Results 11 to 20 of about 10,907 (165)
Evaluation of Probenecid Against Filovirus Replication in Vero E6 Cells [PDF]
VirusesIn human and non-human primates, filoviruses, e.g., Ebolaviruses, cause severe hemorrhagic fever for which there are few therapeutic options. While there are licensed vaccines and therapeutics for Ebola virus disease, there is no approved vaccine or ...
Kendra Alfson +4 more
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Probenecid Inhibits NLRP3 Inflammasome Activity and Mitogen-Activated Protein Kinases (MAPKs) [PDF]
BiomoleculesProbenecid has long been a versatile drug in pharmacological therapies, primarily known for blocking active tubular secretion in the kidney, affecting both endogenous substances like uric acid and exogenous ones like penicillin.
Les P. Jones +4 more
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Comparative study of the effects of baicalin and probenecid on microRNA expression profiles in porcine aortic vascular endothelial cells infected by Glaesserella parasuis [PDF]
BMC Veterinary ResearchBackground Glaesserella parasuis elicits severe inflammatory responses and vascular damage, thus resulting in high mortality and morbidity in pigs; consequently, early diagnosis and treatment are critical to controlling economic losses. MicroRNAs (miRNAs)
Ling Guo +8 more
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Sulopenem Etzadroxil/Probenecid. [PDF]
Hosp PharmEach month, subscribers to The Formulary Monograph Service receive 5 to 6 well-documented monographs on drugs that are newly released or are in late phase 3 trials. The monographs are targeted to Pharmacy & Therapeutics Committees.
Baker DE, Levien TL.
europepmc +3 more sources
Correction: Neuroprotective effects of the pannexin-1 channel inhibitor: probenecid on spinal cord injury in rats [PDF]
Frontiers in Molecular NeuroscienceQi Qi +14 more
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Frontiers in Pharmacology, 2021 Objectives: Probenecid is an anion transport inhibitor, which, according to the connectivity map (CMap; a biological application database), interferes with hypoxia-induced gene expression changes in retinal vascular endothelial cells (ECs).
Jingbo Jiang +10 more
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Influence of Probenecid on the Pharmacokinetics and Pharmacodynamics of Sorafenib
Pharmaceutics, 2020 Prior studies have demonstrated an organic anion transporter 6 (OAT6)-mediated accumulation of sorafenib in keratinocytes. The OAT6 inhibitor probenecid decreases sorafenib uptake in skin and might, therefore, decrease sorafenib-induced cutaneous adverse
Koen G. A. M. Hussaarts +16 more
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Biomedicines, 2023 Probenecid is an old uricosuric agent used in clinics to treat gout and reduce the renal excretion of antibiotics. In recent years, probenecid has gained attention due to its ability to interact with membrane proteins such as TRPV2 channels, organic ...
Claudia García-Rodríguez +7 more
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Oral Probenecid for Nonhospitalized Adults with Symptomatic Mild-to-Moderate COVID-19
Viruses, 2023 Probenecid is an orally bioavailable, uricosuric agent that was first approved in 1951 for the treatment of gout, but was later found to have potent, broad-spectrum antiviral activity against several respiratory viruses including SARS-CoV-2. We conducted
David E. Martin +6 more
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Frontiers in Molecular Neuroscience, 2022 Proinflammatory immune cell subsets constitute the majority in the local microenvironment after spinal cord injury (SCI), leading to secondary pathological injury.
Qi Qi +14 more
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