Results 41 to 50 of about 13,492 (207)
Effect of probenecid on disposition kinetics of ampicillin in horses
, 1992 The effect of an oral dose of probenecid on the disposition kinetics of ampicillin was determined in four horses. An intravenous bolus dose (10 mg/kg) of ampicillin sodium was administered to the horses on two occasions.
Sarasola, P., McKellar, Quintin
core +4 more sources
CPT: Pharmacometrics & Systems Pharmacology, 2020 Multiple doses of tenofovir disoproxil fumarate (TDF) together with emtricitabine is effective for HIV preexposure prophylaxis (PrEP). TDF is converted to tenofovir (TFV) in circulation, which is subsequently cleared via tubular secretion by organic ion ...
Stephanie N. Liu +2 more
doaj +1 more source
, 2020 Mouse echocardiographic data from WT control, WT treated with probenecid, Hsp20 S10F control, and Hsp20 S10F treated with probenecid at baseline.
Michael R. McDermott (8630307) +6 more
core +1 more source
Caregiver Perspectives on the Burden of Disease and Treatment in Uncontrolled Gout
Arthritis Care &Research, EarlyView.Objective Uncontrolled gout (UG) refers to persistently elevated serum urate (SU) levels >6 mg/dL and ongoing gout symptoms despite use of urate‐lowering therapy (ULT). The objective of this study was to evaluate the burden associated with informal caregiving for individuals with UG.
Angelo Gaffo +6 more
wiley +1 more source
Arthritis Care &Research, Accepted Article.Objective Routine liver enzyme monitoring is advocated while on allopurinol but supporting guidance is lacking. We assessed the incidence and factors associated with elevated liver enzymes in gout patients commenced on allopurinol. Methods 150 patients with gout and normal baseline serum aminotransferases initiated on allopurinol were followed ...
May Shuen Tang +4 more
wiley +1 more source
Physiologically Based Pharmacokinetic Models of Probenecid and Furosemide to Predict Transporter Mediated Drug-Drug Interactions [PDF]
, 2020 Purpose To provide whole-body physiologically based pharmacokinetic (PBPK) models of the potent clinical organic anion transporter (OAT) inhibitor probenecid and the clinical OAT victim drug furosemide for their application in transporter-based drug ...
Prasad, Bhagwat +8 more
core +2 more sources
Addition of probenecid to oral β-lactam antibiotics: a systematic review and meta-analysis [PDF]
, 2022 Objectives: To explore the literature comparing the pharmacokinetic and clinical outcomes from adding probenecid to oral β-lactams. Methods: Medline and EMBASE were searched from inception to December 2021 for all English language studies comparing the ...
Holmes, Alison H +15 more
core +1 more source
Cells, 2020 ABCC6, belonging to sub-family C of ATP-binding cassette transporter, is an ATP-dependent transporter mainly present in the basolateral plasma membrane of hepatic and kidney cells.
Angela Ostuni +8 more
doaj +1 more source
Versatile Detection of Cellular Protein via Fluorescence Anisotropy
Advanced Science, EarlyView.Cell Lysate Fluorescence Anisotropy (CFAST) utilizes long lifetime dye‐labeled nanobodies for rapid protein quantification in minimally purified, complex cell lysate. When coupled with cellular thermal shift, CFAST allows high‐throughput detection of endogenous protein‐small molecule engagement, facilitating the discovery of novel binders for ...
Qing Tang +12 more
wiley +1 more source
Effects of probenecid on gene expression.
, 2015 A: Genes up-regulated in cells incubated in pre- and post dialysis plasma returned toward baseline with added probenecid. B: Genes down-regulated in cells incubated in pre- and post dialysis plasma returned toward baseline with added probenecid.
Sachin Jhawar (712700) +9 more
core +1 more source