Results 111 to 120 of about 14,896 (211)

The Effective Control of Hyperuricemia in Cancer Patients: A New Recombinant Conjugated Variant of Urate Oxidase. [PDF]

Asian Pac J Cancer Prev, 2021
Najjari A, Shahbazmohammadi H, Omidinia E, Movafagh AM.   +3 more
europepmc   +1 more source

Xanthine oxidoreductase in essential hypertension and metabolic syndrome : Experimental studies on rodent models [PDF]

, 2009
Hypertension, obesity, dyslipidemia and dysglycemia constitute metabolic syndrome, a major public health concern, which is associated with cardiovascular mortality.
Laakso, Juha
core  

Chemical Modification of Cysteine with 3-Arylpropriolonitrile Improves the In Vivo Stability of Albumin-Conjugated Urate Oxidase Therapeutic Protein. [PDF]

Biomedicines, 2021
Yang B, Kwon I.
europepmc   +1 more source

Progress in animal models for studying hyperuricemia

Frontiers in Pharmacology
Hyperuricemia (HUA) is a prevalent metabolic disorder driven by dysregulated purine metabolism and impaired urate excretion, and robust animal models are critical for elucidating its pathophysiology and guiding therapy development.
Senyue Zhang, Kaiqing Li, Hu Zhang, Tong Fu, Yanchun Ma, Shuxiang Zhang, Guoli Xing, Ying Tong   +7 more
doaj   +1 more source

Enhancement of Thermostability of <i>Aspergillus flavus</i> Urate Oxidase by Immobilization on the Ni-Based Magnetic Metal-Organic Framework. [PDF]

Nanomaterials (Basel), 2021
Motamedi N, Barani M, Lohrasbi-Nejad A, Mortazavi M, Riahi-Medvar A, Varma RS, Torkzadeh-Mahani M.   +6 more
europepmc   +1 more source

Management of hyperuricemia in gout: focus on febuxostat

Clinical Interventions in Aging, 2010
Mattheus K Reinders1, Tim L Th A Jansen21Clinical Pharmacy, Atrium Medisch Centrum Parkstad, Heerlen, The Netherlands; 2Rheumatology, Medisch Centrum Leeuwarden, Leeuwarden, The NetherlandsAbstract: Gout is the most common inflammatory arthritis in an ...
Mattheus K Reinders, Tim L Th A Jansen
doaj  

Heterologous expression of recombinant urate oxidase using the intein-mediated protein purification in Pichia pastoris. [PDF]

3 Biotech, 2021
Khaleghi R, Asad S.
europepmc   +1 more source

Rasburicase represents a new tool for hyperuricemia in tumor lysis syndrome and in gout

International Journal of Medical Sciences, 2007
Hyperuricemia is a feature of several pathologies and requires an appropriate and often early treatment, owing to the severe consequences that it may cause.
Lisa Cammalleri, Mariano Malaguarnera
doaj  

Inhibiting Hepatocyte Uric Acid Synthesis and Reabsorption Ameliorates Acetaminophen-Induced Acute Liver Injury in MiceSummary

Cellular and Molecular Gastroenterology and Hepatology
Background & Aims: Acetaminophen (APAP) overdose is the most common cause of drug-induced liver injury worldwide. Uric acid (UA) is involved in sterile inflammation in many organs, but its role in APAP-induced liver injury remains elusive.
Chenxi Tang, Li Cen, Hang Zeng, Xiaofen Zhang, Peihao Liu, Yishu Chen, Xin Song, Bingru Lin, Xuequn Zhang, Chaohui Yu, Chengfu Xu   +10 more
doaj   +1 more source

A high-performance electrochemical biosensor using an engineered urate oxidase.

Chem Commun (Camb), 2023
Wei Z, Knaus T, Liu Y, Zhai Z, Gargano AFG, Rothenberg G, Yan N, Mutti FG.   +7 more
europepmc   +1 more source