Results 161 to 170 of about 30,710 (255)

Disulfiram Attenuates Adenine‐Induced Renal Fibrosis by Modulating Inflammatory and Immunometabolic Responses

The FASEB Journal, Volume 40, Issue 18, 30 September 2026.
Chronic kidney disease (CKD) is characterized by persistent inflammation that drives progressive renal injury and fibrosis. In this study, we demonstrate that disulfiram markedly attenuates kidney injury and fibrosis in adenine‐induced nephropathy by suppressing innate immune responses and reducing DNA damage and cellular senescence.
Saori Kin, Yuji Oe, Shun Ishigaki, Ichiro Fujio, Mariko Miyazaki, Tetsuhiro Tanaka   +5 more
wiley   +1 more source

Hyperkisspeptinemia and hypothalamic-pituitary-gonadal axis uncoupling in hemodialysis patients: clinical evidence suggestive of central desensitization. [PDF]

Clin Kidney J
Lan N, Ye D, Li M, Zeng F, Xue C, Chen Z, Shao Q, Liu J, Liu N, Yang B.   +9 more
europepmc   +1 more source

Establishing an assay to evaluate d‐amino acid oxidase enzyme kinetics and inhibition using WST‐8 redox dye

FEBS Open Bio, Volume 16, Issue 9, Page 1645-1656, September 2026.
This study investigated a novel WST‐8‐based assay for evaluating d‐Amino acid oxidase (DAO) inhibitors. We confirmed its effectiveness using known inhibitors and found that uremic toxins possess relatively weak inhibitory activity compared to existing drugs.
Kahoko Miyake, Yuki Enoki, Yuka Nakazawa, Kazuaki Taguchi, Kazuaki Matsumoto   +4 more
wiley   +1 more source

From particle count to residence time: a kinetic framework for atherogenic risk. [PDF]

Front Cardiovasc Med
Larronde E.
europepmc   +1 more source

Transcriptional risk score for chronic kidney disease: relation to Alzheimer's disease

Alzheimer's &Dementia, Volume 22, Issue 9, September 2026.
Abstract INTRODUCTION Although Alzheimer's disease (AD) is prevalent in individuals with chronic kidney disease (CKD), the mechanistic link remains unclear. We assessed the impact of CKD transcriptional risk on AD endophenotypes. METHODS We calculated the CKD transcriptional risk score (CKD‐TRS) using blood transcriptomes from the Alzheimer's Disease ...
Jung‐Min Pyun, Young Ho Park, Jiyun Hwang, SangYun Kim, Yongjin Yi, Kwangsik Nho, for the Alzheimer's Disease Neuroimaging Initiative   +6 more
wiley   +1 more source

Immune Microenvironment and Genetic Signatures of End-Stage Renal Disease and Their Association with Sepsis: Insights from Public Transcriptomic Data and a Multicenter Clinical Cohort. [PDF]

Biomedicines
Wang SH, Yang KY, Sheu CC, Wu BR, Chan MC, Feng JY, Chen CM, Shen YC, Huang WH, Peng CK, Huang SM.   +10 more
europepmc   +1 more source

Kidney function and brain health: cognitive and structural signatures across cohorts

Alzheimer's &Dementia, Volume 22, Issue 9, September 2026.
Abstract INTRODUCTION Chronic kidney disease (CKD) is linked to cognitive decline, yet the roles of estimated glomerular filtration rate (eGFR) and its variability remain unclear. METHODS We analyzed 6847 adults from two population‐based cohorts (the Multimodality MEdical imaging sTudy bAsed on KaiLuan Study [META‐KLS], UK Biobank) and 426 CKD patients
Min Li, Wenbo Yang, Ying Hui, Huijing Shi, Yuntao Wu, Li Yu, Lijun Song, Yanfang Tan, Xintian Ren, Xiaoyan Bai, Xiaoshuai Li, Zhenghan Yang, Weikang Guo, Shouling Wu, Jing Li, Zhenchang Wang, Han Lv, Hao Wang   +17 more
wiley   +1 more source

The quality and reliability of short videos about uremia on Bilibili and TikTok in China: A cross sectional study. [PDF]

Medicine (Baltimore)
Hang YY, Hsu HQ, Lu M, Bai L, Qian J.
europepmc   +1 more source

Hippocampal Volume Mediates the Association Between Serum Ferritin and Cognition in Non‐Dialysis End‐Stage Renal Disease Patients

Brain and Behavior, Volume 16, Issue 9, September 2026.
Cognitive impairment is a prevalent neurological complication of end‐stage renal disease (ESRD), yet the neuroanatomical pathway linking iron overload to cognitive decline remains unclear. This study enrolled 50 nondialysis ESRD patients and 48 demographically matched healthy controls, all of whom underwent 3.0T structural MRI for voxel‐based ...
Jingjing Si, Minghua Zhu, Mingzhe Dai
wiley   +1 more source

Declining eGFR and Uremia Are Associated with Remnant Cholesterol Accumulation and Reduced HDL-C in Non-Dialysis Chronic Kidney Disease. [PDF]

J Clin Med
Alyami H, Alshuweishi FA, Baghdadi NA, Al-Sharafa MM, Jaber Alqahtani A, Alshuweishi Y.   +5 more
europepmc   +1 more source