Results 91 to 100 of about 13,492 (207)

Sulopenem Etzadroxil/Probenecid

Hospital Pharmacy
Each month, subscribers to The Formulary Monograph Service receive 5 to 6 well-documented monographs on drugs that are newly released or are in late phase 3 trials. The monographs are targeted to Pharmacy & Therapeutics Committees.
Danial E. Baker, Terri L. Levien
openaire   +2 more sources

Treatment Goals for Primary Biliary Cholangitis, an Australian Perspective

Journal of Gastroenterology and Hepatology, Volume 41, Issue 9, Page 2623-2638, September 2026.
ABSTRACT Primary biliary cholangitis (PBC) is an autoimmune liver disease that targets the small intrahepatic bile ducts with diagnosis based on elevated serum alkaline phosphatase (ALP) levels and the presence of anti‐mitochondrial antibodies. Untreated, it may run a progressive course to cirrhosis and hepatic decompensation, at which point liver ...
Simone I. Strasser, Alexander J. Thompson, Rohit Gupta, John Lubel, Janine French, Beverly Sacks, Martin Weltman   +6 more
wiley   +1 more source

Not Quite Folded: Challenges in Predicting the hNPS‐hNPSR‐Ile107 Complex With AlphaFold2 Multimer

ChemMedChem, Volume 21, Issue 16, 27 August 2026.
AlphaFold2 Multimer guided the design of 20 novel human neuropeptide S (hNPS) cyclic analogues. Modelling bias toward the inactive state favoured receptor blockade over activation. Exploiting a stereochemical switch in the peptide hinge region yielded four potent NPS receptor (NPSR) antagonists with pA2 up to 6.20. Lines indicate conformational bridges
Valentina Albanese, Michela Argentieri, Federica Agosta, Alessandra Rizzo, Delia Preti, Rainer K. Reinscheid, Girolamo Calò, Remo Guerrini, Alfonso Carotenuto, Salvatore Pacifico, Chiara Ruzza, Antonella Ciancetta   +11 more
wiley   +1 more source

Effect of probenecid on accumulation and retention of calcein (Cal) in L. donovani isolates.

, 2013
A. Effect of probenecid on accumulation of Cal: accumulation under normal condition (hatched bar), accumulation under ATP depletion (mat bar), de-energized Cal accumulation in presence of probenecid (white dotted bar). B.
Smita Rai (459629), Shyam Sundar (58354), Neena Goyal (459632), Bhaskar (459630), Upendra Nath Dwivedi (459631), Sudhir K. Goel (125915)   +5 more
core   +1 more source

Probenecid affects muscle Ca2+ homeostasis and contraction independently from pannexin channel block

, 2023
International audienceTight control of skeletal muscle contractile activation is secured by the excitation–contraction (EC) coupling protein complex, a molecular machinery allowing the plasma membrane voltage to control the activity of the ryanodine ...
Monteiro, Laloé, Jacquemond, Vincent, Berthier, Christine, Jaque-Fernandez, Francisco, Allard, Bruno, Lafoux, Aude, Huchet, Corinne, Jaimovich, Enrique   +7 more
core   +1 more source

Retro‐Hetero‐Michael Addition Strategies in Organic Synthesis

European Journal of Organic Chemistry, Volume 29, Issue 32, 24 August 2026.
In this review, synthetic approaches to carbo‐ and heterocyclic compounds, including natural products, published in the last 15 years (2011–2025) which have either relied upon or included a retro‐hetero‐Michael addition step at any stage are discussed.
Dina Scarpi, Ernesto G. Occhiato
wiley   +1 more source

A study to determine the influence of probenecid (benemid) on the urinary excretion of androsterone [PDF]

, 1998
ThesisThe aim of this study was to determine the influence of probenecid on the urinary excretion of anabolic-androgenic steroids. Androsterone is an endogenous steroid and since it is excreted in high concentrations in urine, it was used as a ...
Kruger, Hester Susanna Lucia
core  

A stability-indicating RP-HPLC method for simultaneous estimation of sulopenem etzadroxil and probenecid in bulk drug and combined tablet dosage form

Discover Chemistry
An economical, sensitive, robust, and stability-indicating RP-HPLC method was developed for the simultaneous estimation of Sulopenem Etzadroxil and Probenecid in binary mixture and combined tablet dosage forms.
Ramreddy Godela, Krishnaphanisri Ponnekanti, Anusha Polagani   +2 more
doaj   +1 more source

Probenecid inhibits ATP-induced dye uptake in HEK-hP2X7 cells.

, 2014
(A) Ethidium+ uptake was induced in HEK-hP2X7 expressing cells by the addition of 1 mM ATP (as denoted by the arrow) in low divalent physiological solution. Control ethidium uptake to ATP is shown in black squares and ethidium uptake in the presence of 2.
Archana Bhaskaracharya (543336), Iman Jalilian (543338), Kristen K. Skarratt (543340), Phuong Dao-Ung (543337), Mari Spildrejorde (543339), Stephen J. Fuller (339832), Ronald Sluyter (543341), Leanne Stokes (543342)   +7 more
core   +1 more source

Synthesis, Characterization, and Analysis of Probenecid and Pyridine Compound Salts

Crystals
This study aimed to address the issue of the low solubility in the model drug probenecid (PRO) and its impact on bioavailability. Two salts of probenecid (PRO), 4-aminopyridine (4AMP), and 4-dimethylaminopyridine (4DAP) were synthesized and characterized
Menglong Zhang, Xinyu Hou, Fuhai Yu, Liang Zhang, Baohong Hou, Lina Zhou, Chuang Xie, Songgu Wu, Wei Chen   +8 more
doaj   +1 more source