Uricosuric, antioxidant, and anti-inflammatory properties of Pandanus amaryllifolius Roxb. extract against potassium oxonate-induced hyperuricemia in rats [PDF]
Scientific ReportsHigh serum uric acid (HUA) is linked to gout, fatty liver, and insulin resistance. Anti-hyperuricemic drugs were designed to lower uric acid production and/or inhibit urate reabsorption by renal and extra-renal tissues. While Pandanus amaryllifolius Roxb.
Panan Suntornsaratoon +6 more
doaj +2 more sources
Therapeutic Advances in Musculoskeletal DiseaseGout is a common and painful inflammatory arthritis caused by monosodium urate crystal deposition into joints in the setting of hyperuricemia. Recent reports indicate an increase in prevalence and incidence of gout worldwide.
Kate L. McCarty +2 more
doaj +2 more sources
Peroxisomes in intestinal and gallbladder epithelial cells of the stickleback, Gasterosteus aculeatus L. (Teleostei) [PDF]
, 1988 The occurrence of microbodies in the epithelial cells of the intestine and gallbladder of the stickleback, Gasterosteus aculeatus L., is described. In the intestine the organelles are predominantly located in the apical and perinuclear zone of the cells ...
AJH Ruiter de +23 more
core +7 more sources
Urate Oxidase in Primate Phylogenesis [PDF]
European Journal of Biochemistry, 1970 Several genera of New World monkeys have high uric acid concentrations in serum and urine comparable to man and the higher apes. Like man these animals lack urate oxidase activity in liver tissue. The purine metabolism of these non‐human primates appears to be similar to that of man as exemplified by fasting‐induced hyperuricemia.
P, Christen +3 more
openaire +2 more sources
Eicosapentaenoic acid and oxypurinol in the treatment of muscle wasting in a mouse model of cancer cachexia [PDF]
, 2012 Cancer cachexia is a wasting condition, driven by systemic inflammation and oxidative stress. This study investigated eicosapentaenoic acid (EPA) in combination with oxypurinol as a treatment in a mouse model of cancer cachexia. Mice with cancer cachexia
Hinch, Edward +4 more
core +15 more sources
Enzymatic Activity as New Moorsh-Forming Process Indicators of Peatlands
Agronomy, 2021 The aim of this study is to comprehensively assess the change in oxidoreductive enzyme activities, due to the potential in catalyzing oxidation and reduction reactions, as the basic processes on undrained and drained peat soils. On undrained peatlands, a
Lech W. Szajdak +2 more
doaj +1 more source
Effect of allopurinol on phosphocreatine recovery and muscle function in older people with impaired physical function:a randomised controlled trial [PDF]
, 2020 Background: Allopurinol has vascular antioxidant effects and participates in purinergic signalling within muscle. We tested whether allopurinol could improve skeletal muscle energetics and physical function in older people with impaired physical ...
Cavin, Ian +10 more
core +2 more sources
The neutron structure of urate oxidase resolves a long-standing mechanistic conundrum and reveals unexpected changes in protonation. [PDF]
PLoS ONE, 2014 Urate oxidase transforms uric acid to 5-hydroxyisourate without the help of cofactors, but the catalytic mechanism has remained enigmatic, as the protonation state of the substrate could not be reliably deduced.
Esko Oksanen +4 more
doaj +1 more source
Urate-lowering drugs in the treatment of gout: The unknown about the known
Научно-практическая ревматология, 2021 The main direction of drug therapy for gout and other diseases associated with hyperuricemia is the long-term use of drugs aimed at correcting the level of uric acid.
T. S. Panevin +2 more
doaj +1 more source
Uric acid enhances longevity and endurance and protects the brain against ischemia [PDF]
, 2020 Among mammals, there is a positive correlation between serum uric acid (UA) levels and life span. Humans have high levels of UA because they lack a functional urate oxidase (UOX) enzyme that is present in shorter lived mammals.
Argüelles Castilla, Sandro +6 more
core +1 more source