Results 21 to 30 of about 14,896 (211)
Urate oxidase purification by salting-in crystallization: towards an alternative to chromatography.
PLoS ONE, 2011 BackgroundRasburicase (Fasturtec® or Elitek®, Sanofi-Aventis), the recombinant form of urate oxidase from Aspergillus flavus, is a therapeutic enzyme used to prevent or decrease the high levels of uric acid in blood that can occur as a result of ...
Marion Giffard +5 more
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Quantification of Uric Acid or Xanthine in Plant Samples
Bio-Protocol, 2015 We developed this protocol to assay and quantify the content of uric acid or xanthine in various tissues of Arabidopsis thaliana mutant lines with defective urate oxidase or xanthine dehydrogenase1 and in their complementation and suppressor lines (Hauck
Oliver Hauck, Claus-Peter Witte
doaj +1 more source
Urate and its transgenic depletion modulate neuronal vulnerability in a cellular model of Parkinson's disease. [PDF]
PLoS ONE, 2012 Urate is a major antioxidant as well as the enzymatic end product of purine metabolism in humans. Higher levels correlate with a reduced risk of developing Parkinson's disease (PD) and with a slower rate of PD progression.
Sara Cipriani +5 more
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Lesinurad, a novel, oral compound for gout, acts to decrease serum uric acid through inhibition of urate transporters in the kidney. [PDF]
, 2016 BackgroundExcess body burden of uric acid promotes gout. Diminished renal clearance of uric acid causes hyperuricemia in most patients with gout, and the renal urate transporter (URAT)1 is important for regulation of serum uric acid (sUA) levels.
Girardet, Jean-Luc +12 more
core +2 more sources
Hyperuricemia and urate nephropathy in urate oxidase-deficient mice. [PDF]
Proceedings of the National Academy of Sciences, 1994 Urate oxidase, or uricase (EC 1.7.3.3), is a purine metabolic enzyme that catalyzes the conversion of uric acid to allantoin in most mammals except humans and certain other primates. The loss of urate oxidase in the human during primate evolution predisposes man to hyperuricemia, a metabolic disturbance that can lead to gouty arthritis and renal stones.
X, Wu +7 more
openaire +2 more sources
ACVIM Small Animal Consensus Recommendations on the Treatment and Prevention of Uroliths in Dogs and Cats. [PDF]
, 2016 In an age of advancing endoscopic and lithotripsy technologies, the management of urolithiasis poses a unique opportunity to advance compassionate veterinary care, not only for patients with urolithiasis but for those with other urinary diseases as well.
Adams, LG +5 more
core +1 more source
Disrupted and transgenic urate oxidase alter urate and dopaminergic neurodegeneration [PDF]
Proceedings of the National Academy of Sciences, 2012 Urate is the end product of purine metabolism in humans, owing to the evolutionary disruption of the gene encoding urate oxidase (UOx). Elevated urate can cause gout and urolithiasis and is associated with cardiovascular and other diseases. However, urate also possesses antioxidant and neuroprotective properties.
Xiqun, Chen +6 more
openaire +2 more sources
EBioMedicine, 2018 Background: Epidemiological, laboratory and clinical studies have established an association between elevated urate and high blood pressure (BP). However, the inference of causality remains controversial. A naturally occurring antioxidant, urate may also
Xiqun Chen +12 more
doaj +1 more source
مجله دانشگاه علوم پزشکی گرگان, 2021 Background and Objective: Streptomyces are gram-positive and aerobic bacterial strains that are isolated from different sources. Streptomyces have the ability to produce secondary metabolites and biologically active substances and are therefore very ...
Nayyereh Sadat Jenaban +2 more
doaj
Arthritis Research & Therapy, 2022 Objective Linked metabolic and cardiovascular comorbidities are prevalent in hyperuricemia and gout. For mechanistic insight into impact on inflammatory processes and cardiometabolic risk factors of xanthine oxidase inhibitor urate-lowering therapy (ULT)
Monica Guma +11 more
doaj +1 more source