Results 21 to 30 of about 10,907 (165)

Probenecid Pre-treatment Downregulates the Kidney Cl-/HCO3- Exchanger (Pendrin) and Potentiates Hydrochlorothiazide-Induced Diuresis

Frontiers in Physiology, 2018
Background: Probenecid is a uricosuric agent that in addition to exerting a positive ionotropic effect in the heart, blocks the ATP transporter Pannexin 1 and inhibits the Cl-/HCO3- exchanger, pendrin.
Sharon Barone, Sharon Barone, Jie Xu, Jie Xu, Kamyar Zahedi, Kamyar Zahedi, Marybeth Brooks, Manoocher Soleimani, Manoocher Soleimani, Manoocher Soleimani   +9 more
doaj   +1 more source

Influence of probenecid on endoxifen systemic exposure in breast cancer patients on adjuvant tamoxifen treatment

Therapeutic Advances in Medical Oncology, 2022
Introduction: In breast cancer patients treated with the anti-estrogen tamoxifen, low concentrations of the active metabolite endoxifen are associated with more disease recurrence.
Stefan A. J. Buck, C. Louwrens Braal, Maaike M. Hofman, Esther Oomen-de Hoop, Peter de Bruijn, Inge M. Ghobadi Moghaddam-Helmantel, Koen G. A. M. Hussaarts, Mijntje B. Vastbinder, Quirine C. van Rossum-Schornagel, Ron H. N. van Schaik, Agnes Jager, Stijn L. W. Koolen, Ron H. J. Mathijssen   +12 more
doaj   +1 more source

Probenecid treatment improves outcomes in a novel mouse model of peripartum cardiomyopathy.

PLoS ONE, 2020
Probenecid has been used for decades in the treatment of gout but recently has also been found to improve outcomes in patients with heart failure via stimulation of the transient receptor potential vanilloid 2 (TRPV2) channel in cardiomyocytes.
Evan Onusko, Michael R McDermott, Nathan Robbins, Guansheng Liu, Evangelia G Kranias, Jack Rubinstein, Sheryl E Koch   +6 more
doaj   +1 more source

Probenecid slows disease progression in a murine model of autosomal dominant polycystic kidney disease

Physiological Reports, 2023
Development of autosomal dominant polycystic kidney disease (ADPKD) involves renal epithelial cell abnormalities. Cystic fluid contains a high level of ATP that, among other effects, leads to a reduced reabsorption of electrolytes in cyst‐lining cells ...
Sergey N. Arkhipov, D'Anna L. Potter, Regina F. Sultanova, Daria V. Ilatovskaya, Peter C. Harris, Tengis S. Pavlov   +5 more
doaj   +1 more source

Effect of Probenecid on Pharmacokinetics and Tolerability of Olmesartan in Healthy Chinese Volunteers

Current Therapeutic Research, 2014
Background: Olmesartan is an angiotensin II receptor antagonist and is effective and well tolerated in the treatment of arterial hypertension. Probenecid is a well-established hypouricemic agent for the treatment of hyperuricemia and gout. Objective: The
Kun-Yan Li, PhD, Yu Qiu, MS, Yun Jiang, BS, Chen-Hui Luo, MS, Xiao-Ping Lin, BS, Jing Wang, BS, Nong Yang, MS   +6 more
doaj   +1 more source

Assessing a potential role of host Pannexin 1 during Chlamydia trachomatis infection. [PDF]

PLoS ONE, 2013
Pannexin 1 (Panx1) is a plasma membrane channel glycoprotein that plays a role in innate immune response through association with the inflammasome complex.
Mary J McKuen, Gerhard Dahl, Kenneth A Fields   +2 more
doaj   +1 more source

Probenecid Disrupts a Novel Pannexin 1-Collapsin Response Mediator Protein 2 Interaction and Increases Microtubule Stability

Frontiers in Cellular Neuroscience, 2018
Neurite formation relies on finely-tuned control of the cytoskeleton. Here we identified a novel protein-protein interaction between the ion and metabolite channel protein Pannexin 1 (Panx1) and collapsin response mediator protein 2 (Crmp2), a positive ...
Xiaoxue Xu, Leigh E. Wicki-Stordeur, Juan C. Sanchez-Arias, Mei Liu, Mei Liu, Maria S. Weaver, Catherine S. W. Choi, Leigh A. Swayne, Leigh A. Swayne, Leigh A. Swayne   +9 more
doaj   +1 more source

Probenecid inhibits the human bitter taste receptor TAS2R16 and suppresses bitter perception of salicin.

PLoS ONE, 2011
Bitter taste stimuli are detected by a diverse family of G protein-coupled receptors (GPCRs) expressed in gustatory cells. Each bitter taste receptor (TAS2R) responds to an array of compounds, many of which are toxic and can be found in nature.
Tiffani A Greene, Suzanne Alarcon, Anu Thomas, Eli Berdougo, Benjamin J Doranz, Paul A S Breslin, Joseph B Rucker   +6 more
doaj   +1 more source

Cobalt‐Catalyzed Radical Ligand Transfer (RLT) Enables Remote‐Markovnikov Hydroamination of Alkenes

Angewandte Chemie, EarlyView.
A cobalt‐catalyzed remote‐Markovnikov 1,3‐hydroamination of allyl carboxylates proceeds through MHAT, 1,2‐radical acyloxy migration (1,2‐RAM), and radical ligand transfer (RLT) from a Co‐N intermediate, providing protected amino alcohols. ABSTRACT Amino alcohols are prevalent in pharmaceuticals, agrochemicals, and functional materials, yet ...
Arman Khosravi, Ho Martin Yuen, Seth Fremin, Nuwan A. Pannilawithana, Nol Supasueb, Yu Zhang, Peng Liu, Ming‐Yu Ngai   +7 more
wiley   +2 more sources

Probenecid-Blocked Pannexin-1 Channel Protects Against Early Brain Injury via Inhibiting Neuronal AIM2 Inflammasome Activation After Subarachnoid Hemorrhage

Frontiers in Neurology, 2022
AimPrevious studies have proved that inhibiting inflammasome activation provides neuroprotection against early brain injury (EBI) after subarachnoid hemorrhage (SAH), which is mainly focused on the microglial inflammatory response, but the potential role
Yonghe Zheng, Wenwen Tang, Hanhai Zeng, Yucong Peng, Xiaobo Yu, Feng Yan, Shenglong Cao   +6 more
doaj   +1 more source