent Risk Factor for Upper Urinary Tract Recurrence.

, 2017
PURPOSE Patients with bladder cancer who present with hydronephrosis may require drainage of the affected kidney before receiving further cancer treatment. Drainage can be done by retrograde stenting or percutaneously.
Bernhard Kiss, Wüthrich, Patrick Yves, Roth, Beat, Furrer, M.A., Kiss, Bernhard, Patrick Y. Wuethrich, Fiona C. Burkhard, Roth, B., George N. Thalmann, Beat Roth, Thalmann, G.N., Burkhard, F.C., Kiss, B., Furrer, Marc, Wuethrich, P.Y., Marc A. Furrer, Burkhard, Fiona C., Thalmann, George   +17 more
core   +1 more source

Evolutionarily divergent DUF4465 domains have a common vitamin B12‐binding function

FEBS Open Bio, EarlyView.
We show that DUF4465 family proteins, widespread across bacteria from gut microbiomes, hydrothermal vents, and soil, share a common vitamin B12‐binding function. These augmented β‐jellyroll proteins bind vitamin B12 via extended loops. Our findings establish sequence‐diverse DUF4465 proteins as a widespread class of B12‐binding proteins, highlighting ...
Charlea Clarke, Michal Banasik, Rokas Juodeikis, Martin J. Warren, Richard W. Pickersgill   +4 more
wiley   +1 more source

Cumulative incidence and risk factors for recurrence of upper tract urothelial carcinoma in patients undergoing radical cystectomy

BJUI Compass
Objectives This study aimed to evaluate the cumulative incidence of upper tract urothelial carcinoma (UTUC) recurrence and identify its risk factors in patients who underwent radical cystectomy (RC).
Ryo Yamashita, Masafumi Nakamura, Akifumi Notsu, Koiku Asakura, Kimitsugu Usui, Yuma Sakura, Hideo Shinsaka, Masato Matsuzaki, Takashi Sugino, Ryuichi Mizuno, Masashi Niwakawa, Mototsugu Oya   +11 more
doaj   +1 more source

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

FEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane, Lea Nikolić, Lorenzo Maraio, Thomas Goiran, Nathan Karpilovsky, Stefano Sellitto, Vangelis Bouris, Jiang‐An Yin, Ronald Melki, Edward A Fon, Adriano Aguzzi, Elena De Cecco   +11 more
wiley   +1 more source

Current Status of Robot Assisted Laparoscopic Radical Nephroureterectomy for Management of Upper Tract Urothelial Carcinoma

, 2013
Upper tract urothelial carcinomas (UUT-UC) are usually aggressive tumours and require radical treatments. The standard of care for localised UUT-UC is radical nephroureterectomy (RNU).
신태영, 임세이캣, 나군호
core   +1 more source

Suppression of lung adenocarcinoma migration through organelle alkalization by human lactoferrin – albumin fusion

FEBS Open Bio, EarlyView.
This paper reveals how human lactoferrin–albumin fusion (hLF‐HSA) potently suppresses lung adenocarcinoma cell migration. hLF‐HSA upregulates NHE7, leading to Golgi alkalization, disruption of the Golgi secretome, downregulation of MMP1, and reversal of EMT. These findings suggest a novel Golgi‐targeting strategy to suppress cancer cell migration.
Hana Nopia, Masahiro Kimura, Daisuke Kurimoto, Atsushi Sato   +3 more
wiley   +1 more source