Results 181 to 190 of about 240,373 (307)
Advanced Science, EarlyView.Neuronal PKM2‐driven glycolysis generates excess lactate that triggers histone H3K18 lactylation (H3K18la), establishing a pathogenic metabolic‐epigenetic axis in epilepsy. Elevated H3K18la enriches the Cop1 promoter, transcriptionally upregulating the E3 ubiquitin ligase COP1, which subsequently drives proteasomal degradation of GABAARβ2 and impairs ...
Yuan Meng +8 more
wiley +1 more source
CD4+ Tregs Drive Post‐Ischemic Sprouting Angiogenesis via Endothelial YY1/MAML1 Reactivation
Advanced Science, EarlyView.ABSTRACT Microvascular complications of diabetes are chronic diseases of small vessels. We previously found that CD4+ regulatory T‐cells (Tregs) are markedly reduced in type 2 diabetes (T2D) after ischemic injury in both mice and humans, and that Treg deficiency in immunodeficient mice impairs vascular regeneration.
Hang Qu +10 more
wiley +1 more source
Pedagogic practice and influence in a social science class
, 2011 The teaching and practice of democracy in schools might be considered particularly important in the present era as young people are spending increasing amounts of time in education.
Rosvall, Per-Åke,
core
Advanced Science, EarlyView.OAML harbors recurrent IGLL5 mutations that reinforce CD79A/CD79B‐associated BCR signaling. Mechanistic analysis of the S47G and A54G variants reveals induction of CXCL10/CXCL11, enhanced CD8+ T‐cell recruitment, and exhaustion‐associated dysfunction, supporting an immune‐tolerant niche.
Andi Zhao +12 more
wiley +1 more source
Adult students in upper secondary education in Italy
, 2018 Upper secondary education has been identified by different institutions as the minimum educational threshold in a knowledge society, a necessary requirement for citizens of all ages to respond to the social changes driven by global technological innovation. Figures from the Organization for Economic Cooperation and Development (OECD) unfortunately show
openaire +1 more source
Pedagogic practice and influence in a vehicle programme class
, 2011 The teaching and practice of democracy in schools might be considered particularly important in the present era as young people are spending increasing amounts of time in education.
Rosvall, Per-Åke,
core
G3BP1 Succinylation at K413 is Critical for Cardiac Function by Modulating PI3K‐AKT‐mTOR Signal Axis
Advanced Science, EarlyView.Schematic illustrating the impact of G3BP1 succinylation at K413 on cardiac function. In the healthy human heart, G3BP1 succinylation maintains homeostatic mTOR signaling. In patients with dilated cardiomyopathy (DCM) and heart failure (HF), G3BP1 de‐succinylation induces RagA expression and disrupts the binding of the TSC1/2 complex, leading to the ...
Yuan Zhang +9 more
wiley +1 more source
, 2019 Transnational governance is expanding rapidly. From a political education perspective, an important question is to what extent and how these are included in the political universe that adolescents are being prepared for at school.
Børhaug, Kjetil,
core
A Microbial Lipid‐ATP Synthase Axis Fuels NK Cell Antitumor Activity
Advanced Science, EarlyView.This study focuses on the mechanism by which gut microbiota‐derived outer membrane vesicles (OMVs) regulate NK cell antitumor activity. B. intestinalis is identified to decrease extra‐intestinal tumor growth via its OMVs enriched in sphingosine (SP).
Kaiyuan Yu +16 more
wiley +1 more source