Results 161 to 170 of about 14,896 (211)

Efficacy of urate oxidase (uricozyme) in tumour lysis induced urate nephropathy

Clinical & Laboratory Haematology, 1998
Urate oxidase (uricozyme) is an enzyme of non-human origin capable of oxidizing human uric acid to allantoin, a highly soluble product at renal tubule pH. We report its efficacy in three patients with acute urate nephropathy due to tumour lysis in chronic lymphatic leukaemia and high grade lymphoma.
M, Leach, R M, Parsons, J T, Reilly, D A, Winfield   +3 more
openaire   +2 more sources

Studies on mouse liver urate oxidase

Histochemie, 1973
The localization of urate oxidase in mouse liver was investigated by fluorescent antibody technique. The fluorescence was observed in the cytoplasm and fine granules scattering throughout the cytoplasm of liver cells. The diffuse cytoplasmic fluorescence around the central vein was somewhat stronger than that of the medial and outer zone of hepatic ...
openaire   +4 more sources

Polymorphism of Urate Oxidase in PEG Solutions

Crystal Growth & Design, 2005
In a previous paper, we have shown that three different crystal habits exist in the urate oxidase/PEG phase diagram (Vivares, D.; Bonnete, F. J. Phys. Chem. B 2004, 108, 6498-6507). In the present paper, we show with a temperature-controlled device that these different crystal habits correspond to two polymorphs (namely, S/N and P).
Vivares, D., Veesler, S., Astier, J.P., Bonnete, F.   +3 more
openaire   +2 more sources

Glucocorticoid regulation of rat liver urate oxidase

Journal of Cellular Biochemistry, 1991
AbstractUrate oxidase, an enzyme involved in purine catabolism, comprises the crystalline core of rat liver peroxisomes. An affinity‐purified monospecific antibody was developed to study the expression of urate oxidase protein levels. Immunoreactive urate oxidase was not detectable in prenatal liver; however, it is present at low levels after birth ...
L S, Raab, G L, Decker, A J, Jonas, M A, Kaetzel, J R, Dedman   +4 more
openaire   +2 more sources

HYPOURICAEMIC EFFECT OF POLYETHYLENEGLYCOL MODIFIED URATE OXIDASE

The Lancet, 1981
Abstract Uricase from Candida utilis was covalently attached to polyethyleneglycol (PEG). The modification of 71% of the amino groups in the uricase molecule produced a preparation retaining 11% of activity which did not elicit an antibody response in mice or man.
S, Davis, Y K, Park, A, Abuchowski, F F, Davis   +3 more
openaire   +2 more sources

Phase diagram for a model of urate oxidase

The Journal of Chemical Physics, 2007
Urate oxidase from Asperigillus flavus has been shown to be a model protein for studying the effects of polyethylene glycol (PEG) on the crystallization of large proteins. Extensive experimental studies based on small angle x-ray scattering [Vivarès and Bonneté, J. Phys. Chem.
N, Wentzel, D L, Pagan, J D, Gunton
openaire   +2 more sources

Immunological aspects of urate oxidase therapy in hyperuricaemia

Irish Journal of Medical Science, 1977
The immunological relationship between urate oxidase (uricase) prepared from microbiological and animal sources was studied. The enzymes from these two groups were found to be immunologically unrelated. Within each group cross reaction did occur; cross reactivity was frequent among the enzymes from animal sources.
D A, Fitzpatrick, O, FitzGerald, K F, McGeeney   +2 more
openaire   +2 more sources

Cloning a cDNA for Drosophila melanogaster urate oxidase

Gene, 1986
A cDNA library from third-instar larval Malpighian tubules of Drosophila melanogaster was constructed and screened for urate oxidase (UO) clones by hybridization selection. The coding sequence for UO was mapped by in situ hybridization to position 28C on the left arm of chromosome 2.
L G, Kral, D H, Johnson, J B, Burnett, T B, Friedman   +3 more
openaire   +2 more sources

Catalase deficiency may complicate urate oxidase (rasburicase) therapy

Free Radical Research, 2007
Patients with low (inherited and acquired) catalase activities who are treated with infusion of uric acid oxidase because they are at risk of tumour lysis syndrome may experience very high concentrations of hydrogen peroxide. They may suffer from methemoglobinaemia and haemolytic anaemia which may be attributed either to deficiency of glucose-6 ...
László, Góth, N William, Bigler
openaire   +2 more sources

Polymorphism of microcrystalline urate oxidase fromAspergillus flavus

Acta Crystallographica Section D Biological Crystallography, 2010
Different polymorphs of rasburicase, a recombinant urate oxidase enzyme (Uox) fromAspergillus flavus, were obtained as a series of polycrystalline precipitates. Different crystallization protocols were followed in which the salt type, pH and polyethylene glycol 8000 (PEG 8000) concentration were varied. The related crystalline phases were characterized
Collings, I., Watier, Y., Giffard, M., Dagogo, S., Kahn, R., Bonneté, F., Wright, J.P., Fitch, A.N., Margiolaki, I.   +8 more
openaire   +3 more sources