Results 91 to 100 of about 3,294,575 (284)

Urea Cycle, Properties and Applications of Urea

, 2023
Urea, also known as carbamide, is an organic compound with chemical formula CO(NH2)2. This amide has two amino groups (–NH2) joined by a carbonyl functional group (–C(=O)–).
Kalani, Rekha, Pareek, Chandresh, Tyagi, Renu   +2 more
core   +1 more source

Klotho‐Derived Peptide 1 Protects against Acute Kidney Injury by Directly Targeting Mitochondrial ATAD3A

Advanced Science, EarlyView.
This study uncovers that KP1, a Klotho‐derived peptide, protects the kidney against acute kidney injury, a clinical syndrome with high morbidity and mortality. KP1 enters tubular epithelial cells via endocytosis, directly interacts with the mitochondrial ATAD3A/HIGD2A complex, thereby preventing cytochrome c release, and caspases activation, and ...
Xiaoyao Zhang, Shihui Lin, Tianyu Wu, Zhixin Zhang, Hong Zhou, Xue Hong, Youhua Liu   +6 more
wiley   +1 more source

Use of an oversized AAV8 vector for CPS1 deficiency results in long-term survival and ammonia control

Molecular Therapy: Nucleic Acids
Carbamoyl phosphate synthetase 1 (CPS1) deficiency, a urea-cycle disorder, results in hyperammonemia initiating a sequence of adverse events that can lead to coma and death if not treated rapidly.
Taryn Diep, Wesley Zhou, Rachel E. Reyes, Matthew Nitzahn, Isabel L. Day, Georgios Makris, Lindsay Lueptow, Irina Zhuravka, Stuti Bakshi, Jon Gangoiti, Hyacinth Padaon, Yunfeng Li, Bruce A. Barshop, Johannes Haberle, Gerald S. Lipshutz   +14 more
doaj   +1 more source

Hyperammonemia Encephalopathy due to Urea Cycle Disorder Precipitated by Gastrointestinal Bleed in the Setting of Prior Bariatric Surgery. [PDF]

ACG Case Rep J, 2023
Loeffler J, Elfiky A, Al Moussawi H, Ravindran N.   +3 more
europepmc   +1 more source

Disease‐Stage Synchronized Nanozyme Therapy for Polymicrobial Sepsis through Adaptive Catalytic and Immune Reprogramming

Advanced Science, EarlyView.
A disease‐stage synchronized nanozyme platform is developed to treat polymicrobial sepsis by adapting its functions to changing infection environments. The system eliminates multidrug‐resistant bacteria during early infection while reducing inflammation and restoring immune balance during recovery, providing an integrated strategy for infection control
Anlai Zou, Xiaoxue Zhu, Runhan Zhu, Chengchu Xue, Qinyu Zhang, Mengke Li, Ting Yu, Yuzhen Gao, Zhi Ruan, Ying Fu, Yunlei Xianyu, Jun Zhang   +11 more
wiley   +1 more source

Late onset arginase deficiency presenting with encephalopathy and midbrain hyperintensity

Annals of Indian Academy of Neurology, 2016
Urea cycle disorders (UCD) are very rare metabolic disorders that present with encephalopathy and hyperammonemia. Of the UCDs, Arginase deficiency (ARD) is the rarest and presents in childhood with a progressive spastic diplegia or seizures.
Boby Varkey Maramattom, Rajat Raja, Anuroop Balagopal   +2 more
doaj   +1 more source

Fatal Encephalopathy Caused by a Urea Cycle Disorder. [PDF]

J Clin Neurol, 2021
Park SH, Lee JH, Choi SJ, Kim HS, Kim NH.   +4 more
europepmc   +1 more source

Blood metabolomics analysis identifies abnormalities in the citric acid cycle, urea cycle, and amino acid metabolism in bipolar disorder

, 2016
BackgroundBipolar disorder (BD) is a severe and debilitating psychiatric disorder. However, the precise biological basis remains unknown, hampering the search for novel biomarkers.
Pålsson, Erik, Sellgren, Carl M., Jakobsson, Joel,, Yoshimi, Noriko, Futamura, Takashi, Holmén-Larsson, Jessica, Jakobsson, Joel, Salehi, Alireza M, Holmén Larsson, Jessica,, Landén, Mikael,, Salehi, Alireza M., Hashimoto, Kenji, Landén, Mikael, Kakumoto, Keiji, Sellgren, Carl M, Pålsson, Erik,, Yoshimi, N, Futamura, T, Landen, M, Jakobssong, J, Palssong, E, Kakumoto, K, Sellgren, CM, Salehi, AM, Holmen-Larsson, J, Hashimoto, K   +25 more
core   +1 more source

Gut Microbiota‐Isoallolithocholic Acid Crosstalk Promotes Calcium Oxalate Kidney Stone Formation via PARP1‐Mediated Parthanatos

Advanced Science, EarlyView.
ABSTRACT Bile acids have been implicated in calcium oxalate (CaOx) nephrolithiasis. Here, we employ multi‐omics approaches to identify isoallolithocholic acid (isoalloLCA) as the key bile acid elevated in the feces, serum, kidney, and urine of CaOx rats, confirmed by spatial metabolomics.
Zijian Zhou, Ruixi Yu, Xuan Zhou, Feng Shi, Zeyu Lin, Peng Gao, Lujia Wang, Ninghan Feng, Zhong Wu, Dawei Wang   +9 more
wiley   +1 more source

Treatment and management for children with urea cycle disorder in chronic stage. [PDF]

Zhejiang Da Xue Xue Bao Yi Xue Ban, 2023
Huang X.
europepmc   +1 more source