Critical role of the mast cell/tryptase/PAR2 axis in anastrozole‐induced pain
British Journal of Pharmacology, Volume 183, Issue 9, Page 2009-2027, May 2026.Abstract Background and Purpose Anastrozole, an aromatase inhibitor, is used to treat postmenopausal women with hormone receptor‐positive breast cancer, but also induces musculoskeletal pain and can lead to therapeutic regimen suspension. Aromatase inhibitors promote the release of pro‐inflammatory substances from sensitised nerve fibres, which might ...
Maria Fernanda Pessano Fialho +5 more
wiley +1 more source
Probenecid blocks human P2X7 receptor-induced dye uptake via a pannexin-1 independent mechanism. [PDF]
PLoS ONE, 2014 P2X7 is a ligand-gated ion channel which is activated by ATP and displays secondary permeability characteristics. The mechanism of development of the secondary permeability pathway is currently unclear, although a role for the hemichannel protein ...
Archana Bhaskaracharya +7 more
doaj +1 more source
Predicting Pharmacokinetic Variability and Drug Interaction Risk Using Omics‐Based Biomarkers
Clinical and Translational Science, Volume 19, Issue 5, May 2026.ABSTRACT Interindividual variability in drug pharmacokinetics and susceptibility to drug–drug interactions remain major barriers in precision dosing, particularly for narrow therapeutic index drugs. While genetic factors contribute, much variability arises from dynamic influences such as physiology, disease, age, diet, microbiome, and concomitant ...
Bhagwat Prasad
wiley +1 more source
Probenecid Inhibits Human Metapneumovirus (HMPV) Replication In Vitro and in BALB/c Mice
VirusesHuman metapneumovirus (HMPV) is an important cause of acute respiratory tract infection and causes significant morbidity and mortality. There is no specific antiviral drug to treat HMPV or vaccine to prevent HMPV.
Harrison C. Bergeron +4 more
doaj +1 more source
The Effect of N-Terminal Cyclization on the Function of the HIV Entry Inhibitor 5P12-RANTES. [PDF]
, 2017 Despite effective treatment for those living with Human Immunodeficiency Virus (HIV), there are still two million new infections each year. Protein-based HIV entry inhibitors, being highly effective and specific, could be used to protect people from ...
F Nguyen, Anna +3 more
core +2 more sources
Apoptotic effect of a novel kefir product, PFT, on multidrug-resistant myeloid leukemia cells via a hole-piercing mechanism. [PDF]
, 2014 We examined the apoptotic effect of a novel Probiotics Fermentation Technology (PFT) kefir grain product; PFT is a natural mixture composed primarily of Lactobacillus kefiri P-IF, a specific strain of L. kefiri with unique growth characteristics. The aim
Ghoneum, Mamdooh, Gimzewski, James
core +1 more source
How effective is prophylactic therapy for gout in people with prior attacks? [PDF]
, 2004 Colchicine (strength of recommendation [SOR]: B, based on 1 double-blind crossover study), allopurinol (SOR: B, based on 2 cohort studies), and weight loss (SOR: B, based on 1 small cohort study) have been shown to reduce symptomatic recurrences of gout,
Weismantel, Arlene McFarlin +1 more
core
Idiopathic orthostatic hypotension: Recent data (eleven cases) and review of the literature [PDF]
Eight cases of Shy-Drager syndrome and three of Bradbury-Eggleston idiopathic orthostatic hypotension were examined. In all cases, examination of circulatory reflexes showed major dysfunction of the sympathetic vasoconstrictor system.
Annat, G. +9 more
core +1 more source
Nose-to-brain delivery of antiviral drugs: A way to overcome their active efflux? [PDF]
, 2018 Although several viruses can easily infect the central nervous system (CNS), antiviral drugs often show dramatic difficulties in penetrating the brain from the bloodstream since they are substrates of active efflux transporters (AETs). These transporters,
Dalpiaz, Alessandro, Pavan, Barbara
core +2 more sources
Evaluation of known and novel inhibitors of Orai1-mediated store operated Ca2+ entry in MDA-MB-231 breast cancer cells using a Fluorescence Imaging Plate Reader assay [PDF]
, 2016 The Orai1 Ca2+ permeable ion channel is an important component of store operated Ca2+ entry (SOCE) in cells. It's over-expression in basal molecular subtype breast cancers has been linked with poor prognosis, making it a potential target for drug ...
Azimi, Iman +6 more
core +1 more source