Results 71 to 80 of about 13,492 (207)
Journal of Periodontal Research, EarlyView.This systematic review evaluated drug‐target Mendelian randomisation studies on periodontitis. Twelve studies identified host‐response‐related targets mainly involved in inflammatory, complement, and immune pathways. Although some targets were linked to existing drugs, the evidence remains preliminary and heterogeneous, requiring replication and ...
Luigi Nibali +4 more
wiley +1 more source
Transdermal delivery of probenecid: the effects of vehicles and enhancers on permeation through pig skin [PDF]
, 2010 Vehicles and enhancers effect on in vitro probenecid permeation through dermatomed abdominal pig skin was investigated. The permeability of different probenecid percentages dispersed in vehicles as vaseline, carbopol/ethanol/water and carbopol ...
Debattista, Nora B. +4 more
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Biomolecules, 2020 The relationship of uric acid with macrophages has not been fully elucidated. We investigated the effect of uric acid on the proinflammatory ability of human macrophages and then examined the possible molecular mechanism involved. Primary human monocytes
Camilo P. Martínez-Reyes +8 more
doaj +1 more source
Transplant Infectious Disease, EarlyView.Among 135 cases of post‐liver transplant HHV8 disease (4 from NSW), presentations varied, and mortality was high (44%). Donor screening was rare, and donor‐derived infection was suspected in 33%. Survival improved with mTORi, reduced immunosuppression, chemotherapy, and, for non‐KS disease, donor screening. ABSTRACT Background Human herpesvirus 8 (HHV8)
Karen M. J. Waller +12 more
wiley +1 more source
Determinants of bumetanide response in the dog: Effect of probenecid [PDF]
, 1983 The pharmacokinetics and pharmacodynamics of intravenous bumetanide (0.250 mg/kg), alone (treatment I) and after probenecid pretreatment (treatment II), were studied in four mongrel dogs.
Lau, Henry S. H., Smith, David E.
core +1 more source
Experimental Physiology, EarlyView.Abstract Fibroblast growth factor 23 (FGF23) is closely associated with atrial fibrillation (AF), yet whether it modulates sodium and calcium currents in atrial myocytes remains unclear. ETV1, a key transcription factor regulating atrial electrical conduction, might also be involved in FGF23‐mediated AF.
Qiaoting Yu +7 more
wiley +1 more source
Cobalt‐Catalyzed Radical Ligand Transfer (RLT) Enables Remote‐Markovnikov Hydroamination of Alkenes
Angewandte Chemie, Volume 138, Issue 34, 17 August 2026.A cobalt‐catalyzed remote‐Markovnikov 1,3‐hydroamination of allyl carboxylates proceeds through MHAT, 1,2‐radical acyloxy migration (1,2‐RAM), and radical ligand transfer (RLT) from a Co‐N intermediate, providing protected amino alcohols. ABSTRACT Amino alcohols are prevalent in pharmaceuticals, agrochemicals, and functional materials, yet ...
Arman Khosravi +7 more
wiley +2 more sources
Probenecid Inhibits Human Metapneumovirus (HMPV) Replication In Vitro and in BALB/c Mice
VirusesHuman metapneumovirus (HMPV) is an important cause of acute respiratory tract infection and causes significant morbidity and mortality. There is no specific antiviral drug to treat HMPV or vaccine to prevent HMPV.
Harrison C. Bergeron +4 more
doaj +1 more source
Veterinary Record Case Reports, Volume 14, Issue 4, November 2026.Summary A 16‐month‐old, male, neutered cocker spaniel developed gastrointestinal signs following ingestion of a homemade modelling dough containing cream of tartar. Blood biochemistry (29 hours post‐ingestion) showed elevated creatinine, urea and symmetric dimethylarginine (SDMA).
Fiona Adam, Nicola Bates
wiley +1 more source
Addition of probenecid to oral beta-lactam antibiotics: a systematic review and meta-analysis [PDF]
, 2022 Objective: Explore literature comparing the pharmacokinetic and clinical outcomes from addition of probenecid to oral beta-lactams. Data sources: Medline and EMBASE were searched from inception to December 2021.
Wheeler, Graham +7 more
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