Results 81 to 90 of about 14,896 (211)

Establishment of a novel cynomolgus monkey model of hyperuricemia

Animal Models and Experimental Medicine, Volume 9, Issue 2, Page 354-366, February 2026.
We established a novel hyperuricemia model in cynomolgus monkeys (A) via oral administration of potassium oxonate, hydrochlorothiazide, and adenine mixed in fruits and vegetables. This model (B) targets uric acid synthesis and enzymatic degradation, and (C) regulates renal and intestinal excretion, thereby stably elevating serum uric acid and serving ...
Ji‐Wei Wang, Le Zhang, Can Yang, Guan‐Cong Luo, Rui‐Chang Liu, Yan‐Jun Xu, Sheng Cheng, Wen‐Yu Jiang, Richard Ward, Yang Yang, Cheng Xiang, Shu An, Tian‐Rui Xu   +12 more
wiley   +1 more source

How URAT1 inhibitors can shape the future of chronic gout treatment: a narrative review of uricosurics past and present [PDF]

Exploration of Musculoskeletal Diseases
Gout is a common inflammatory arthritis preceded by chronically elevated levels of serum urate. In addition to leading to gouty flares, hyperuricemia can result in stone-like deposits of monosodium urate crystals (tophi) being deposited in joints and ...
Robert T. Keenan, Zancong Shen, Shunqi Yan, Li-Tain Yeh, Michael H. Pillinger   +4 more
doaj   +1 more source

Serum uric acid as a marker of microvascular damage in systemic sclerosis patients [PDF]

, 2016
Background: Microvascular damage of skin and internal organs is a hallmark of systemic sclerosis (SSc). Serum uric acid (UA) represents a marker of inflammation and endothelial dysfunction.
Amoroso, Antonio, Barbano, Biagio, Barilaro, Giuseppe, Cianci, Rosario, Di Mario, Francesca, Gasperini, Maria Ludovica, Gigante, Antonietta, Quarta, Silvia, Romaniello, Antonella, Rosato, Edoardo   +9 more
core   +1 more source

Spermidine Reproduces the Anti‐Inflammatory Effects of Intermittent Fasting and Prevents Urate and Calcium Pyrophosphate Crystal‐Induced Inflammation

Arthritis &Rheumatology, Volume 78, Issue 2, Page 449-462, February 2026.
Objective Gout caused by the formation of monosodium urate (MSU) crystals and calcium pyrophosphate (CPP) deposition disease are two major types of microcrystalline pathologies in adults. They are responsible for recurrent flares that rely on interleukin (IL) 1β via activation of the NLRP3 inflammasome.
Chinh Nghia Pham, Florence Castelli, Flora Finet, Charles Leroy, Céline Chollet, Twinu W. Chirayath, Subhalaxmi Moitra, Mylène Zarka, Agnès Ostertag, François Brial, Christèle Combes, Augustin Latourte, Thomas Bardin, François Fenaille, Pascal Richette, Hang Korng Ea   +15 more
wiley   +1 more source

A complement to the modern crystallographer's toolbox: Caged gadolinium complexes with versatile binding modes [PDF]

, 2016
A set of seven caged gadolinium complexes were used as vectors for introducing the chelated Gd3+ ion into protein crystals in order to provide strong anomalous scattering for de novo phasing.
Abergel, C., Hermoso, Juan A., Jeudy, S., Kahn, R., Molina, Rafael, Stelter, M.   +5 more
core   +1 more source

Therapeutic Activities and Phytochemical Composition of Helianthus annuus L. Extracts

Chemistry &Biodiversity, Volume 23, Issue 2, February 2026.
ABSTRACT The sunflower (Helianthus annuus L.) is a plant commonly used in agriculture and the fuel industry, as well as being an ornamental garden plant. However, its biologically active compounds make it an interesting plant for medicinal purposes. This review evaluated the phytochemistry of sunflower leaves, stems, receptacles, flowers, seeds, and ...
Marina dos Santos Barreto, Wesley Lisboa de Jesus, Maria Eduarda de Britto Sá, Jessiane Bispo de Souza, Ronaldy Santana Santos, Júlia Santana Lisboa, Pedro Henrique Macedo Moura, Deise Maria Rego Rodrigues Silva, Eloia Emanuelly Dias Silva, Lysandro Pinto Borges, Adriana Gibara Guimarães   +10 more
wiley   +1 more source

Early-onset metabolic syndrome in mice lacking the intestinal uric acid transporter SLC2A9 [PDF]

, 2014
Excess circulating uric acid, a product of hepatic glycolysis and purine metabolism, often accompanies metabolic syndrome. However, whether hyperuricemia contributes to development of metabolic syndrome or is merely a by-product of other processes that ...
DeBosch, Brian J, Fujiwara, Hideji, Kluth, Oliver, Moley, Kelle, Schürmann, Annette   +4 more
core   +2 more sources

Salvia coccinea and Apigenin: A Natural Treasure of Lamiaceae in Pharmacological Innovation

Food Science &Nutrition, Volume 14, Issue 2, February 2026.
Salvia coccinea is rich in bioactive phytochemicals, notably the flavonoid apigenin, offering strong antioxidant, anti‐inflammatory, and antimicrobial effects. By modulating inflammatory and oxidative pathways, it shows potential for managing chronic diseases.
Muhammad Usman Khalid, Muhammad Tauseef Sultan, Muhammad Maaz, Shehnshah Zafar, Anum Shoukat, Nudrat Khursheed, Matteo Bordiga, Amna Junaid   +7 more
wiley   +1 more source

Crucial involvement of xanthine oxidase in the intracellular signalling networks associated with human myeloid cell function [PDF]

, 2014
Xanthine oxidase (XOD) is an enzyme which plays a central role in purine catabolism by converting hypoxanthine into xanthine and then further into uric acid.
Abooali, Maryam, Coughlan, Karen, Gibbs, Bernhard F., Lall, Gurprit S., Lall, Harjinder S., Sumbayev, Vadim V.   +5 more
core   +1 more source

Contribution of a Novel TetR/AcrR Family Transcriptional Regulator RalT of Ralstonia pseudosolanacearum Strain OE1‐1 to the Fine‐Tuning of Its Virulence

MicrobiologyOpen, Volume 15, Issue 1, February 2026.
Predicted regulation of quorum sensing‐, ralfuranone‐, and RalT‐dependent genes (QS/Ral/p0599‐dependent genes) via a novel TetR/AcrR family transcriptional regulator RalT in Ralstonia pseudosolanacearum strain OE1‐1 was shown here. The regulation of ralT is dependent on ralfuranone, and contribution of RalT is popular with the regulation of some quorum
Tatsuya Ueyama, Masayuki Tsuzuki, Sora Tateda, Yuki Terazawa, Aoi Ikeuchi, Akinori Kiba, Kouhei Ohnishi, Yasufumi Hikichi   +7 more
wiley   +1 more source