Results 131 to 140 of about 5,544 (172)
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Cardiovascular Safety of Urate Lowering Therapies
Current Rheumatology Reports, 2019The effect of urate lowering treatment (ULT) on cardiovascular (CV) risk and mortality in gout has been a topic of interest. This review discusses the CV effect of ULT and comparative CV safety among ULT agents.The mechanism linking gout with CV risk is not fully understood but seems multifactorial involving hyperuricemia, xanthine oxidase (XO ...
Eun Ha, Kang, Seoyoung C, Kim
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Update on emerging urate-lowering therapies
Current Opinion in Rheumatology, 2009To discuss currently available urate-lowering therapeutic options for gout in the United States and newer therapeutic initiatives in development.Currently available urate-lowering drugs include allopurinol and probenecid. These drugs are effective but are often underdosed or underutilized, and caution must be taken in patients with multiple ...
Saima, Chohan, Michael A, Becker
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Potential Dangers of Serum Urate-Lowering Therapy
The American Journal of Medicine, 2019In observational studies, high serum urate levels are associated with adverse outcomes, including mortality. However, the hypothesis that urate-lowering may improve nongout outcomes has not been confirmed by placebo-controlled clinical trials. On the contrary, 7 recent placebo-controlled trials of urate-lowering drugs with different mechanisms of ...
Maria Vanessa Perez-Gomez +5 more
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Urate‐Lowering Therapy for Gout: Focus on Febuxostat
Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy, 2010Gout is a common, painful, and often debilitating rheumatologic disorder that remains one of the few arthritic conditions that can be diagnosed with certainty and cured with appropriate therapy. Allopurinol is the most frequently prescribed agent for gout in the United States.
Bryan L, Love +3 more
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Expert opinion on emerging urate-lowering therapies
Expert Opinion on Emerging Drugs, 2018There has been a resurgence in gout therapeutics in the last decade, not only for the management of gout flares, but also for the treatment of hyperuricemia. This editorial summarizes new, emerging therapies for people with gout. Areas covered: We review several new therapies for gout, including those that are focused on lowering serum urate ...
Lisa K, Stamp +2 more
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Arthritis & Rheumatology, 2022
ObjectiveTo determine whether a therapeutic approach of intensive serum urate lowering results in improved bone erosion scores in patients with erosive gout.MethodsWe undertook a 2‐year, double‐blind randomized controlled trial of 104 participants with erosive gout who were receiving serum urate–lowering therapy orally and who had serum urate levels of
Nicola Dalbeth +12 more
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ObjectiveTo determine whether a therapeutic approach of intensive serum urate lowering results in improved bone erosion scores in patients with erosive gout.MethodsWe undertook a 2‐year, double‐blind randomized controlled trial of 104 participants with erosive gout who were receiving serum urate–lowering therapy orally and who had serum urate levels of
Nicola Dalbeth +12 more
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Urate-Lowering Therapy and Chronic Kidney Disease Progression
New England Journal of Medicine, 2020The prevalence and severity of chronic kidney disease (CKD) has been increasing for decades. Because of its tremendous financial and health burden, both to persons and to health systems, mitigation...
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Adherence and persistence to urate-lowering therapies in the Irish setting
Clinical Rheumatology, 2014To identify adherence and persistence levels with urate-lowering therapies using the national administrative pharmacy claim database. This was a retrospective, pharmacy claims-based analysis of dispensed anti-gout medications on the Irish national HSE-PCRS scheme database between January 2008 and December 2012.
Bernie, McGowan +3 more
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Ultrasound in gout: A useful tool for following urate-lowering therapy
Joint Bone Spine, 2015We aimed to determine the ability of ultrasonography (US) to show decrease or disappearance of urate deposits in gouty patients requiring urate-lowering therapy (ULT).To be included in this prospective single-centre study, patients needed toexhibit (1) proven gout by monosodic urate (MSU) crystals in synovial fluid and (2) US-evidenced urate deposits ...
Sébastien, Ottaviani +5 more
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Influence of urate-lowering therapies on renal handling of uric acid
Clinical Rheumatology, 2014The purpose of this study is to investigate the effect of urate-lowering therapies (ULTs) on renal uric acid excretion in gout patients. This prospective observational study involved 106 primary gout patients and 51 healthy controls. Gout patients received ULT with either xanthine oxidase inhibitors or the uricosuric agent benzbromarone.
Lili, Ma +6 more
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