Results 51 to 60 of about 4,915 (262)

Unique circulating miRNAome signatures captured with distinct molecular states in Lynch syndrome and sporadic colorectal cancer

Molecular Oncology, EarlyView.
Circulating microRNA profiles distinguish nonmalignant Lynch syndrome from cancer‐associated Lynch syndrome, sporadic colorectal cancer, and healthy controls. Age‐stratified analysis reveals disease‐specific regulatory states, and a six‐miRNA panel shows concordant separation in an independent colorectal tissue cohort.
Ramadhani Salum Chambuso, Md Shohel Ul Islam, Rosa M Xicola, Raj Ramesar, Xavier Llor, Sinclair Steele   +5 more
wiley   +1 more source

Impact des déterminants socio-territoriaux sur le recours aux services d’urgences en Normandie

Revue Francophone sur la Santé et les Territoires
Depuis les années 1990, une augmentation des recours aux urgences est observée en France. Afin de réduire ces recours et éviter une surcharge des services d’urgences, diverses actions ont été mises en place par les pouvoirs publics (continuité des soins ...
Valentin Courtillet, Mélanie Martel
doaj   +1 more source

Le n'ud ileosigmoidien: ' propos de 2 cas

The Pan African Medical Journal, 2012
Le n'ud iléosigmoïdien ou l'ileosigmoid knot (ISK), est une entité clinique exceptionnelle, c'est une urgence chirurgicale caractérisée par une strangulation du grêle en formant un n'ud autour de la base du colon sigmoïde avec risque de nécrose rapide du
Fatimazahra Bensardi, Khalid Elhattabi, Abdelaziz Fadil, Nadia Benissa, Rachid Lefriyekh, Driss Khaiz1, Saad Berrada, Ouariti Najib Zerouali   +6 more
doaj   +1 more source

Evaluation of a short formation on the performance of point-of-care renal ultrasound performed by physicians without previous ultrasound skills: prospective observational study

Critical Ultrasound Journal, 2017
Background Point-of-Care Ultrasound (PoCUS) is recommended by emergency medicine societies for the detection of hydronephrosis. Training of certified Emergency Physicians (EP) without prior ultrasound experience remains debated.
François Javaudin, François Mounier, Philippe Pes, Idriss Arnaudet, Frédéric Vignaud, Eric Frampas, Philippe Le Conte, Winfocus-France study group   +7 more
doaj   +1 more source

Urgence climatique, urgence sociale

Calenda, 2022
Pour son numéro du dernier trimestre 2022, la revue s’attachera à interroger la manière dont le travail social peut s’inscrire dans les logiques de développement durable, i.e. une conception du développement qui intègre, sur le long terme, des objectifs écologiques et sociaux aux objectifs strictement économiques.
openaire   +1 more source

Targeting the EpCAM‐AXL axis to overcome drug resistance in lung cancer

Molecular Oncology, EarlyView.
Lung cancer cells often evade therapy by hijacking signaling pathways. We reveal that cleaved EpCAM (sEpCAM) stabilizes the oncogenic protein AXL, driving NF‐κB and STAT3‐mediated chemoresistance. This EpCAM‐AXL axis identifies a high‐risk patient subset with poor prognosis.
Alexa Guerrero‐Alba, Mark Shacker, Timothy P. Fleming, Michael A. Smith, Ross M. Bremner, Narendra V. Sankpal   +5 more
wiley   +1 more source

Decompressive craniotomy in the management of malignant cerebral venous thrombo- sis: A case report

Journal de la Faculté de Médecine d'Oran, 2022
Introduction - Cerebral venous thrombosis is a condition that usually affects young woman. It exposes to intracranial hypertension, which in rare cases entails a commitment that compromises the vital prognosis.
Soumia Benbernou, Abdelmoumene Ryad Ayoun, Houria Mokhtari Djebli, Maamer Bouchakour, Batoul Chalabi, Nabil Ghomari, Khalida Bouyacoub, Abdelkader Azza, Malik Sofiane Iles, Manel Aich   +9 more
doaj  

Malformin A1–mediated cytotoxicity in ovarian cancer cells occurs through pyroptosis and autophagy

FEBS Open Bio, EarlyView.
This study investigated the effects of the natural compound Malformin A1 (MA1) on the cytoskeleton that regulates cell proliferation and migration. Disruption of the cytoskeleton can impair these processes and promote cancer cell death. MA1 disrupted cytoskeletal organization, induced DNA damage, inflammation, activated autophagy, and pyroptosis ...
Nada Abdullah Hassan, Ikram A. Burney, Shika Hanif Malgundkar, Siva Ramamoorthy, Ressin Varghese, Mohamed A. Al‐Kindi, Hamad Al Riyami, Shadia Al Bahlani, Sergey Dobretsov, Syed Imran Hassan, Benjamin K. Tsang, Yahya Tamimi   +11 more
wiley   +1 more source

From patient advocacy to patient‐driven research: Building active partnerships beginning at the bench to reach the bedside

FEBS Open Bio, EarlyView.
Research is strongest when conducted alongside patients, not just about them. Patient research organizations help integrate patient perspectives into research priorities, study design, and scientific meetings, leading to meaningful patient outcomes and development of relevant therapies.
Jenica H. Kakadia, Rachel Heilmann, Maximiliano Barrientos, Laura MacNeill, Ingrid Vallee, Sarah K. Schultz, Patrick O'Donoghue, Angelica A. Moresco, Victoria M. Siu, Ilka U. Heinemann   +9 more
wiley   +1 more source

The C‐terminal truncated splicing variant of NK1R negatively modulates substance P‐stimulated NK1R signaling

FEBS Open Bio, EarlyView.
The neurokinin 1 receptor exists as full‐length (NK1L) and C‐terminally truncated (NK1S) splice variants. We show that NK1S heterodimerizes with NK1L, impairing Gαq coupling and Ca2+ mobilization while enhancing β‐arrestin1 recruitment. NK1S suppresses substance P‐driven gene expression and cell migration, revealing NK1S as an endogenous biased ...
Lan Phuong Nguyen, Duc Trung Nguyen, Minyoung Cho, Jihun Kim, Soyeon In, Thai Uy Nguyen, Sunghoon Hurh, Beom Jin Park, Jong‐Ik Hwang   +8 more
wiley   +1 more source