A New Urease Inhibitor from Viola betonicifolia [PDF]
Molecules, 2014 Urease has attracted much attention, as it is directly involved in the formation of infection stones and contributes to the pathogenesis of urolithiasis, pyelonephritis, ammonia and hepatic encephalopathy, hepatic coma and urinary catheter encrustation ...
Naveed Muhammad +6 more
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Recent advances in design of new urease inhibitors: A review
Journal of Advanced Research, 2018 Urease is a nickel-dependent metalloenzyme found in plants, some bacteria, and fungi. Bacterial enzyme is of special importance since it has been demonstrated as a potent virulence factor for some species.
Paweł Kafarski, Michał Talma
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Metallochaperone UreG serves as a new target for design of urease inhibitor: A novel strategy for development of antimicrobials. [PDF]
PLoS Biology, 2018 Urease as a potential target of antimicrobial drugs has received considerable attention given its versatile roles in microbial infection. Development of effective urease inhibitors, however, is a significant challenge due to the deeply buried active site
Xinming Yang +7 more
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Agriculture, 2022 Urea granule dissolution in soil and soil urease activity are essential parameters for the accurate prediction of nitrogen dynamics after urea application, but both are scarcely studied. The response of urease activity to temperature is unclear under the
Kang Ni, Andreas Siegfried Pacholski
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In-situ preparation of a urea-based product with urease-inhibiting properties from industrial integrated humic acid-enhanced urea production: A comparative study on the key role of functional group structures [PDF]
Industrial Crops and ProductsAmmonia (NH3) volatilization from urea fertilization causes substantial nitrogen (N) loss and environmental pollution risks. Humic acid-enhanced urea (HAU), produced by directly incorporating low-cost humic acid (HA) into molten urea during the ...
Yingqiang Zhang +8 more
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Luteolin as a urease inhibitor: A novel therapeutic strategy against <i>Helicobacter pylori</i>. [PDF]
VirulenceWang X +8 more
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Provenance-Associated Confounding in Cross-Collection Comparisons of Urease Inhibitors: A Quantified Reference Scale and a Domain-Aware Alternative. [PDF]
Int J Mol SciFarías-Abarca J +8 more
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Biological Evaluation and Molecular Docking of Protocatechuic Acid from Hibiscus sabdariffa L. as a Potent Urease Inhibitor by an ESI-MS Based Method [PDF]
Molecules, 2017 Studies on enzyme inhibition remain a crucial area in drug discovery since these studies have led to the discoveries of new lead compounds useful in the treatment of several diseases.
Sherif T. S. Hassan, Emil Švajdlenka
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Urease inhibitors: current advances, therapeutic potentials, and clinical challenges. [PDF]
Future Med ChemAlzoubi OH +12 more
europepmc +5 more sources
Novel Inhibitors Targeting Urease Promote Fungicidal and Antivirulence Effects in <i>Cryptococcus</i>. [PDF]
ACS OmegaBarreto TL +11 more
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