An Optical Urate Biosensor Based on Urate Oxidase and Long-Lifetime Metalloporphyrins [PDF]
Sensors, 2020 Gout is a condition that affects over 8 million Americans. This condition is characterized by severe pain, and in more advanced cases, bone erosion and joint destruction.
Tokunbo Falohun, Michael J. McShane
doaj +5 more sources
Thermostable and Long-Circulating Albumin-Conjugated Arthrobacter globiformis Urate Oxidase [PDF]
Pharmaceutics, 2021 Urate oxidase derived from Aspergillus flavus has been investigated as a treatment for tumor lysis syndrome, hyperuricemia, and gout. However, its long-term use is limited owing to potential immunogenicity, low thermostability, and short circulation time
Byungseop Yang, Inchan Kwon
doaj +2 more sources
Randomized, Double-Blind, Placebo-Controlled, Phase I, Dose- Escalation Study to Evaluate the Tolerance, Pharmacokinetics, Pharmacodynamics and Immunogenicity of PEGylated Urate Oxidase for Injection in Healthy Adults and Hyperuricemia Volunteers: Study Protocol [PDF]
Diabetes, Metabolic Syndrome and Obesity, 2023 Feifei Sun,1,* Chenjing Wang,1,* Yi Xu,1 Pingping Lin,1 Yaozhong Cao,2 Jiahui Zhang,3 Xin Li,1 Xin Jiang,1 Yao Fu,1 Yu Cao1 1Clinical Trials Center, The Affiliated Hospital of Qingdao University, Qingdao, Shandong, People’s Republic of China ...
Sun F +9 more
doaj +2 more sources
Oral Treatment With an Engineered Uricase, ALLN-346, Reduces Hyperuricemia, and Uricosuria in Urate Oxidase-Deficient Mice [PDF]
Frontiers in Medicine, 2020 Limitations in efficacy and/or tolerance of currently available urate-lowering therapies (ULTs), such as oral xanthine oxidase inhibitors, uricosurics, and intravenous uricase agents contribute to the development of refractory gout.
Kateryna Pierzynowska +11 more
doaj +2 more sources
Engineered Escherichia coli Nissle 1917 with urate oxidase and an oxygen-recycling system for hyperuricemia treatment [PDF]
Gut Microbes, 2022 Hyperuricemia is the second most prevalent metabolic disease to human health after diabetes. Only a few clinical drugs are available, and most of them have serious side effects.
Rui Zhao +7 more
doaj +2 more sources
Exploring the impact of taurine on the biochemical properties of urate oxidase: response surface methodology and molecular dynamics simulation [PDF]
Journal of Biological EngineeringThis paper investigates the impact of taurine as an additive on the structural and functional stability of urate oxidase. First, the effect of the processing parameters for the stabilization of Urate Oxidase (UOX) using taurine was examined using the ...
Parisa Shahmoradipour +2 more
doaj +2 more sources
Urate oxidase from tea microbe Colletotrichum camelliae is involved in the caffeine metabolism pathway and plays a role in fungal virulence [PDF]
Frontiers in Nutrition, 2023 Tea is one of the most well-known, healthy beverages in the world. Tea plants produce caffeine as a secondary metabolite. Colletotrichum camelliae is one of the most important microbes frequently isolated from tea fields, and it causes anthracnose ...
Shengnan He +6 more
doaj +2 more sources
Azide inhibition of urate oxidase. [PDF]
Acta Crystallogr F Struct Biol Commun, 2014 The inhibition of urate oxidase (UOX) by azide was investigated by X-ray diffraction techniques and compared with cyanide inhibition. Two well characterized sites for reagents are present in the enzyme: the dioxygen site and the substrate-binding site.
Gabison L, Colloc'h N, Prangé T.
europepmc +5 more sources
Directed evolution to improve the catalytic efficiency of urate oxidase from Bacillus subtilis. [PDF]
PLoS ONE, 2017 Urate oxidase is a key enzyme in purine metabolism and catalyzes the oxidation of uric acid to allantoin. It is used to treat hyperuricemia and gout, and also in a diagnostic kit.
Wenjie Li +7 more
doaj +2 more sources
Disease Models & Mechanisms, 2021 Epidemiological research has shown that elevated serum urate concentration is a risk factor for the development of kidney disease; however, the mechanisms underlying this process have not yet been elucidated.
Mian Wu +5 more
doaj +2 more sources