Results 41 to 50 of about 10,907 (165)
Pharmaceutics, 2020 Acamprosate is an anionic drug substance widely used in treating symptoms of alcohol withdrawal. It was recently shown that oral acamprosate absorption is likely due to paracellular transport.
Irina E. Antonescu +8 more
doaj +1 more source
Retro‐Hetero‐Michael Addition Strategies in Organic Synthesis
European Journal of Organic Chemistry, EarlyView.In this review, synthetic approaches to carbo‐ and heterocyclic compounds, including natural products, published in the last 15 years (2011–2025) which have either relied upon or included a retro‐hetero‐Michael addition step at any stage are discussed.
Dina Scarpi, Ernesto G. Occhiato
wiley +1 more source
Amoxicillin and Ceftriaxone as Treatment Alternatives to Penicillin for Maternal Syphilis
Emerging Infectious Diseases, 2017 There is no proven alternative to penicillin for treatment of maternal syphilis. We report 2 case-patients with maternal syphilis who were successfully treated without penicillin.
Yuichi Katanami +8 more
doaj +1 more source
Epilepsia, EarlyView.Abstract This article summarizes data for 13 investigational treatments for which at least preliminary seizure outcome data in patients with epilepsy were reported at the Eighteenth Eilat Conference on New Antiepileptic Drugs and Devices held in Madrid, Spain, on May 3–6, 2026.
Meir Bialer +7 more
wiley +1 more source
Epilepsia, EarlyView.Abstract Over the last 34 years, the Eilat Conference on New Antiepileptic Drugs and Devices has provided an interactive forum for stakeholders to discuss investigational and recently licensed treatments for seizures and epilepsy. The Eighteenth Eilat Conference on New Antiepileptic Drugs and Devices (EILAT XVIII) took place in Madrid, Spain, on May 3 ...
Meir Bialer +7 more
wiley +1 more source
Triggered Calcium Lightning Programs Cochlear Development
Exploration, EarlyView.Summary: Before the onset of hearing, the developing inner ear generates spontaneous calcium signals that are thought to guide maturation. In this study, we discovered a rapid and widespread calcium flash—dubbed “Ca2+ lightning”—originating from supporting cells beneath the sensory hair cells, which triggers coordinated calcium waves across the entire ...
Qiang Ma +13 more
wiley +1 more source
The FEBS Journal, EarlyView.A targeted phototoxic peptide selectively accumulates in cells expressing chemokine‐like receptor 1 (CMKLR1). Phototoxicity of the native peptide is low, but cleavage by lysosomal protease cathepsin B releases a 6‐tetramethylrhodamine (TMR) labeled nona‐ᴅ‐arginine which mediates lysosomal rupture and cell death upon irradiation.
Moritz List +2 more
wiley +1 more source
Biomolecules, 2020 The relationship of uric acid with macrophages has not been fully elucidated. We investigated the effect of uric acid on the proinflammatory ability of human macrophages and then examined the possible molecular mechanism involved. Primary human monocytes
Camilo P. Martínez-Reyes +8 more
doaj +1 more source
Treatment Goals for Primary Biliary Cholangitis, an Australian Perspective
Journal of Gastroenterology and Hepatology, EarlyView.ABSTRACT Primary biliary cholangitis (PBC) is an autoimmune liver disease that targets the small intrahepatic bile ducts with diagnosis based on elevated serum alkaline phosphatase (ALP) levels and the presence of anti‐mitochondrial antibodies. Untreated, it may run a progressive course to cirrhosis and hepatic decompensation, at which point liver ...
Simone I. Strasser +6 more
wiley +1 more source
Transplant Infectious Disease, EarlyView.Among 135 cases of post‐liver transplant HHV8 disease (4 from NSW), presentations varied, and mortality was high (44%). Donor screening was rare, and donor‐derived infection was suspected in 33%. Survival improved with mTORi, reduced immunosuppression, chemotherapy, and, for non‐KS disease, donor screening. ABSTRACT Background Human herpesvirus 8 (HHV8)
Karen M. J. Waller +12 more
wiley +1 more source