Evaluation of the Safety and Pharmacokinetics of Single‐Dose Oral Probenecid Administration in Healthy Dogs [PDF]
Journal of Veterinary Internal MedicineBackground Grape‐induced acute kidney injury (AKI) is caused by tartaric acid and may lead to death in dogs. Probenecid, an organic anion transporter‐1 inhibitor, recently has been shown to block the uptake of tartaric acid in Madin–Darby canine kidney ...
Margaret Cook +4 more
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JACC: Case Reports, 2019 A 56-year-old man with multiple cardiac manifestations of type 1 myotonic dystrophy, including severe, nonischemic cardiomyopathy, presented in refractory cardiogenic shock requiring inotropic therapy.
Evan C. Klein, MD +2 more
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Pharmacological mechanisms of probenecid for SARS-CoV-2 and RSV co-infection: findings of system pharmacology, molecular docking, molecular dynamics simulation, and structure–activity relationship [PDF]
Frontiers in MicrobiologyBackgroundThe clinical consequences of the co-infection with novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and respiratory syncytial virus (RSV) are not optimistic.
Junbin Hong +7 more
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Effects of Acute Probenecid Administration on Histopathological and Functional Outcomes after Spinal Cord Injury in Rats [PDF]
Neurotrauma ReportsSpinal cord injury (SCI) triggers an inflammatory response that is partially mediated by the inflammasome and the production of pro-inflammatory cytokines.
Toru Asari +7 more
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Multitargeting Pt(IV) Anticancer Prodrugs Bearing Mono- and Bis-Probenecid Ligands in Axial Positions: Synthesis and Evaluation of Biological Activity [PDF]
PharmaceuticalsBackground: To battle the side effects of anticancer Pt(II) drug cisplatin, the development of photoactivatable and/or intracellular reduction-activatable Pt(IV) prodrugs has become a promising strategy. Methods: Herein, two novel Pt(IV) prodrugs, namely,
Panxing Qiu +7 more
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Evaluation of Probenecid Against Filovirus Replication in Vero E6 Cells [PDF]
VirusesIn human and non-human primates, filoviruses, e.g., Ebolaviruses, cause severe hemorrhagic fever for which there are few therapeutic options. While there are licensed vaccines and therapeutics for Ebola virus disease, there is no approved vaccine or ...
Kendra Alfson +4 more
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Probenecid Treatment Inhibits Replication of the Edmonston Measles Virus Strain in Vero Cells [PDF]
VirusesThere are no FDA-approved antiviral treatments for measles virus (MeV). Management is mainly supportive care. MeV treatments may include vitamin A, ribavirin, the MeV vaccine, or human immunoglobulin for pregnant patients exposed to MeV but lacking ...
Jackelyn Murray +2 more
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Probenecid Inhibits NLRP3 Inflammasome Activity and Mitogen-Activated Protein Kinases (MAPKs) [PDF]
BiomoleculesProbenecid has long been a versatile drug in pharmacological therapies, primarily known for blocking active tubular secretion in the kidney, affecting both endogenous substances like uric acid and exogenous ones like penicillin.
Les P. Jones +4 more
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Journal of the American Heart Association, 2018 Background Transient receptor potential vanilloid 2 is a calcium channel activated by probenecid. Probenecid is a Food and Drug Administration–approved uricosuric drug that has recently been shown to induce positive lusitropic and inotropic effects in ...
Nathan Robbins +2 more
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Evidentiary Standards for Newly Approved Antibiotics for Uncomplicated Urinary Tract Infections [PDF]
AntibioticsImportance: Uncomplicated urinary tract infections (uUTIs) are among the most common bacterial infections and are typically treated with existing oral antibiotics.
Rosa Rodriguez-Monguio +2 more
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