Results 221 to 230 of about 149,629 (313)

PHYSICAL AND GENETIC CHARACTERIZATIONS OF CLONED FRAGMENTS OF BACILLUS SUBTILIS BACTERIOPHAGE SP01 DNA (HYDROXYMETHYL URACIL, THYMINE, HOST-KILLING)

, 1984
James F. Curran
openalex   +1 more source

Untersuchungen zum Ursprung der Substratspezifität von Enzymen der Amidohydrolase‐Superfamilie

Angewandte Chemie, Volume 138, Issue 4, 22 January 2026.
Umfassende Analysen zweier Enzymklassen aus der Amidohydrolase‐Superfamilie (AHS) ergaben, dass die Katalyse über eine 1,4‐ bzw. 1,6‐nukleophile konjugierte Addition abläuft und diese Eigenschaft die Substratspezifität bestimmt. Obwohl alle Substrate und Produkte vollständig achiral sind, führt dieser mechanistische Unterschied zu einer invertierten ...
Lukas Drexler, Torben F. Fürtges, Till Rudack, Reinhard Sterner   +3 more
wiley   +1 more source

Adjuvant Tegafur-Uracil Improves Survival in Low-Risk, Mismatch Repair Proficient Stage IIA Colon Cancer: A Propensity Score-Matched Analysis. [PDF]

Life (Basel)
Cheng MC, Lee HL, Lai SW, Chen JH, Chen PH.   +4 more
europepmc   +1 more source

On the Origin of Substrate Specificity of Enzymes from the Amidohydrolase Superfamily

Angewandte Chemie International Edition, Volume 65, Issue 4, 22 January 2026.
Comprehensive analyses of two enzyme classes from the amidohydrolase superfamily (AHS) revealed that catalysis proceeds either via 1,4 or 1,6 nucleophilic conjugate addition and that this property defines substrate specificity. Moreover, although all substrates and products are entirely achiral, this mechanistic difference results in an inverted ...
Lukas Drexler, Torben F. Fürtges, Till Rudack, Reinhard Sterner   +3 more
wiley   +1 more source

Bridging mechanism and design: modern medicinal chemistry approaches to thymidylate synthase inhibitors. [PDF]

RSC Adv
Al-Karmalawy AA, Eissa ME, Yousef TA, Al Khatib AO, Hawas SS.   +4 more
europepmc   +1 more source

A pilot study of tegafur-uracil maintenance on survival in patients with esophageal squamous cell carcinoma following definitive chemoradiotherapy. [PDF]

Sci Rep
Huang TC, Chen JH, Hsieh JC, Lien MY, Ho CL, Chang PH, Hsieh MC.   +6 more
europepmc   +1 more source

Uracil Derivatives and Related Compounds. VII. : Synthesis and Anti-inflammatory Activity of Bucolome's Related Compounds (2)

, 1969
Shigeo Senda, Hiroshi Izumi, Takeo Tanimoto, Hajimè Fujimura   +3 more
openalex   +2 more sources

Metabolomic profiling of patients with lupus nephritis reveals unique metabolites that are modulated through type I interferon inhibition by anifrolumab treatment in a phase 2 trial. [PDF]

RMD Open
Gavin PG, Allman EL, Jayne D, Mysler E, Amoura Z, Di Poto C, Tian X, Hess S, Csomor E, Brohawn PZ, Muthas D, Platt A, Anzillotti C, Stone H, Seth A, Woollard K, Al-Mossawi H, Lindholm C, Ferrari N.   +18 more
europepmc   +1 more source

Diels-Alder Reactions of a Styrene-Isocyanate: Unexpected Formation of a Pyridinone and Uracil

, 2008
Gregory A. Gfesser, David N. Whittern, Marlon Cowart, Ramin Faghih   +3 more
openalex   +1 more source

Uracil excision by endogenous SMUG1 glycosylase promotes efficient Ig class switching and impacts on A:T substitutions during somatic mutation [PDF]

, 2014
Felix A. Dingler, Kristin Kemmerich, Michael S. Neuberger, Cristina Rada   +3 more
openalex   +1 more source