Results 31 to 40 of about 133,560 (262)

Identification of a Shiga toxin A‐derived peptide internalized into Gb3 receptor‐bearing cells via interaction with the Shiga toxin B subunit

FEBS Letters, EarlyView.
The process of internalization of the Shiga toxin A subunit via formation of a complex with the Shiga toxin B subunit, which specifically binds to the Gb3 receptor. The peptide is designed to act as a carrier of drugs into cancer cells. Here, we explored the potential of peptides derived from the catalytic A subunit of Shiga toxin (STxA) to be drug ...
Giulia Opassi, João C. Encarnação, Valeria Napolitano, Grzegorz Dubin, Grzegorz Popowicz, Karl Andersson, U. Helena Danielson   +6 more
wiley   +1 more source

How Sleep-Deprived People See and Evaluate Others’ Faces: An Experimental Study

Nature and Science of Sleep, 2022
Lieve T van Egmond,1,* Elisa MS Meth,1,* Shervin Bukhari,1 Joachim Engström,1 Maria Ilemosoglou,1 Jasmin Annica Keller,1 Shiyang Zhou,1 Helgi B Schiöth,2 Christian Benedict3 1Department of Surgical Sciences (Sleep Science Laboratory), Uppsala ...
van Egmond LT, Meth EMS, Bukhari S, Engström J, Ilemosoglou M, Keller JA, Zhou S, Schiöth HB, Benedict C   +8 more
doaj  

Interaction of HS1BP3 with cortactin modulates TKS5 localisation, cell secretion and cancer malignancy

Molecular Oncology, EarlyView.
Here, we demonstrate that HS1BP3 interacts with Cortactin through a proline‐rich region (PRR3.1) and show that this interaction, and HS1BP3 itself, promote cancer cell proliferation and invasion. Inhibition of this interaction leads to build‐up of TKS5 in multivesicular endosomes and altered secretion of CD63 and CD9, providing an explanation for the ...
Arja Arnesen Løchen, Kristiane Søreng, Chiara Veroni, Laura Trachsel‐Moncho, Nagham Asp, Robin Gaupset, Lars Gustav Lyckander, Helene Knævelsrud, Lars Eftang, Anne Simonsen   +9 more
wiley   +1 more source

Pharmacological inhibition of the PERK pathway modulates hepatocellular carcinoma growth and immune signaling

FEBS Open Bio, EarlyView.
Pharmacological inhibition of PERK in a DEN‐induced mouse model of liver cancer does not reduce tumor burden but alters cellular stress signaling. Despite blocking PERK activity, downstream stress responses, including CHOP expression, remain active, suggesting compensatory mechanisms within the unfolded protein response that may influence tumor ...
Ada Lerma‐Clavero, Maria Kopsida, Nathalie Arendt, Hans Lennernäs, Markus Sjöblom, Femke Heindryckx   +5 more
wiley   +1 more source

Dimethyl Fumarate, But Not Rituximab, Reduces Serum GFAP Levels and PIRMA in Relapsing–Remitting MS

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Serum neurofilament light chain (sNfL) and glial fibrillary acidic protein (sGFAP) levels are believed to reflect mainly acute and chronic disease processes in multiple sclerosis (MS), respectively. In this study, we investigated whether dimethyl fumarate (DMF) and rituximab (RTX) differentially affect these biomarkers.
F. Shawket, J. Lycke, J. Salzer, F. Piehl, K. Fink, N. Lange, J. Mellergård, C. Malmeström, P. Sundström, I. Erngren, A. al‐Grety, E. Freyhult, K. Kultima, J. Burman, A. Svenningsson   +14 more
wiley   +1 more source

Real-time air pollution monitoring with sensors on city bus

Digital Communications and Networks, 2020
This paper presents an experimental study on real-time air pollution monitoring using wireless sensors on public transport vehicles. The study is part of the GreenIoT project in Sweden, which utilizes Internet-of-Things to measure air pollution level in ...
Sami Kaivonen, Edith C.-H. Ngai
doaj   +1 more source

An In Situ Oxidation Strategy for Ti3C2@TiO2 Heterojunction: Narrow‐Band Photodetection and Trace Chromium Ion Determination

Advanced Functional Materials, EarlyView.
A Ti3C2@TiO2 heterostructure has been successfully fabricated by an in situ oxidation approach. The as‐fabricated Ti3C2@TiO2‐based photodetector exhibits narrow‐spectrum response with excellent stability. It also realizes sensitive Cr(VI) detection in a large concentration range of 10−12–10−6 M with an ultra‐low detection limit of 7.6 × 10−12 M ...
Jiahui Hou, Jiale Ai, Mingqi He, Yang Wu, Lingniu Yang, Yingjie Yuan, Xuanhao Lao, Artem V. Kuklin, Liang Chen, Hans Ågren, Lingfeng Gao, Youju Huang   +11 more
wiley   +1 more source

NET‐DNA Activates the ANXA2/TMEM215/BiP Axis to Promote Mitophagy‐Mediated Anoikis Resistance in Endometriosis

Advanced Science, EarlyView.
NET‐DNA is enriched during early endometriotic lesion establishment and drives anoikis resistance by promoting an ANXA2–TMEM215–BiP axis. This pathway strengthens ER–mitochondria contacts, enhances PINK1/Parkin‐associated mitophagy, preserves mitochondrial homeostasis, and supports ectopic stromal cell survival, thereby facilitating lesion persistence ...
Honglin Wang, Yanling Gou, Huiyan Zhang, Hongli Wang, Beidi Wang, Jinming Liu, Yingying Cao, Ruru Bai, Yuxin Zhao, Xu Han, Chao Feng, Xin Huang, Zongfeng Zhang   +12 more
wiley   +1 more source

Recensioner

Tidskrift för Litteraturvetenskap, 2019
PETER DEGERMAN TALA FÖR DET GRÖNA I LÖVET: Ekopoesi som estetik och aktivism Lund: Ellerströms, 2018, 309 s. INGRID LINDELL & ANDERS ÖHMAN (RED.) FÖR BERÄTTELSENS SKULL: Modeller för litteraturundervisningen Stockholm: Natur och Kultur, 2019, 215 s.
Gustav Borsgård, Arne Florin, Martin Malmström, Sofia Roberg, Anders E. Johansson, Ylva Lindberg, Jesper Olsson   +6 more
doaj   +1 more source

Comment on the ‘Uppsala critique’

Energy Policy, 2014
AbstractThis paper discusses the criticisms of the IEA World Energy Outlook raised by Aleklett et al. (2010), often referred to as the ‘Uppsala critique’. The major argument of Aleklett et al. is that the rates of depletion, the ratio of annual production to remaining resources or reserves, assumed by the IEA in certain categories of fields are ...
openaire   +2 more sources