Results 41 to 50 of about 18,678 (212)

A Human-Derived Monoclonal Antibody Targeting Extracellular Connexin Domain Selectively Modulates Hemichannel Function [PDF]

, 2019
Connexin hemichannels, which are plasma membrane hexameric channels (connexons) composed of connexin protein protomers, have been implicated in a host of physiological processes and pathological conditions. A number of single point pathological mutations
Buratto, Damiano, Carrer, Andrea, Chiani, Francesco, Kuang, Yuanyuan, Lerner, Richard A, Mammano, Fabio, Nardin, Chiara, Paludetti, Gaetano, Salvatore, Anna Maria, Xu, Liang, Yang, Guang, Ziraldo, Gaia, Zonta, Francesco   +12 more
core   +1 more source

Multidrug resistance protein 4/ ATP binding cassette transporter 4: a new potential therapeutic target for acute myeloid leukemia [PDF]

, 2014
Less than a third of adults patients with acute myeloid leukemia (AML) are cured by current treatments, emphasizing the need for new approaches to therapy.
Beyrath, Julien, Bruzzone, Ariana, Cany, Jeannette, Copsel, Sabrina Natalia, Davio, Carlos Alberto, May, Maria, Russel, Frans G. M., Shayo, Carina Claudia, Wargon, Victoria   +8 more
core   +2 more sources

Organic Anion and Cation Transporter Expression and Function During Embryonic Kidney Development and in Organ Culture Model Systems [PDF]

, 2006
Background Organic anion and cation transporters (OATs, OCTs and OCTNs) mediate the proximal tubular secretion of numerous clinically important compounds, including various commonly prescribed pharmaceuticals.
Bush, Kevin T., Eraly, Satish A., Nigam, Sanjay K., Sweet, Douglas H.   +3 more
core   +2 more sources

Probenecid‐Boosted Tenofovir: A Physiologically‐Based Pharmacokinetic Model‐Informed Strategy for On‐Demand HIV Preexposure Prophylaxis

CPT: Pharmacometrics & Systems Pharmacology, 2020
Multiple doses of tenofovir disoproxil fumarate (TDF) together with emtricitabine is effective for HIV preexposure prophylaxis (PrEP). TDF is converted to tenofovir (TFV) in circulation, which is subsequently cleared via tubular secretion by organic ion ...
Stephanie N. Liu, Zeruesenay Desta, Brandon T. Gufford   +2 more
doaj   +1 more source

The mechanisms of detoxification of As(III), dimethylarsinic acid (DMA) and As(V) in the microalga Chlorella vulgaris [PDF]

, 2016
The response of Chlorella vulgaris when challenged by As(III), As(V) and dimethylarsinic acid (DMA) was assessed through experiments on adsorption, efflux and speciation of arsenic (reduction, oxidation, methylation and chelation with glutathione ...
A. Raab, Abedin, Amayo, Batista, Berlich, Bettencourt, Bluemlein, Chassaigne, Collin-Hansen, Cordula, Cossarizza, Cuypers, D. Purchase, D. Urgast, Forestier, Gayet, Gregus, Grill, H. Garelick, H. Jones, Hadjoudja, Hirata, J. Feldmann, Jasinski, Jiang, Jones, Kala, Kang, Karajova, Klapheck, Klapheck, Knauer, Kubota, L. Pantoja Munoz, Lebedeva, Lee, Levy, Li, Liu, Long, Lu, Mayer, Meharg, Mishra, Mounicou, Nacorda, Nemeti, Nemeti, Nobel, Oven, Pantoja, Park, Pawlik-Skowronska, Perales-Vela, Prévéral, Raab, Rahman, Rehman, Rubinos, Sandau, Scherer, Shahid, Simmons, Simmons, Song, Sooksa-Nguan, Steinberg, Steinberg, Stolz, Suhendrayatna Ohki, Swanson, Tsuji, Wang, Wang, Wojas, Wong, Xu, Young, Zhang, Zouboulis   +79 more
core   +1 more source

Restraint stress increases hemichannel activity in hippocampal glial cells and neurons [PDF]

, 2015
Stress affects brain areas involved in learning and emotional responses, which may contribute in the development of cognitive deficits associated with major depression.
Carola J. Maturana, Jimmy Stehberg, Juan A. Orellana, Juan C. Sáez, Raúl Díaz-Galarce, Rodrigo Moraga-Amaro, Sebastián Rojas   +6 more
core   +3 more sources

Probenecid-Blocked Pannexin-1 Channel Protects Against Early Brain Injury via Inhibiting Neuronal AIM2 Inflammasome Activation After Subarachnoid Hemorrhage

Frontiers in Neurology, 2022
AimPrevious studies have proved that inhibiting inflammasome activation provides neuroprotection against early brain injury (EBI) after subarachnoid hemorrhage (SAH), which is mainly focused on the microglial inflammatory response, but the potential role
Yonghe Zheng, Wenwen Tang, Hanhai Zeng, Yucong Peng, Xiaobo Yu, Feng Yan, Shenglong Cao   +6 more
doaj   +1 more source

Substrate‐Affinitive P‐Type Azapolycyclic Photosensitizer for Chemoselective Nitrilization Under Mild Conditions

Advanced Science, EarlyView.
We developed a series of quinoxalinoquinoxaline (QQ) photosensitizers featuring high and tunable excited‐state reduction potentials (E(PC•+/PC*) = –1.76 to –2.05 V vs. SCE). Their hydrogen‐bonding interaction with carbonyl substrates enables selective single‐electron transfer events for selective nitrilization of 1° amides, offering a tunable ...
Seongwoo Bae, Dongwook Kim, Jinwoo Kim
wiley   +1 more source

Uric Acid Has Direct Proinflammatory Effects on Human Macrophages by Increasing Proinflammatory Mediators and Bacterial Phagocytosis Probably via URAT1

Biomolecules, 2020
The relationship of uric acid with macrophages has not been fully elucidated. We investigated the effect of uric acid on the proinflammatory ability of human macrophages and then examined the possible molecular mechanism involved. Primary human monocytes
Camilo P. Martínez-Reyes, Aarón N. Manjarrez-Reyna, Lucia A. Méndez-García, José A. Aguayo-Guerrero, Beatriz Aguirre-Sierra, Rafael Villalobos-Molina, Yolanda López-Vidal, Karen Bobadilla, Galileo Escobedo   +8 more
doaj   +1 more source

Screening Drugs for Broad-Spectrum, Host-Directed Antiviral Activity: Lessons from the Development of Probenecid for COVID-19

Viruses, 2023
In the early stages of drug discovery, researchers develop assays that are compatible with high throughput screening (HTS) and structure activity relationship (SAR) measurements.
Ralph A. Tripp, David E. Martin
doaj   +1 more source