Results 51 to 60 of about 606,045 (292)

Thermal Shifts Dominate Single‐Gene Responses to Transcription‐Targeting Antibiotics

Advanced Science, EarlyView.
Thermal shifts reshape bacterial responses to transcription‐targeting antibiotics. In E. coli, temperature can dominate antibiotic‐induced genome‐wide expression, particularly outside 30°C–39°C, through changes in adenosine triphosphate (ATP), nucleoid organization, and drug‐target engagement.
Rahul Jagadeesan, Amir M. Arsh, Vatsala Chauhan, Suchintak Dash, Pooja Ravaria, Andre S. Ribeiro   +5 more
wiley   +1 more source

Uppsala Health Summit Pre-conference Report 2023 : Chemical Pollution and One Health, From Reactivity to Proactivity

, 2023
CONTENTS Chemical Pollution and One Health - p.4WorkshopsA - Towards an Intergovernmental Panel on Chemical Pollution - p.8B - Testing Our Way to a Safe Environment - p.12C - The Health and Environmental Challenges of Recycling Chemicals in the ...

core   +1 more source

AI‐Designed TREM1‐Targeted LYTAC Nanoparticles Reprogram the Neuroimmune Microenvironment in Traumatic Brain Injury

Advanced Science, EarlyView.
AI‐enabled de novo design of a TREM1 binder, integrated into a BBB‐crossing and macrophage‐targeted nanoplatform, enables TREM1 degradation and attenuates neuroinflammation, thereby promoting neuroprotection and tissue repair after traumatic brain injury. ABSTRACT Secondary neuroinflammation drives progressive damage after traumatic brain injury (TBI),
Yimin Huang, Yuan Liu, Huan Peng, Yu Ni, Zhengqiao Jiang, Chenxuan Yu, Xincheng Zhang, Huayu Kang, Yanchao Liu, Juan Chen, Kai Zhao, Lin Han, Xin Zou, Kai Shu, Xiaochuan Wang, Jian‐Zhi Wang, Ting Lei, Chao Gan, Jianfeng Liu, Huaqiu Zhang   +19 more
wiley   +1 more source

Long‐term prognosis is associated with residual disease after neoadjuvant systemic therapy but not with initial nodal status

BJS (British Journal of Surgery), EarlyView., 2020
This long‐term follow‐up study determined survival rates in a Swedish national cohort of 417 patients with breast cancer who all had neoadjuvant systemic therapy (NAST). Sentinel lymph node biopsy (SLNB) was performed before NAST in clinically node‐negative and after NAST in clinically node‐positive patients.
L. Zetterlund, F. Celebioglu, T. Hatschek, J. Frisell, J. de Boniface   +4 more
wiley   +1 more source

Adapting International Business Models for EU Projects: Macro- and Micro-Foundations of the Uppsala Model in Multinational Collaborations

Businesses
This study examines the adaptation of the Uppsala Model to enhance the management of European Union (EU)-funded projects, particularly focusing on the macro- and micro-foundational elements of the model.
Cheryl Marie Cordeiro, Erik Sindhøj
doaj   +1 more source

Memoriæ ergo scribebat : Nedslag i stambokssamlingen vid Uppsala universitetsbibliotek

, 2021
De så kallade stamböckerna (latin alba amicorum) är en föga uppmärksammad källa till den europeiska kulturhistorien. Sveriges största stambokssamling finns vid Uppsala universitetsbibliotek (UUB) och den är digitaliserad och katalogiserad i ”Alvin ...
Solling, Daniel, Cöllen, Sebastian
core  

Mitochondrial Localization of Cx26 Promotes Colorectal Cancer Malignancy and Exposes a Fatal Vulnerability to Drug Targeting

Advanced Science, EarlyView.
Mitochondrial localization of Cx26 emerges as a double‐edged sword in colorectal cancer. PIMT‐mediated methylation of Cx26 promotes its mitochondrial localization and stability. Mitochondrial Cx26 then facilitates ER‐mitochondria communication and Ca2+ signaling, thereby promoting metastatic progression. Bortezomib exploits this malignant adaptation by
Jie Wang, Lu Chen, Jia Qin, Xiaoning Wang, Sunlan Ye, Ning An, Mei Bai, Yan Shen, Xuefeng Wu, Qiang Xu   +9 more
wiley   +1 more source

Book reviews

Scandinavian Journal of Disability Research, 2009
'From Institutional Life to Community Participation. Ideas and Realities Concerning Support to Persons with Intellectual Disability' . Ericsson Kent Acta Universitatis Upsaliensis. Uppsala Studies in Education.
Mårten Söder, Mårten Söder
doaj   +1 more source

Frihet, kollegialitet, studentinflytande : Uppsala universitet under Eva Åkessons rektorat 2012–2020

, 2020
Uppsala universitet har under Eva Åkessons nioåriga rektorat, 2012 till 2020, upplevt ett omvälvande och nydanande skede. Internationaliseringen av både forskning och utbildning har varit påtaglig och nätverk har etablerats med framstående lärosäten i en
Frängsmyr, Carl
core  

Inhibition of MEKK3 Prevents Cerebral Cavernous Malformation Progression Via Restoring Endothelial Integrity and Restricting Microglial Activation

Advanced Science, EarlyView.
In this study, we demonstrate that aberrant MEKK3 signaling in endothelial cells and microglia drives the progression of cerebral cavernous malformations (CCMs). Furthermore, we identify DPDH as a potent small‐molecule MEKK3 inhibitor with substantial therapeutic potential for CCM treatment.
Weiwei Zheng, Suyun Yu, Liwenyu Chen, Jing Ma, Peiliang Shen, Chang Yu, Xiaoqing Xin, Qiuhong Shen, Jing Chen, Song Ke, Hao Liu, Xiaobing Jiang, Ruogu Qi, Juming Yan, Jia Li, Jaesung P. Choi, Yin Lu, Yang Zhao   +17 more
wiley   +1 more source