Results 31 to 40 of about 13,492 (207)

Probenecid Disrupts a Novel Pannexin 1-Collapsin Response Mediator Protein 2 Interaction and Increases Microtubule Stability

Frontiers in Cellular Neuroscience, 2018
Neurite formation relies on finely-tuned control of the cytoskeleton. Here we identified a novel protein-protein interaction between the ion and metabolite channel protein Pannexin 1 (Panx1) and collapsin response mediator protein 2 (Crmp2), a positive ...
Xiaoxue Xu, Leigh E. Wicki-Stordeur, Juan C. Sanchez-Arias, Mei Liu, Mei Liu, Maria S. Weaver, Catherine S. W. Choi, Leigh A. Swayne, Leigh A. Swayne, Leigh A. Swayne   +9 more
doaj   +1 more source

Probenecid inhibits the human bitter taste receptor TAS2R16 and suppresses bitter perception of salicin.

PLoS ONE, 2011
Bitter taste stimuli are detected by a diverse family of G protein-coupled receptors (GPCRs) expressed in gustatory cells. Each bitter taste receptor (TAS2R) responds to an array of compounds, many of which are toxic and can be found in nature.
Tiffani A Greene, Suzanne Alarcon, Anu Thomas, Eli Berdougo, Benjamin J Doranz, Paul A S Breslin, Joseph B Rucker   +6 more
doaj   +1 more source

1‐Azabicyclo[1.1.0]butanes (ABBs) on the Map: Mechanistic Pathways for Catalytic Ring Opening and Functionalizations

Angewandte Chemie, EarlyView.
Catalytic strain‐release ring opening and functionalizations of 1‐azabicyclo[1.1.0]butanes (ABBs) represent a promising strategy for accessing diverse azetidine products. These transformations proceed via polar pathways, radical pathways, and hybrid mechanisms that combine both.
James Shao‐Jiun Yang, Hsuan‐Hung Liao   +1 more
wiley   +2 more sources

Probenecid-Blocked Pannexin-1 Channel Protects Against Early Brain Injury via Inhibiting Neuronal AIM2 Inflammasome Activation After Subarachnoid Hemorrhage

Frontiers in Neurology, 2022
AimPrevious studies have proved that inhibiting inflammasome activation provides neuroprotection against early brain injury (EBI) after subarachnoid hemorrhage (SAH), which is mainly focused on the microglial inflammatory response, but the potential role
Yonghe Zheng, Wenwen Tang, Hanhai Zeng, Yucong Peng, Xiaobo Yu, Feng Yan, Shenglong Cao   +6 more
doaj   +1 more source

Screening Drugs for Broad-Spectrum, Host-Directed Antiviral Activity: Lessons from the Development of Probenecid for COVID-19

Viruses, 2023
In the early stages of drug discovery, researchers develop assays that are compatible with high throughput screening (HTS) and structure activity relationship (SAR) measurements.
Ralph A. Tripp, David E. Martin
doaj   +1 more source

Probenecid Inhibits Respiratory Syncytial Virus (RSV) Replication

, 2022
RNA viruses like SARS-CoV-2, influenza virus, and respiratory syncytial virus (RSV) are dependent on host genes for replication. We investigated if probenecid, an FDA-approved and safe urate-lowering drug that inhibits organic anion transporters (OATs ...
Tripp, Ralph A., Jackelyn Murray, Sancilio, Fred D., Zachary Beau Reener, Bergeron, Harrison C., Ralph A. Tripp, Martin, David E., Reener, Zachary Beau, Les P. Jones, Harrison C. Bergeron, Jones, Les P., David E. Martin, Murray, Jackelyn, Fred D. Sancilio   +13 more
core   +1 more source

Novel (sulfated) thyroid hormone transporters in the solute carrier 22 family

European Thyroid Journal, 2023
Objective: Thyroid hormone (TH) transport represents a critical first step in governing intracellular TH regulation. It is still unknown whether the full repertoire of TH transporters has been identified.
Zhongli Chen, Robin P Peeters, Wesley Flach, Linda J de Rooij, Sena Yildiz, Alexander Teumer, Matthias Nauck, Rosalie B T M Sterenborg, Joost H W Rutten, Marco Medici, W Edward Visser, Marcel E Meima   +11 more
doaj   +1 more source

Mouse echocardiographic data from WT control, WT treated with probenecid, Hsp20 S10F control, and Hsp20 S10F treated with probenecid at Post P2.

, 2020
Mouse echocardiographic data from WT control, WT treated with probenecid, Hsp20 S10F control, and Hsp20 S10F treated with probenecid at Post P2.
Michael R. McDermott (8630307), Nathan Robbins (491110), Evangelia G. Kranias (6834917), Sheryl E. Koch (8630313), Jack Rubinstein (491112), Guansheng Liu (8630310), Evan Onusko (793856)   +6 more
core   +1 more source

Pharmacological mechanisms of probenecid for SARS-CoV-2 and RSV co-infection: findings of system pharmacology, molecular docking, molecular dynamics simulation, and structure–activity relationship

Frontiers in Microbiology
BackgroundThe clinical consequences of the co-infection with novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and respiratory syncytial virus (RSV) are not optimistic.
Junbin Hong, Zhendong Guo, XiaoMei Huang, Peng Wu, Xinying Chen, Xiaoyi Liu, Jinghua Yang, Yanni Lai   +7 more
doaj   +1 more source

Inhibition of probenecid uricosuria by pyrazinamide and para-aminohippurate

, 1977
Both para-aminohippurate (PAH) and pyrazinamide inhibited the uricosuric response to probenecid administration. The mechanism of this inhibition of probenecid uricosuria was assessed in 18 male subjects.
H. S. Diamond, A. D. Meisel
core   +1 more source