Results 71 to 80 of about 14,438 (295)

Longitudinal genome‐wide aneuploidy measurements in circulating cell‐free DNA to predict lack of benefit from pembrolizumab in patients with metastatic urothelial cancer

Molecular Oncology, EarlyView.
Many patients with urothelial cancer do not benefit from treatment with pembrolizumab, while at risk of severe side effects. Changes in the levels of circulating tumor DNA early during treatment, measured by a simple and affordable assay that can be easily implemented in the clinic, can be used as a prognostic tool to identify these patients.
Youssra Salhi, Stavros Makrodimitris, Sandra van Wilpe, Iris te Paske, Vanja de Weerd, Corine M. Beaufort, Hans M. Westgeest, Jens Voortman, Maureen J. B. Aarts, Maud Rijnders, Astrid A. M. van der Veldt, Ronald de Wit, Niven Mehra, Saskia M. Wilting, Debbie G. J. Robbrecht   +14 more
wiley   +1 more source

Evaluation of a short formation on the performance of point-of-care renal ultrasound performed by physicians without previous ultrasound skills: prospective observational study

Critical Ultrasound Journal, 2017
Background Point-of-Care Ultrasound (PoCUS) is recommended by emergency medicine societies for the detection of hydronephrosis. Training of certified Emergency Physicians (EP) without prior ultrasound experience remains debated.
François Javaudin, François Mounier, Philippe Pes, Idriss Arnaudet, Frédéric Vignaud, Eric Frampas, Philippe Le Conte, Winfocus-France study group   +7 more
doaj   +1 more source

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

Profil de consommation des médicaments au service des urgences de l’Institut de Cardiologie d’Abidjan – Côte d’ivoire

Journal Africain de Technologie Pharmaceutique et Biopharmacie
La disponibilité des médicaments pour les urgences cardiovasculaires permet une prise en charge adéquate des patients. Cette étude avait pour objectif d’évaluer le profil de consommation des médicaments au service des urgences de l’Institut de ...
Gbongue Eric Tia, Kouakou Etienne Effo, Gniènèfèrètien Nounaféri Awa SILUE , Konan Hamed KOUAKOU , Ahou Axelle Edith KOUADIO , Moulad Ephraïm ALLIMAN , Amankou Donaldo Jean-Fabius AHUA , Geneviève N’GUESSAN-IRIE , N’doua Gisèle KOUAKOU-SIRANSY   +8 more
doaj   +1 more source

Le n'ud ileosigmoidien: ' propos de 2 cas

The Pan African Medical Journal, 2012
Le n'ud iléosigmoïdien ou l'ileosigmoid knot (ISK), est une entité clinique exceptionnelle, c'est une urgence chirurgicale caractérisée par une strangulation du grêle en formant un n'ud autour de la base du colon sigmoïde avec risque de nécrose rapide du
Fatimazahra Bensardi, Khalid Elhattabi, Abdelaziz Fadil, Nadia Benissa, Rachid Lefriyekh, Driss Khaiz1, Saad Berrada, Ouariti Najib Zerouali   +6 more
doaj   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

Les signes oculaires des urgences neurologiques

, 2009
Les urgences neurologiques en ophtalmologie sont caractérisées par trois symptômes principaux isolés ou associés :la douleur, la diplopie, et la diminution rapide de l'acuité visuelle.Il y a 4 réelles urgences neuro-ophtalmologiques dont 2 urgences ...
Cordonnier, Monique
core  

ZW4864‐mediated inhibition of the β‐catenin/BCL9/BCL9L complex reveals therapeutic potential in bladder cancer

Molecular Oncology, EarlyView.
BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi, Mandy Berndt‐Paetz, Eileen Lerner, Gregoire Najjar, Anca Azoitei, Krishna Pal Singh, Shailendra Kumar Gupta, Olaf Wolkenhauer, Cagatay Günes, Otmar Huber, Marc‐Oliver Grimm, Daniel Steinbach   +11 more
wiley   +1 more source

Urgences abdominales chirurgicales au Centre de Santé de Référence de Bougouni

, 2015
Il s'agissait d'une étude prospective réalisée au CS Réf de Bougouni du 1er Novembre 2013 au 30 Octobre 2014.Au cours de l'étude nous avons recensé 95 cas d'urgences abdominales chirurgicales dont 56 hommes et 39 Femmes avec un sexe ratio de 1,43 en ...
Diabaté, Sidi
core  

Mycobacterial cell division arrest and smooth‐to‐rough envelope transition using CRISPRi‐mediated genetic repression systems

FEBS Open Bio, EarlyView.
CRISPRI‐mediated gene silencing and phenotypic exploration in nontuberculous mycobacteria. In this Research Protocol, we describe approaches to control, monitor, and quantitatively assess CRISPRI‐mediated gene silencing in M. smegmatis and M. abscessus model organisms.
Vanessa Point, Wafaa Achache, Janïs Laudouze, Eliana Sepulveda Ramos, Mickaël Maziero, Céline Crauste, Stéphane Canaan, Pierre Santucci   +7 more
wiley   +1 more source