Results 11 to 20 of about 18,678 (212)

Comparative study of the effects of baicalin and probenecid on microRNA expression profiles in porcine aortic vascular endothelial cells infected by Glaesserella parasuis [PDF]

BMC Veterinary Research
Background Glaesserella parasuis elicits severe inflammatory responses and vascular damage, thus resulting in high mortality and morbidity in pigs; consequently, early diagnosis and treatment are critical to controlling economic losses. MicroRNAs (miRNAs)
Ling Guo, Yaqiong Yang, Linrong Yang, Peiyan Sun, Jing He, Shulin Fu, Chun Ye, Bingbing Zong, Yinsheng Qiu   +8 more
doaj   +2 more sources

Baicalin, Amoxicillin, and Probenecid Provide Protection in Mice Against Glaesserella parasuis Challenge [PDF]

Biomolecules
Glaesserella parasuis (G. parasuis) causes Glässer’s disease and systemic inflammatory responses in the host. The currently available therapies have limited efficacy and fail to achieve a balance between anti-inflammatory and antibacterial effects.
Jingyang Li, Ronghui Luo, Yunjian Fu, Siyu Liu, Qiaoli Dong, Yamin Sun, Xinyue Tian, Yi Zhu, Peiyi Wang, Ling Guo, Qirong Lu, Chun Ye, Shulin Fu, Yinsheng Qiu   +13 more
doaj   +2 more sources

PROBENECID AND ZIDOVUDINE METABOLISM

Lancet, The, 1989
The effects of probenecid, a known inhibitor of glucuronidation, on the pharmacokinetics of zidovudine were assessed in eight subjects receiving zidovudine as treatment for human immunodeficiency virus infection. Zidovudine plasma concentrations were measured while subjects were receiving zidovudine alone, after 3 days of zidovudine plus 500 mg ...
D M, Kornhauser, B G, Petty, C W, Hendrix, A S, Woods, L J, Nerhood, J G, Bartlett, P S, Lietman   +6 more
exaly   +3 more sources

Evaluating Probenecid or Oseltamivir Inhibition of Influenza A Virus Replication Through Plaque Assay or Fluorescent Focus Assay Using Non-Structural Protein 1–H1N1 Venus Reporter Virus [PDF]

Viruses
It is essential to understand the molecular mechanisms of influenza antiviral therapeutics to evaluate their efficacy. Virus plaque assays are commonly used to assess the antiviral effects of drugs on virus replication; however, this method is labor ...
Jackelyn Murray, Aitor Nogales, Luis Martinez-Sobrido, David E. Martin, Fred D. Sancilio, Ralph A. Tripp   +5 more
doaj   +2 more sources

Sulopenem Etzadroxil/Probenecid. [PDF]

Hosp Pharm
Each month, subscribers to The Formulary Monograph Service receive 5 to 6 well-documented monographs on drugs that are newly released or are in late phase 3 trials. The monographs are targeted to Pharmacy & Therapeutics Committees.
Baker DE, Levien TL.
europepmc   +3 more sources

Colon-Specific Delivery of Probenecid Enhances Therapeutic Activity of the Uricosuric Agent Against Rat Colitis [PDF]

Pharmaceutics
Background/Objectives: Probenecid (PBN) is a uricosuric agent that facilitates the excretion of uric acid and is used to treat gout. Here, a colon-targeted prodrug of PBN was designed to facilitate repositioning as a treatment for inflammatory bowel ...
Yeonhee Jeong, Jaejeong Kim, Changyu Kang, Yunjin Jung   +3 more
doaj   +2 more sources

Correction: Neuroprotective effects of the pannexin-1 channel inhibitor: probenecid on spinal cord injury in rats [PDF]

Frontiers in Molecular Neuroscience
Qi Qi, Qi Qi, Xiao-Xuan Wang, Xiao-Xuan Wang, Jing-Lu Li, Jing-Lu Li, Yu-Qing Chen, Yu-Qing Chen, Jian-Rong Chang, Jin Xi, He-Zuo Lü, He-Zuo Lü, He-Zuo Lü, Yu-Xin Zhang, Yu-Xin Zhang   +14 more
doaj   +2 more sources

Influence of Probenecid on the Pharmacokinetics and Pharmacodynamics of Sorafenib

Pharmaceutics, 2020
Prior studies have demonstrated an organic anion transporter 6 (OAT6)-mediated accumulation of sorafenib in keratinocytes. The OAT6 inhibitor probenecid decreases sorafenib uptake in skin and might, therefore, decrease sorafenib-induced cutaneous adverse
Koen G. A. M. Hussaarts, Leni van Doorn, Karel Eechoute, Jeffrey Damman, Qiang Fu, Nadia van Doorn, Eric D. Eisenmann, Alice A. Gibson, Esther Oomen-de Hoop, Peter de Bruijn, Sharyn D. Baker, Stijn L. W. Koolen, Teun van Gelder, Roelof W. F. van Leeuwen, Ron H. J. Mathijssen, Alex Sparreboom, Sander Bins   +16 more
doaj   +1 more source

Effect of Probenecid on Endothelial Cell Growth Rate and Retinal Angiogenesis in an Oxygen-Induced Retinopathy Model

Frontiers in Pharmacology, 2021
Objectives: Probenecid is an anion transport inhibitor, which, according to the connectivity map (CMap; a biological application database), interferes with hypoxia-induced gene expression changes in retinal vascular endothelial cells (ECs).
Jingbo Jiang, Weiming Ou, Xianqiong Luo, Jianwen Xiang, Guosheng Liu, Shuiqing Huang, Hongping Li, Longkai He, Jiamin Gan, Shasha Han, Chuan Nie   +10 more
doaj   +1 more source

Probenecid, an Old Drug with Potential New Uses for Central Nervous System Disorders and Neuroinflammation

Biomedicines, 2023
Probenecid is an old uricosuric agent used in clinics to treat gout and reduce the renal excretion of antibiotics. In recent years, probenecid has gained attention due to its ability to interact with membrane proteins such as TRPV2 channels, organic ...
Claudia García-Rodríguez, Paula Mujica, Javiera Illanes-González, Araceli López, Camilo Vargas, Juan C. Sáez, Arlek González-Jamett, Álvaro O. Ardiles   +7 more
doaj   +1 more source