Results 21 to 30 of about 13,492 (207)
Probenecid Inhibits NLRP3 Inflammasome Activity and Mitogen-Activated Protein Kinases (MAPKs)
BiomoleculesProbenecid has long been a versatile drug in pharmacological therapies, primarily known for blocking active tubular secretion in the kidney, affecting both endogenous substances like uric acid and exogenous ones like penicillin.
Les P. Jones +4 more
doaj +2 more sources
Frontiers in Pharmacology, 2021 Objectives: Probenecid is an anion transport inhibitor, which, according to the connectivity map (CMap; a biological application database), interferes with hypoxia-induced gene expression changes in retinal vascular endothelial cells (ECs).
Jingbo Jiang +10 more
doaj +1 more source
Correction: Neuroprotective effects of the pannexin-1 channel inhibitor: probenecid on spinal cord injury in rats [PDF]
Frontiers in Molecular NeuroscienceQi Qi +14 more
doaj +2 more sources
Frontiers in Molecular Neuroscience, 2022 Proinflammatory immune cell subsets constitute the majority in the local microenvironment after spinal cord injury (SCI), leading to secondary pathological injury.
Qi Qi +14 more
doaj +1 more source
Therapeutic Advances in Medical Oncology, 2022 Introduction: In breast cancer patients treated with the anti-estrogen tamoxifen, low concentrations of the active metabolite endoxifen are associated with more disease recurrence.
Stefan A. J. Buck +12 more
doaj +1 more source
Competative inhibition of renal tubular secretion of gemifloxacin by probenecid [PDF]
, 2009 Probenecid interacts with transport processes of drugs at several sites in the body. For most quinolones, renal clearance is reduced by concomitant administration of probenecid. The interaction between gemifloxacin and probenecid has not yet been studied.
Kinzig, Martina +6 more
core +1 more source
Zinc uptake into fibroblasts is inhibited by probenecid [PDF]
, 1998 Cellular zinc transport has not been fully characterized. The role of an anion carrier was investigated by treating normal human fibroblasts, and those carrying a mutation which affects zinc transport, acrodermatitis enteropathica (AE), with the anion ...
Muga, Stephanie J +5 more
core +1 more source
Assessing a potential role of host Pannexin 1 during Chlamydia trachomatis infection. [PDF]
PLoS ONE, 2013 Pannexin 1 (Panx1) is a plasma membrane channel glycoprotein that plays a role in innate immune response through association with the inflammasome complex.
Mary J McKuen +2 more
doaj +1 more source
, 2022 Introduction: 3-[18F]fluoro-α-methyl-L-tyrosine ([18F]FAMT) is a promising amino acid tracer targeting L-type amino acid transporter 1 (LAT1). One concern regarding the diagnosis using [18F]FAMT is the possibility of false-negative findings because of ...
Ayaka, Kanai +16 more
core +1 more source
Lack of antiviral activity of probenecid in vitro and in Syrian golden hamsters. [PDF]
, 2023 Antiviral interventions are required to complement vaccination programmes and reduce the global burden of COVID-19. Prior to initiation of large-scale clinical trials, robust preclinical data to support candidate plausibility are required.
Caygill, Claire +32 more
core +1 more source