Results 121 to 130 of about 14,896 (211)

Treatment of Gout in Patients with CrCl ≤30 mL/min and/or on Hemodialysis: A Review

Rheumato
Gout is highly prevalent in patients with chronic kidney disease (CKD) and end-stage renal disease (ESRD), owing to impaired uric acid excretion. However, treating gout in this population is challenging due to concerns about medication safety and ...
Fares Saliba, Omar Mourad, Jonathan Mina, Fadi Haddadin, Laurence Aoun, Shaza Almardini, Saif Abu-baker, Koushik Sangaraju, Gaetano Di Pietro, Daniel Gaballa, Suzanne El-sayegh   +10 more
doaj   +1 more source

Influence of xanthine oxidase inhibitors on all-cause mortality in adults: a systematic review and meta-analysis

Cardiology Journal
Xanthine oxidase inhibitors, including allopurinol and febuxostat, are the first-line treatment of hyperuricemia. This meta-analysis investigated the association between urate-lowering therapy and all-cause mortality in different chronic diseases to ...
Marcin M. Nowak, Mariusz Niemczyk, Sławomir Gołębiewski, Leszek Pączek   +3 more
doaj   +1 more source

Joint neutron/X-ray crystal structure of a mechanistically relevant complex of perdeuterated urate oxidase and simulations provide insight into the hydration step of catalysis. [PDF]

IUCrJ, 2021
McGregor L, Földes T, Bui S, Moulin M, Coquelle N, Blakeley MP, Rosta E, Steiner RA.   +7 more
europepmc   +1 more source

Hederagenin's uric acid-lowering effects in hyperuricemic mice: Mechanistic insights from molecular docking and in vivo analysis.

PLoS ONE
This study explored the uric acid-lowering effects of hederagenin (HD) through molecular docking analysis and a chronic hyperuricemia (HUA) mouse model.
Ping Chen, Ya-Ni Tian, Jing-Tao Wang, Xiang-Lin Yin, Bao-Sheng Guan, Xue Bai   +5 more
doaj   +1 more source

Enhancement of Pharmaceutical Urate Oxidase Thermostability by Rational Design of De Novo Disulfide Bridge. [PDF]

Iran J Biotechnol, 2020
Rezaeian Marjani L, Imani M, Zarei Jaliani H.   +2 more
europepmc   +1 more source

Organization of urate oxidase in peroxisomal nucleoids [PDF]

FEBS Letters, 1978
Antonenkov, V.D., Panchenko, L.F.
openaire   +2 more sources

Revisiting the Effects of Xenon on Urate Oxidase and Tissue Plasminogen Activator: No Evidence for Inhibition by Noble Gases. [PDF]

Front Mol Biosci, 2020
Cahill J, Ruffing AM.
europepmc   +1 more source

Correction: Motamedi et al. Enhancement of Thermostability of <i>Aspergillus flavus</i> Urate Oxidase by Immobilization on the Ni-Based Magnetic Metal-Organic Framework. <i>Nanomaterials</i> 2021, <i>11</i>, 1759. [PDF]

Nanomaterials (Basel)
Motamedi N, Barani M, Lohrasbi-Nejad A, Mortazavi M, Riahi-Medvar A, Varma RS, Torkzadeh-Mahani M.   +6 more
europepmc   +1 more source

Metal-ligand dual-site single-atom nanozyme mimicking urate oxidase with high substrates specificity. [PDF]

Nat Commun
Wang K, Hong Q, Zhu C, Xu Y, Li W, Wang Y, Chen W, Gu X, Chen X, Fang Y, Shen Y, Liu S, Zhang Y.   +12 more
europepmc   +1 more source

Urate oxidase (rasburicase) for treatment of severe tophaceous gout [PDF]

, 2017
Vogt, Bruno
core