Results 61 to 70 of about 8,610 (171)

Development of deaminase-free T-to-S base editor and C-to-G base editor by engineered human uracil DNA glycosylase

bioRxiv
DNA base editors could enable direct editing of adenine (A), cytosine (C), or guanine (G), but there is no base editor for direct thymine (T) editing currently.
Huawei Tong, Haoqiang Wang, Nana Liu, Guoling Li, Yingsi Zhou, Danni Wu, Yun Li, Ming Jin, Xuchen Wang, Hengbin Li, Yinghui Wei, Yuan Yuan, Linyu Shi, Xuan Yao, Hui Yang   +14 more
semanticscholar   +1 more source

Studies of Trans-N-Glycosidase of Thermobacter Acidophilus and its Inhibition by 6-Azathymidine [PDF]

, 1959
[From the Introduction] The purpose of this investigation was to purify the enzyme trans-N-glycosidase from T. acidophilus and to study its specificity, optimum pH, and the effect of various other compounds, particularly azathymine and azathymidine, upon
Marsh, John C.
core   +1 more source

Uracil–DNA glycosylase UNG1 isoform variant supports class switch recombination and repairs nuclear genomic uracil

Nucleic Acids Research, 2019
UNG is the major uracil-DNA glycosylase in mammalian cells and is involved in both error-free base excision repair of genomic uracil and mutagenic uracil-processing at the antibody genes.
Antonio Sarno, Marie B Lundbæk, N. Liabakk, P. A. Aas, Robin Mjelle, Lars Hagen, M. M. Sousa, H. Krokan, B. Kavli   +8 more
semanticscholar   +1 more source

DNA Damage and Its Links to Neurodegeneration [PDF]

, 2017
The integrity of our genetic material is under constant attack from numerous endogenous and exogenous agents. The consequences of a defective DNA damage response are well studied in proliferating cells, especially with regards to the development of ...
Madabhushi, Ram, Pan, Ling, Tsai, Li-Huei   +2 more
core   +1 more source

Expression, Purification and Characterization of Ricin vectors used for exogenous antigen delivery into the MHC Class I presentation pathway [PDF]

, 2003
Disarmed versions of the cytotoxin ricin can deliver fused peptides into target cells leading to MHC class I-restricted antigen presentation [Smith et al. J Immunol 2002; 169:99-107].
Lord, J. Michael, Marsden, Catherine J., Roberts, Lynne M., Smith, Daniel C.   +3 more
core   +3 more sources

Inducible and constitutive promoters for genetic systems in Sulfolobus acidocaldarius [PDF]

, 2010
Central to genetic work in any organism are the availability of a range of inducible and constitutive promoters. In this work we studied several promoters for use in the hyperthermophilic archaeon Sulfolobus acidocaldarius. The promoters were tested with
AF Andersson, Alexander Wlodkowski, B Ehresmann, B Wiedenheft, C Haseltine, C Haseltine, D Barthelme, D Gotz, DW Grogan, G Lipps, Georg Lipps, IG Duggin, JM Lubelska, L Chen, L Deng, M Jonuscheit, M Wagner, MG Elferink, MS Reilly, N Kurosawa, O Wurtzel, Q She, RY Samson, S Berkner, S Berkner, S Berkner, Silvia Berkner, Sonja-Verena Albers, SV Albers, SV Albers, TD Brock, V Hoang, WS Maaty   +32 more
core   +2 more sources

The cytotoxic activity of ribosome-inactivating protein saporin-6 is attributed to its rRNA N-glycosidase and internucleosomal DNA fragmentation activities [PDF]

, 2002
Saporin-6 produced by the plant Saponaria officinalis belongs to the family of single chain ribosome-inactivating proteins. It potently inhibits protein synthesis in eukaryotic cells, by cleaving the N-glycosidic bond of a specific adenine in 28 S rRNA ...
Bagga, Shveta, Batra, Janendra K., Seth, Divya   +2 more
core   +1 more source

UEG Week 2025 Oral Presentations

United European Gastroenterology Journal, Volume 13, Issue S8, Page S7-S188, October 2025.
wiley   +1 more source

Mimicking damaged DNA with a small molecule inhibitor of human UNG2 [PDF]

, 2006
Human nuclear uracil DNA glycosylase (UNG2) is a cellular DNA repair enzyme that is essential for a number of diverse biological phenomena ranging from antibody diversification to B-cell lymphomas and type-1 human immunodeficiency virus infectivity ...
Ccp4, Daniel J. Krosky, Di Noia, Drohat, Drohat, Drohat, Erlanson, Halgunset, Heberling, James T. Stivers, Jiang, Kavli, Krokan, Kurian, L. Mario Amzel, Lauren Seiple, Lindahl, Lindahl, Malet-Martino, Maly, Mario A. Bianchet, Nilsen, Nilsen, Nilsen, Otwinoski, Parikh, Petersen-Mahrt, Priet, Rada, Seiple, Slupphaug, Stivers, Stivers, Suhman Chung, Werner   +34 more
core   +5 more sources

The Application of Multi-dimensional Fluorescence Imaging to Microfluidic Systems

, 2012
This thesis describes the application of multidimensional fluorescence imaging to microfluidic systems. The work focuses on time- and polarisation-resolved fluorescence microscopy to extract information from microchannel environments.
Robinson, Tom, Robinson, Tom
core   +1 more source