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Controversies in Urate-Lowering Therapy for Gout: A Comprehensive Review
Gout, Urate, and Crystal Deposition DiseaseGout is the most common inflammatory arthritis. Treatment of gout includes anti-inflammatory and urate-lowering agents. Robust guidelines by the American College of Rheumatology, the European Alliance of Associations for Rheumatology and other committees
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Cardiovascular Safety of Urate Lowering Therapies
Current Rheumatology Reports, 2019The effect of urate lowering treatment (ULT) on cardiovascular (CV) risk and mortality in gout has been a topic of interest. This review discusses the CV effect of ULT and comparative CV safety among ULT agents.The mechanism linking gout with CV risk is not fully understood but seems multifactorial involving hyperuricemia, xanthine oxidase (XO ...
Eun Ha, Kang, Seoyoung C, Kim
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Update on emerging urate-lowering therapies
Current Opinion in Rheumatology, 2009To discuss currently available urate-lowering therapeutic options for gout in the United States and newer therapeutic initiatives in development.Currently available urate-lowering drugs include allopurinol and probenecid. These drugs are effective but are often underdosed or underutilized, and caution must be taken in patients with multiple ...
Saima, Chohan, Michael A, Becker
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Journal of NephrologyInternational audienceBackground: Hyperuricemia is a hallmark of gout and a suspected risk factor for the progression of chronic kidney disease (CKD). However, the impact of urate-lowering therapy on CKD progression is subject to debate. The objective of
Pablo Antonio Urena Torres +2 more
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Urate‐Lowering Therapy for Gout: Focus on Febuxostat
Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy, 2010Gout is a common, painful, and often debilitating rheumatologic disorder that remains one of the few arthritic conditions that can be diagnosed with certainty and cured with appropriate therapy. Allopurinol is the most frequently prescribed agent for gout in the United States.
Bryan L, Love +3 more
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Clinical interventions to improve adherence to urate-lowering therapy in patients with gout: a systematic review [PDF]
International Journal of Pharmacy Practice, 2022 The aim of this study was to systematically review and compare the quantitative effect of clinical interventions designed to improve adherence to urate-lowering therapy.
Dyfrig A Hughes +2 more
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Expert opinion on emerging urate-lowering therapies
Expert Opinion on Emerging Drugs, 2018There has been a resurgence in gout therapeutics in the last decade, not only for the management of gout flares, but also for the treatment of hyperuricemia. This editorial summarizes new, emerging therapies for people with gout. Areas covered: We review several new therapies for gout, including those that are focused on lowering serum urate ...
Lisa K, Stamp +2 more
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Adherence and persistence to urate-lowering therapies in the Irish setting
Clinical Rheumatology, 2014To identify adherence and persistence levels with urate-lowering therapies using the national administrative pharmacy claim database. This was a retrospective, pharmacy claims-based analysis of dispensed anti-gout medications on the Irish national HSE-PCRS scheme database between January 2008 and December 2012.
Bernie, McGowan +3 more
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Urate-Lowering Therapy and Chronic Kidney Disease Progression
New England Journal of Medicine, 2020The prevalence and severity of chronic kidney disease (CKD) has been increasing for decades. Because of its tremendous financial and health burden, both to persons and to health systems, mitigation...
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Ultrasound in gout: A useful tool for following urate-lowering therapy
Joint Bone Spine, 2015We aimed to determine the ability of ultrasonography (US) to show decrease or disappearance of urate deposits in gouty patients requiring urate-lowering therapy (ULT).To be included in this prospective single-centre study, patients needed toexhibit (1) proven gout by monosodic urate (MSU) crystals in synovial fluid and (2) US-evidenced urate deposits ...
Sébastien, Ottaviani +5 more
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