Results 151 to 160 of about 139,089 (266)

Oxidative Stress and DNA Epigenetic Modifications in Cancer: Mechanisms and Targeted Therapeutics

MedComm – Oncology, Volume 5, Issue 2, June 2026.
Reactive oxygen species (ROS) modulate DNA methyltransferases (DNMTs), ten‐eleven translocation family proteins (TETs) and their cofactors, reshaping 5‐methylcytosine (5mC)/5‐hydroxymethylcytosine (5hmC)/5‐formylcytosine (5fC) landscapes and gene expression in cancer cells. In turn, epigenetic control of antioxidant and metabolic pathways feeds back on
Xishan Yang, Qitai Chen, YuJie Yu, Yi Zang, Rujia Zheng, Zhe Zhang, Shuaijun Lu, Li Zhou   +7 more
wiley   +1 more source

Identification of TgENT1 as the TgUUT1 Uracil/Uridine Transporter of <i>Toxoplasma gondii</i>. [PDF]

Pathogens
Elati HAA, Ferreira Silva M, Sheiner L, de Koning HP.   +3 more
europepmc   +1 more source

The Lack of a COPII Cargo Receptor Erv14 Impacts Physiological Functions of the Vacuole in Saccharomyces cerevisiae

Traffic, Volume 27, Issue 2, June 2026.
Loss of the cargo receptor Erv14 in Saccharomyces cerevisiae results in sensitivity to calcium, zinc, neutral extracellular pH, and elevated temperature. Furthermore, cells deleted in the ERV14 exhibits vacuolar fragmentation, enlarged lipid droplets, and metabolic alterations. Ruiz Salas, J. L. (2026) https://BioRender.com/b65g523. ABSTRACT Erv14 is a
Paul Rosas‐Santiago, Jorge Luis Ruiz Salas, Elizabeth Cordoba, Francisco Vera‐López Portillo, Prisciluis Caheri Salas‐Navarrete, Jaime Arturo Pimentel Cabrera, Alfredo Martínez, Nayeli Imelda Roldan Ramírez, Dieter Chavelas Hernández, Andrés Saralegui‐Amaro, Martha Calahorra, Hana Sychrová, Olga Zimmermannová   +12 more
wiley   +1 more source

Anti-Toxoplasma activity of NBMPR is mediated through the inhibition of nucleoside and nucleobase transporters. [PDF]

Parasitol Res
Pan M, Tang SQ, Ge CC, Fan SJ, He HX, Bian MM, Shen B, Huang SY.   +7 more
europepmc   +1 more source

Engineering a Synthetic Formatotrophic Yeast With Enhanced Growth Capacity on Formate

Advanced Energy and Sustainability Research, Volume 7, Issue 5, May 2026.
Engineering Yeast for Growth on Formate and Methanol via Serine‐Centered C1 Coupling. By engineering serine metabolism and remodeling the rGly pathway, we rendered yeast growth strictly dependent on formate. This synthetic formatotrophy enables growth on dual‐C1 substrates by channeling formate into the central metabolism via serine deaminases and ...
Shuyuan Guo, Gulikezi Maimaitirexiati, Qiannan Zhang, Zhehao Jin, Kaidi Chen, Tiantian Zou, Xuemei Zhao, Xiangjian Liu, Zhenmin Bai, Dashuang Gao, Xudong Kong, Tao Yu   +11 more
wiley   +1 more source

B cell receptor stimulation inhibits class switch recombination through elevated DNA repair. [PDF]

DNA Repair (Amst)
Maul RW, McFleder RL, Cao Z, Norton DD, Ridani J, Barbulescu P, Martin A, Di Noia JM, Gearhart PJ.   +8 more
europepmc   +1 more source

A Novel Multimodal LC–MS/MS Panel for the Comprehensive Diagnosis of Neurometabolic Disorders in CSF

Journal of Inherited Metabolic Disease, Volume 49, Issue 3, May 2026.
ABSTRACT Metabolic testing of cerebrospinal fluid (CSF) is essential for early diagnosis of neurometabolic disorders. However, the large number of differential diagnoses, the phenotypic variance within a clinical picture, and the disease rarity complicate targeted metabolic diagnostics.
Stine Christ, Julia Rossmann, Sylvia Richter, Sven Garbade, Glynis Klinke, Nenad Blau, Georg Friedrich Hoffmann, Jürgen Günther Okun, Thomas Opladen   +8 more
wiley   +1 more source

Discovery of Tyrosinase Inhibitors from <i>Lysinibacillus</i> sp. JNUCC 52 via Genome Mining, Secondary Metabolites Profiling, and In Silico Analysis. [PDF]

Curr Issues Mol Biol
Liang X, Xu Y, Hyun CG.
europepmc   +1 more source

Sustainable Ethanol‐Based Reversed‐Phase Liquid Chromatography for Determination of Diltiazem pKa and Quantification with Integrated Green and White Analytical Metrics

ChemistryOpen, Volume 15, Issue 5, May 2026.
A sustainable reversed‐phase liquid chromatography method is developed for diltiazem analysis and pKadetermination. The study integrates green and white analytical chemistry frameworks to evaluate environmental impact and practicality. The Environmental, Performance, and Practicality Index is utilized as a comprehensive, holistic tool for the ...
Zehra Üstün, İlkay Konçe, Ebru Çubuk Demiralay   +2 more
wiley   +1 more source

Anti-Neuroinflammatory Effects of a Representative Low-Molecular-Weight Component Isolated from Codium fragile Through Inhibition of the NF-κB Pathway in Microglia and Macrophage Cells. [PDF]

Mar Drugs
Lee G, Jin Y, Lee SA, Lee SY, Lee H, Nan Z, Yoon CS, Lee DS.   +7 more
europepmc   +1 more source