Experience with febuxostat in a patient with severe disabling gout
Современная ревматология, 2017 Gout is a chronic disease that frequently leads to disability if urate-lowering therapy is inefficient. The paper presents the positive experience with febuxostat, a novel non-purine xanthine oxidase inhibitor, in a young patient with disabling chronic ...
M. S. Eliseev, R. U. Shayakhmetova
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Experimental Physiology, Volume 111, Issue 3, Page 1483-1497, 1 March 2026.Abstract This study aimed to determine whether sodium nitrite supplementation prevented chronic stress‐induced cerebrovascular dysfunction and cognitive decline. We hypothesize that nitrite supplementation will prevent the oxidative environment and cerebrovascular dysfunction associated with chronic stress and maintain cognitive health.
Emily Burrage +10 more
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Development of Bioaffinity Chromatography for Uricase Purification [PDF]
, 1980 The uricase inhibitors urate, xanthine, oxonate and cyanurate were tried as ligands, for preparing bioaffinity support for chromatographic separation of uricase.
Salleh, Abu Bakar
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Myocardial malondialdehyde and uric acid release after short-lasting coronary occlusion during coronary angioplasty: potential mechanisms for free radical generation [PDF]
, 1991 -
Jong, J.W. (Jan Willem) de +5 more
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Arthritis Care &Research, Volume 78, Issue 2, Page 259-269, February 2026.Objective Although treat‐to‐target urate‐lowering therapy (ULT) is endorsed as best practice in gout management, limited data exist on its impact on health‐related quality of life (HRQoL). We assessed the impact of treat‐to‐target ULT on HRQoL among participants receiving protocolized gout care, identifying factors associated with HRQoL and HRQoL ...
Austin Barry +16 more
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Critical appraisal of the role of pegloticase in the management of gout
Open Access Rheumatology: Research and Reviews, 2012 Hang-Korng Ea,1,2 Pascal Richette1,21Hôpital Lariboisière, Rheumatology Department, Paris, France; 2University of Paris Diderot, Sorbonne Paris Cité, Paris, FranceAbstract: Gout is a debilitating disease secondary to ...
Ea HK, Richette P
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Nitrate Inhibits Nodule Nitrogen Fixation by Accumulating Ureide in Soybean Plants
PlantsThe mechanism by which nitrate inhibits nitrogen fixation in soybean (Glycine max L.) is not fully understood. Accumulation of ureide in soybean plant tissues may regulate the nitrogen fixation capacity through a feedback pathway.
Xuelai Wang +8 more
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Molecular docking analysis of s-triazine derivatives targeting urate oxidase: Implications for antifungal activity against Aspergillus flavus [PDF]
Acta Periodica TechnologicaEstimation of the antifungal activity of compounds is a complex task. Besides experimental analysis, it includes quantitative structure-activity relationship (QSAR) and molecular docking approaches, as in silico methods in the prediction of biological ...
Kovačević Strahinja +3 more
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l-Lactate generates hydrogen peroxide in purified rat liver mitochondria due to the putative l-lactate oxidase localized in the intermembrane space [PDF]
, 1922 In order to ascertain whether and how mitochondria can produce hydrogen peroxide (H2O2) as a result of l-lactate addition, we monitored H2O2 generation in rat liver mitochondria and in submitochondrial fractions free of peroxisomal and cytosolic ...
de Bari, Lidia +3 more
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URATE OXIDASE ENCAPSULATED IN ERYTHROCYTES: 206 [PDF]
Pediatric Research, 1985 Erythrocytes have been proposed as cellular carriers for enzyme replacement therapy. Urate oxidase was encapsulated in erythrocytes using different methods. Average encapsulation was found to be 7 % of the added enzyme activity using a dialysis technique and 1.75 % using a direct hemolysis procedure. Binding of enzyme to the membrane could be excluded.
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