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[Uricosuric agents: Should they be used in asymptomatic hyperuricemia?].

Tidsskrift for den Norske laegeforening : tidsskrift for praktisk medicin, ny raekke, 1976
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Uricosuric Agents and Phenolsulfonphthalein Excretion

Archives of Internal Medicine, 1963
Introduction At the time of his historic discovery of hyperuricemia in gout, A. B. Garrod stated that "Gout would thus appear, at least partly, to depend on a loss of power (temporary or permanent) in the uric acid-excreting function of the kidneys."1Thus began a century of interest and controversy over the role of the kidney in the pathogenesis of ...
D S, NEWCOMBE, A S, COHEN
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Zoxazolamine — A Potent Uricosuric Agent

New England Journal of Medicine, 1958
ZOXAZOLAMINE¶ has been widely used during the past two years for the purpose of decreasing spasm of skeletal muscle, presumably via a depressant effect upon polysynaptic pathways in the central nervous system. Occasional side effects, such as drowsiness, lightheadedness, dizziness, abdominal discomfort, vomiting, headache and transient blotching of the
E B, Reed, T V, Feichtmeir, F M, Willett
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Uricosuric Effect of an Anticholinergic Agent in Hyperuricemic Subjects

Archives of Internal Medicine, 1974
An anticholinergic agent, glycopyrrolate, produced an increase in the fractional excretion of uric acid of greater than 20% in eight of 19 subjects with hyperuricemia or gout but in none of the 15 normouricemic control subjects. Glycopyrrolate placebo had no effect.
A E, Postlethwaite, C M, Ramsdell, W N, Kelley   +2 more
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Benzbromarone as a Long-Term Uricosuric Agent

1980
Benzbromarone is a potent uricosuric drug with a rapid onset and relatively long duration of action. It belongs to a new class of antihyperuricemic compounds and has the following structural formula and name: Open image in new window 3- (3,5-dibromo-4-hydroxybenzoyl) — 2 ...
R, Bluestone, J, Klinenberg, I K, Lee
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Uricosuric Action of Cholecystographic Agents

New England Journal of Medicine, 1971
Abstract The oral cholecystographic agents are highly lipid-soluble carboxylic acids. In this respect they resemble probenecid and some other uricosuric agents. Because of continuing case reports of nephrotoxicity of the gallbladder dyes, the possibility was raised that they have a uricosuric action. Ratios of uric acid to creatinine were determined in
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Reversal of Thiazide-Induced Transient Hyperuricemia by Uricosuric Agents

New England Journal of Medicine, 1962
SINCE their introduction in 1958 the thiazides have had very extensive use in medical practice. Coincident with their wide acceptance, reports began to appear concerning side effects such as hypokalemia,1 2 3 hyperglycemia4 and hyperuricemia.3 , 5 6 7 8 9 10 11 Healey and his associates7 have demonstrated that uricosuric agents can prevent such ...
R P, SMILO, W R, BEISEL, P H, FORSHAM
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Mobilization of gouty tophi by protracted use of uricosuric agents

The American Journal of Medicine, 1951
Abstract A case of advanced tophaceous gout exhibiting unequivocal reduction in size of many tophi in the course of protracted uricosuric therapy is described. It may be possible by proper use of uricosuric agents not only to minimize new tophus formation but also to cause the disappearance of old established tophi.
T F, YU, A B, GUTMAN
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Probenecid Act as an Uricosuric agent: A Review

Asian Journal of Research in Pharmaceutical Science, 2018
Probenecid is s prototypical uricosuric agent which is predominantly used to inhibit the renal excretion of organic anions and reduces tubular reabsorption of urate. Probenecid has also been used to treat patients with renal impairment, and, because it reduces the renal tubular excretion of other drugs, has been used as an adjunct to antibacterial ...
Mayur S. Jain, Shashikant D. Barhate, Bhushan P. Gayakwad   +2 more
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[Uricosuric agent].

Nihon rinsho. Japanese journal of clinical medicine, 2008
Urate lowering treatment is indicated in patients with recurrent acute attacks, tophi, gouty arthropathy, radiographic changes of gout, multiple joint involvement, or associated uric acid nephrolithiasis. Uricosuric agents like benzbromarone and probenecid are very useful to treat hyperuricemia as well as allopurinol (xanthine oxidase inhibitor ...
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