Results 51 to 60 of about 4,797 (259)

Corps étranger intra-rectal: médecine traditionnelle ou trouble de comportement?

open access: yesThe Pan African Medical Journal, 2014
L'insertion de corps étranger (CE) par l'anus est devenue un motif assez fréquent de consultation aux urgences. Cette introduction du CE est rarement accidentelle et se voit surtout dans le cadre d'actes sexuels et/ou parfois criminels survenant sur un ...
Pierlesky Elion Ossibi, Khalid Mazaz
doaj   +1 more source

Acute fissuration of a giant splenic artery aneurysm detected by point-of-care ultrasound: case report

open access: yesCritical Ultrasound Journal, 2018
Background Epigastric pain is frequent in Emergency Medicine and remains a challenging situation. Besides benign etiologies such as gastritis or uncomplicated cholelithiasis, it could reveal myocardial infarction or vascular disease.
Philippe Le Conte   +5 more
doaj   +1 more source

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

open access: yesFEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa   +2 more
wiley   +1 more source

Profils épidémiologiques des acidocétoses diabètiques aux urgences

open access: yesThe Pan African Medical Journal, 2019
INTRODUCTION : l'acidocétose diabétique (ACD) est une complication métabolique grave du diabète. Son incidence est en augmentation ces dernières années, cependant sa mortalité reste faible.
Sarra Jouini   +6 more
doaj   +1 more source

Structural insights and therapeutic targets in Acinetobacter baumannii capsule biosynthesis

open access: yesFEBS Letters, EarlyView.
Hypervirulent KL49 A. baumannii's capsular polysaccharide contains the nonulosonic acid 8‐epi‐Leg5,7Ac2, synthesized by epimerization via ElaA, ElaB, and ElaC. Crystal structures of ElaA, ElaB, and ElaC reveal their role in CMP‐Leg5,7Ac2 synthesis and regioselective C8 epimerization.
Woo Cheol Lee   +7 more
wiley   +1 more source

Profil de consommation des médicaments au service des urgences de l’Institut de Cardiologie d’Abidjan – Côte d’ivoire

open access: yesJournal Africain de Technologie Pharmaceutique et Biopharmacie
La disponibilité des médicaments pour les urgences cardiovasculaires permet une prise en charge adéquate des patients. Cette étude avait pour objectif d’évaluer le profil de consommation des médicaments au service des urgences de l’Institut de ...
Gbongue Eric Tia   +8 more
doaj   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

open access: yesMolecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric   +10 more
wiley   +1 more source

Decompressive craniotomy in the management of malignant cerebral venous thrombo- sis: A case report

open access: yesJournal de la Faculté de Médecine d'Oran, 2022
Introduction - Cerebral venous thrombosis is a condition that usually affects young woman. It exposes to intracranial hypertension, which in rare cases entails a commitment that compromises the vital prognosis.
Soumia Benbernou   +9 more
doaj  

Differential expression of cancer‐related genes supports prediction of poor response to first‐line treatments in T‐ALL pediatric patients with high minimal residual disease

open access: yesMolecular Oncology, EarlyView.
In the present work, we have identified a transcriptional signature based on the differential expression of six genes (BCL2&MAST4, HSH2D&LAT2, METRN&PITPNM2) that would facilitate the early detection of T‐cell acute lymphoblastic leukemia (T‐ALL) patients prone to a poor treatment response and could be implemented at diagnosis, along with other risk ...
Antonio Lahera   +11 more
wiley   +1 more source

Longitudinal genome‐wide aneuploidy measurements in circulating cell‐free DNA to predict lack of benefit from pembrolizumab in patients with metastatic urothelial cancer

open access: yesMolecular Oncology, EarlyView.
Many patients with urothelial cancer do not benefit from treatment with pembrolizumab, while at risk of severe side effects. Changes in the levels of circulating tumor DNA early during treatment, measured by a simple and affordable assay that can be easily implemented in the clinic, can be used as a prognostic tool to identify these patients.
Youssra Salhi   +14 more
wiley   +1 more source

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