Results 1 to 10 of about 10,888 (147)

Evaluation of the Safety and Pharmacokinetics of Single‐Dose Oral Probenecid Administration in Healthy Dogs [PDF]

Journal of Veterinary Internal Medicine
Background Grape‐induced acute kidney injury (AKI) is caused by tartaric acid and may lead to death in dogs. Probenecid, an organic anion transporter‐1 inhibitor, recently has been shown to block the uptake of tartaric acid in Madin–Darby canine kidney ...
Margaret Cook, Daniel L. Gustafson, Katie Kroeker, Sarah Shropshire, Kristin M. Zersen   +4 more
doaj   +2 more sources

Probenecid Improves Cardiac Function in Patients With Heart Failure With Reduced Ejection Fraction In Vivo and Cardiomyocyte Calcium Sensitivity In Vitro

Journal of the American Heart Association, 2018
Background Transient receptor potential vanilloid 2 is a calcium channel activated by probenecid. Probenecid is a Food and Drug Administration–approved uricosuric drug that has recently been shown to induce positive lusitropic and inotropic effects in ...
Mohit Kumar, Mohamed Effat, Sheryl Koch   +2 more
exaly   +3 more sources

Probenecid

JACC: Case Reports, 2019
A 56-year-old man with multiple cardiac manifestations of type 1 myotonic dystrophy, including severe, nonischemic cardiomyopathy, presented in refractory cardiogenic shock requiring inotropic therapy.
Evan C. Klein, MD, Jack Rubinstein, MD, Jennifer L. Strande, MD, PhD   +2 more
doaj   +2 more sources

Pharmacological mechanisms of probenecid for SARS-CoV-2 and RSV co-infection: findings of system pharmacology, molecular docking, molecular dynamics simulation, and structure–activity relationship [PDF]

Frontiers in Microbiology
BackgroundThe clinical consequences of the co-infection with novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and respiratory syncytial virus (RSV) are not optimistic.
Junbin Hong, Zhendong Guo, XiaoMei Huang, Peng Wu, Xinying Chen, Xiaoyi Liu, Jinghua Yang, Yanni Lai   +7 more
doaj   +2 more sources

Effects of Acute Probenecid Administration on Histopathological and Functional Outcomes after Spinal Cord Injury in Rats [PDF]

Neurotrauma Reports
Spinal cord injury (SCI) triggers an inflammatory response that is partially mediated by the inflammasome and the production of pro-inflammatory cytokines.
Toru Asari, Sunao Tanaka, Damien D. Pearse, Juan Pablo de Rivero Vaccari, Toshitada Sawada, Yasuyuki Ishibashi, Robert W. Keane, W. Dalton Dietrich   +7 more
doaj   +2 more sources

Probenecid Treatment Inhibits Replication of the Edmonston Measles Virus Strain in Vero Cells [PDF]

Viruses
There are no FDA-approved antiviral treatments for measles virus (MeV). Management is mainly supportive care. MeV treatments may include vitamin A, ribavirin, the MeV vaccine, or human immunoglobulin for pregnant patients exposed to MeV but lacking ...
Jackelyn Murray, David E. Martin, Ralph A. Tripp   +2 more
doaj   +2 more sources

Preclinical Evaluation of 5F-αMe-3BPA for Improving Pharmacokinetics in Boron Neutron Capture Therapy [PDF]

Pharmaceutics
Background/Objectives: Boron neutron capture therapy (BNCT) relies on the selective delivery of boron-10 to tumor cells. Although 4-[10B]borono-L-phenylalanine (BPA) is currently the only clinically approved BNCT agent, it is limited by poor L-type amino
Naoya Kondo, Fuko Hirano, Saki Iritani, Kensuke Suzuki, Anna Miyazaki, Takashi Temma   +5 more
doaj   +2 more sources

PROBENECID AND ZIDOVUDINE METABOLISM

Lancet, The, 1989
The effects of probenecid, a known inhibitor of glucuronidation, on the pharmacokinetics of zidovudine were assessed in eight subjects receiving zidovudine as treatment for human immunodeficiency virus infection. Zidovudine plasma concentrations were measured while subjects were receiving zidovudine alone, after 3 days of zidovudine plus 500 mg ...
Craig W Hendrix, P S Lietman, J G Bartlett   +2 more
exaly   +3 more sources

Multitargeting Pt(IV) Anticancer Prodrugs Bearing Mono- and Bis-Probenecid Ligands in Axial Positions: Synthesis and Evaluation of Biological Activity [PDF]

Pharmaceuticals
Background: To battle the side effects of anticancer Pt(II) drug cisplatin, the development of photoactivatable and/or intracellular reduction-activatable Pt(IV) prodrugs has become a promising strategy. Methods: Herein, two novel Pt(IV) prodrugs, namely,
Panxing Qiu, Yu Zhang, Yang Dou, Zhijin Cheng, Xiaoqin Wu, Silong Zhang, Fuyi Wang, Kui Wu   +7 more
doaj   +2 more sources

Combined Inhibition of TRPM4/NMDA Receptor Complex and Extrasynaptic NMDA Receptors Is Candidate Therapeutic Target for Suppression of Epileptic Seizures and Improvement of Cognitive Impairments [PDF]

Pharmacology Research & Perspectives
Cognitive impairments are important therapeutic targets in epilepsy medication; however, effective pharmacological treatments for epilepsy patients with comorbid cognitive impairment have not been established. Effects of chronic administration of MK‐801 (
Motohiro Okada, Ruri Okubo, Tomoka Oka, Eishi Motomura   +3 more
doaj   +2 more sources