Results 61 to 70 of about 10,907 (165)

A stability-indicating RP-HPLC method for simultaneous estimation of sulopenem etzadroxil and probenecid in bulk drug and combined tablet dosage form

Discover Chemistry
An economical, sensitive, robust, and stability-indicating RP-HPLC method was developed for the simultaneous estimation of Sulopenem Etzadroxil and Probenecid in binary mixture and combined tablet dosage forms.
Ramreddy Godela, Krishnaphanisri Ponnekanti, Anusha Polagani   +2 more
doaj   +1 more source

Synthesis, Characterization, and Analysis of Probenecid and Pyridine Compound Salts

Crystals
This study aimed to address the issue of the low solubility in the model drug probenecid (PRO) and its impact on bioavailability. Two salts of probenecid (PRO), 4-aminopyridine (4AMP), and 4-dimethylaminopyridine (4DAP) were synthesized and characterized
Menglong Zhang, Xinyu Hou, Fuhai Yu, Liang Zhang, Baohong Hou, Lina Zhou, Chuang Xie, Songgu Wu, Wei Chen   +8 more
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Smilagenin Protects Dopaminergic Neurons in Chronic MPTP/Probenecid—Lesioned Parkinson’s Disease Models

Frontiers in Cellular Neuroscience, 2019
Current therapies for Parkinson’s disease (PD) only offer limited symptomatic alleviation but fail to hamper the progress of the disease. Thus, it is imperative to establish new approaches aiming at protecting or reversing neurodegeneration in PD. Recent
Xuan He, Shuangshuang Yang, Rui Zhang, Lina Hou, Jianrong Xu, Yaer Hu, Rang Xu, Hao Wang, Yongfang Zhang   +8 more
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Effects of probenecid and cimetidine on the pharmacokinetics of nemonoxacin in healthy Chinese volunteers

Drug Design, Development and Therapy, 2016
Yi-fan Zhang,1 Xiao-jian Dai,1 Yong Yang,1 Xiao-yan Chen,1 Ting Wang,2 Yun-biao Tang,3 Cheng-yuan Tsai,4 Li-wen Chang,4 Yu-ting Chang,4 Da-fang Zhong1 1State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of ...
Zhang YF, Dai XJ, Yang Y, Chen XY, Wang T, Tang YB, Tsai CY, Chang LW, Chang YT, Zhong DF   +9 more
doaj  

Colon-Specific Delivery of Probenecid Enhances Therapeutic Activity of the Uricosuric Agent Against Rat Colitis

Pharmaceutics
Background/Objectives: Probenecid (PBN) is a uricosuric agent that facilitates the excretion of uric acid and is used to treat gout. Here, a colon-targeted prodrug of PBN was designed to facilitate repositioning as a treatment for inflammatory bowel ...
Yeonhee Jeong, Jaejeong Kim, Changyu Kang, Yunjin Jung   +3 more
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Baicalin, Amoxicillin, and Probenecid Provide Protection in Mice Against Glaesserella parasuis Challenge

Biomolecules
Glaesserella parasuis (G. parasuis) causes Glässer’s disease and systemic inflammatory responses in the host. The currently available therapies have limited efficacy and fail to achieve a balance between anti-inflammatory and antibacterial effects.
Jingyang Li, Ronghui Luo, Yunjian Fu, Siyu Liu, Qiaoli Dong, Yamin Sun, Xinyue Tian, Yi Zhu, Peiyi Wang, Ling Guo, Qirong Lu, Chun Ye, Shulin Fu, Yinsheng Qiu   +13 more
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Evaluating Probenecid or Oseltamivir Inhibition of Influenza A Virus Replication Through Plaque Assay or Fluorescent Focus Assay Using Non-Structural Protein 1–H1N1 Venus Reporter Virus

Viruses
It is essential to understand the molecular mechanisms of influenza antiviral therapeutics to evaluate their efficacy. Virus plaque assays are commonly used to assess the antiviral effects of drugs on virus replication; however, this method is labor ...
Jackelyn Murray, Aitor Nogales, Luis Martinez-Sobrido, David E. Martin, Fred D. Sancilio, Ralph A. Tripp   +5 more
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AKTIVITAS ANTIHIPERURIKEMIA EKSTRAK ETIL ASETAT DAN ETANOL BUAH SALAK VARIETAS BONGKOK (Salacca edulis Reinw.) PADA TIKUS GALUR WISTAR [Antihyperuricemic Activity of Ethyl Acetate and Ethanol Extracts of Snake Fruit var. Bongkok (Salacca edulis Reinw.) on Wistar Rat]

Jurnal Teknologi dan Industri Pangan, 2011
The aims of the study was to determine antihyperuricemic activity of ethyl acetate and ethanol extractsof snake fruit (Salacca edulis Reinw.) var. Bongkok on Wistar male rats.
Leni Herliani Afrianti1)*, Elin Yulinah Sukandar2), I Ketut Adnyana2), Slamet Ibrahim3)   +3 more
doaj  

Experimental and computational biophysics to identify vasodilator drugs targeted at TRPV2 using agonists based on the probenecid scaffold

Computational and Structural Biotechnology Journal
TRP channels are important pharmacological targets in physiopathology. TRPV2 plays distinct roles in cardiac and neuromuscular function, immunity, and metabolism, and is associated with pathologies like muscular dystrophy and cancer.
Èric Catalina-Hernández, Mario López-Martín, David Masnou-Sánchez, Marco Martins, Victor A. Lorenz-Fonfria, Francesc Jiménez-Altayó, Ute A. Hellmich, Hitoshi Inada, Antonio Alcaraz, Yuji Furutani, Alfons Nonell-Canals, Jose Luis Vázquez-Ibar, Carmen Domene, Rachelle Gaudet, Alex Perálvarez-Marín   +14 more
doaj   +1 more source

AKTIVITAS ANTIHIPERURIKEMIA EKSTRAK ETIL ASETAT DAN ETANOL BUAH SALAK VARIETAS BONGKOK (Salacca edulis Reinw.) PADA TIKUS GALUR WISTAR [Antihyperuricemic Activity of Ethyl Acetate and Ethanol Extracts of Snake Fruit var. Bongkok (Salacca edulis Reinw.) o

Jurnal Teknologi dan Industri Pangan, 2011
The aims of the study was to determine antihyperuricemic activity of ethyl acetate and ethanol extractsof snake fruit (Salacca edulis Reinw.) var. Bongkok on Wistar male rats. Wistar male rats administered with 100 and 200 mg/kg b.w ethyl acetat extract
Leni Herliani Afrianti, Elin Yulinah Sukandar, I Ketut Adnyana, Slamet Ibrahim -   +3 more
doaj