Results 81 to 90 of about 13,492 (207)

Variations in the Management of Uncontrolled Gout Between Rheumatologists and Nephrologists: A Retrospective Medical Record Review

ACR Open Rheumatology, Volume 8, Issue 9, September 2026.
Objective To evaluate the management practices of rheumatologists and nephrologists in treating patients with uncontrolled gout. Methods US board‐certified rheumatologists and nephrologists treating patients with uncontrolled gout participated in a web‐based, retrospective medical record audit study, sharing their perceptions of uncontrolled gout ...
Kenneth Saag, Nana Kragh, Amod Athavale, Bhavisha Desai, Amal Gulaid, Abiola Oladapo, Brittany Smith, Hyon Choi   +7 more
wiley   +1 more source

High‐Resolution Imaging of Extracellular pH in Mouse Liver Tumor

NMR in Biomedicine, Volume 39, Issue 9, September 2026.
High‐resolution imaging of extracellular pH (pHe) using 1H‐BIRDS with REduced Spherical Encoding with GAussian Weighting (RESEGAW) was achieved in an orthotopic mouse liver tumor (Hepa1–6) model and was validated with 31P MRSI using 3‐aminopropylphosphonate, showing excellent agreement between the two methods.
Jessica Gois Santana, Sara Kurdi, Lisa Marie Helene Peschke, Sandeep Kumar Mishra, Fahmeed Hyder, Julius Chapiro, Daniel Coman   +6 more
wiley   +1 more source

Population pharmacokinetics of oseltamivir when coadministered with probenecid

, 2008
Oseltamivir is a potent, selective, oral neuraminidase inhibitor for the treatment and prophylaxis of influenza. Plasma concentrations of the active metabolite, oseltamivir carboxylate, are increased in the presence of probenecid, suggesting that the ...
Rayner, Craig R., Jonsson, E Niclas,, Chanu, Pascal, Gieschke, Ronald, Boak, Lauren M.   +4 more
core   +1 more source

Net Renal Drug Secretion Critically Requires Significant Contribution of Basal Uptake Transporters: Perspective From Mechanistic Kidney Model Simulation and Integration of Clinical and In Vitro Data

CPT: Pharmacometrics &Systems Pharmacology, Volume 15, Issue 9, September 2026.
ABSTRACT Renal clearance (CLr) is the net outcome of glomerular filtration, secretion, and reabsorption, which makes the quantitative requirements for net renal secretion difficult to infer from simple clearance models. Using a mechanistic kidney model (MechKiM), we simulated blood‐referenced CLr (CLr,b) for 30,000 virtual drugs (neutral, monoanionic ...
Toshiaki Tsuchitani, Masatoshi Tomi, Yuichi Sugiyama   +2 more
wiley   +1 more source

Probenecid directly impairs activation of the canine P2X7 receptor

, 2017
The current study aimed to determine if probenecid could directly impair the canine P2X7 receptor, a ligand-gated cation channel activated by extracellular adenosine 5′-triphosphate (ATP). Patch clamp measurements demonstrated that probenecid impairs ATP-
Belinda L Curtis (20204340), Rachael Bartlett (8339460), Ronald Sluyter (19586773), Leanne Stokes (543342), Stephen J Curtis (20213178)   +4 more
core  

Comparative study of the effects of baicalin and probenecid on microRNA expression profiles in porcine aortic vascular endothelial cells infected by Glaesserella parasuis

BMC Veterinary Research
Background Glaesserella parasuis elicits severe inflammatory responses and vascular damage, thus resulting in high mortality and morbidity in pigs; consequently, early diagnosis and treatment are critical to controlling economic losses. MicroRNAs (miRNAs)
Ling Guo, Yaqiong Yang, Linrong Yang, Peiyan Sun, Jing He, Shulin Fu, Chun Ye, Bingbing Zong, Yinsheng Qiu   +8 more
doaj   +1 more source

Human Cytomegalovirus Genetic Diversity, Clinical Relevance, and Emerging Insights

Reviews in Medical Virology, Volume 36, Issue 5, September 2026.
ABSTRACT Human cytomegalovirus (HCMV) is a globally prevalent virus that poses a significant public health concern, especially for newborns and immunocompromised patients, causing a wide range of infections. Clinical outcomes associated with HCMV infection include congenital disease, graft rejection in transplant recipients, and life‐threatening ...
Hajar Y. AlQahtani, Fadilah Sfouq Aleanizy, Fulwah Yahya Alqahtani   +2 more
wiley   +1 more source

Pharmacodynamic analysis of the furosemide-probenecid interaction in man [PDF]

, 1979
Pharmacodynamic analysis of the furosemide-probenecid interaction in man. Probenecid pretreatment in man increased the overall response to furosemide in contrast to animal studies in which probenecid decreased response by inhibiting proximal renal ...
Seiwell, Ruth, Chennavasin, Polavat, Brater, D. Craig, Liang, Winnie M.M.   +3 more
core   +1 more source

Systemic medications associate with surgically treated cataract among adults over 50 years in Finland

Acta Ophthalmologica, Volume 104, Issue 6, Page e630-e647, September 2026.
Abstract Purpose To identify associations between systemic drugs and cataract surgery in Finland. Methods A historic cohort study based on administrative data. Endpoint event was cataract surgery. Use of drugs in question was based on redeemed prescriptions and consisted of 156 drugs.
Antti Riikonen, Jari Haukka, Tuomas Lilius, Sirpa Loukovaara   +3 more
wiley   +1 more source

Morphine blood-brain barrier transport is influenced by probenecid co-administration

, 2003
PURPOSE: The objective of this study was to investigate the possible influence of probenecid on morphine transport across the blood-brain barrier (BBB) in rats.
Hammarlund-Udenaes, Margareta,, Jonsson, E Niclas,, Tunblad, Karin,   +2 more
core   +1 more source