Results 101 to 110 of about 99,858 (332)

Local Treatment of Hand-Foot Syndrome with Uridine/Thymidine: In Vitro Appraisal on a Human Keratinocyte Cell Line HaCaT

The Scientific World Journal, 2012
5-fluorouracil (5-FU) is one of the most commonly used antineoplastic drugs in the anticancer therapy. The hand-foot (HF) syndrome (palmar-plantar erythrodysesthesia) is an adverse effect frequently related to long-term i.v. administration of 5-FU or its
J. Hartinger, P. Veselý, E. Matoušková, S. Argalacsová, L. Petruželka, I. Netíková   +5 more
doaj   +1 more source

The Mechanism of Action of Uridine Diphosphoglucose Dehydrogenase

Journal of Biological Chemistry, 1971
Abstract Uridine diphospho-α-d-galacto-hexodialdose (UDP-Gal-6-CHO) and uridine diphospho-α-d-gluco-hexodialdose (UDP-Glc-6-CHO) were produced from UDP-galactose through the use of galactose oxidase and UDP-glucose 4-epimerase. UDP-Glc-6-CHO was shown to be an intermediate in the reaction catalyzed by the enzyme UDP-glucose dehydrogenase, indicating ...
S. Kirkwood, Gary L. Nelsestuen
openaire   +3 more sources

Integrated Chemoenzymatic Synthesis of the mRNA Vaccine Building Block N1‐Methylpseudouridine Triphosphate

Angewandte Chemie International Edition, EarlyView.
Pseudouridine‐5′‐triphosphate (ΨTP) and its N1‐methylated derivative (m1ΨTP) are crucial components in mRNA vaccine technology. Here, an atom‐economic, high‐yielding biocatalytic route for ΨTP synthesis is presented. A new chemoenzymatic route for m1ΨTP synthesis was developed.
Martin Pfeiffer, Leo Krammer, Johannes Zöhrer, Rolf Breinbauer, Bernd Nidetzky   +4 more
wiley   +1 more source

The predictive value of plasma uridine for type 2 diabetes and its atherosclerotic complications

Endocrine Connections
Objective: Uridine might be a common link between pathological pathways in diabetes and cardiovascular diseases. This study aimed to investigate the predictive value of plasma uridine for type 2 diabetes (T2D) and T2D with atherosclerosis.
Yueyuan Yang, Tingting Yu, Zhili Niu, Ling Gao   +3 more
doaj   +1 more source

5-fluorouracil Toxicity Mechanism Determination in Human Keratinocytes: in vitro Study on HaCaT

Prague Medical Report, 2018
5-fluorouracil (5-FU) and capecitabine therapy is often accompanied by palmar-plantar erythrodysesthesia (PPE) which is manifestation of 5-FU toxicity in keratinocytes. The main mechanisms of 5-FU action are thymidylate synthase (TS) inhibition which can
Jan Hartinger, Pavel Veselý, Martin Šíma, Irena Netíková, Eva Matoušková, Luboš Petruželka   +5 more
doaj   +1 more source

Histochemical indications for a chemically complex signal produced by the cervical gill slit gland of the pygmy sperm whale (Kogia breviceps)

The Anatomical Record, EarlyView.
Abstract The pygmy sperm whale (Kogia breviceps) possesses an exocrine gland associated with its false gill slit pigmentation pattern. The cervical gill slit gland is a compound tubuloalveolar gland that produces a holocrine secretion and displays maturational changes in size and secretory histology. While the morphology of the cervical gill slit gland
Tiffany F. Keenan, William A. McLellan, Sentiel A. Rommel, Alexander M. Costidis, Craig A. Harms, J. G. M. Thewissen, Susan J. Rehorek, David S. Rotstein, Mark D. Gay, Alison R. Taylor, Heather N. Koopman, Ying Wang, Stephanie Kamel, D. Ann Pabst   +13 more
wiley   +1 more source

Pharmacological targets of SGLT2 inhibition on prostate cancer mediated by circulating metabolites: a drug-target Mendelian randomization study

Frontiers in Pharmacology
BackgroundThe relationship between sodium-glucose cotransporter 2 (SGLT2) inhibitors and prostate cancer is still unknown. Although these inhibitors can influence tumor glycolysis, the underlying mechanism requires further exploration.MethodsA two-sample
Yilong Lin, Yilong Lin, Yue Zhang, Songsong Wang, Lin Cao, Ruidan Zhao, Xilai Ma, Qiaolu Yang, Liyi Zhang, Qingmo Yang, Qingmo Yang   +10 more
doaj   +1 more source

Uridine prevents tamoxifen-induced liver lipid droplet accumulation

BMC Pharmacology and Toxicology, 2014
BackgroundTamoxifen, an agonist of estrogen receptor, is widely prescribed for the prevention and long-term treatment of breast cancer. A side effect of tamoxifen is fatty liver, which increases the risk for non-alcoholic fatty liver disease.
Thuc T. Le, Y. Urasaki, G. Pizzorno
semanticscholar   +1 more source

Uridine supplementation exerts anti-inflammatory and anti-fibrotic effects in an animal model of pulmonary fibrosis

Respiratory Research, 2014
RationalePulmonary fibrosis is a progressive disease with only few treatment options available at the moment. Recently, the nucleoside uridine has been shown to exert anti-inflammatory effects in different animal models, e.g.
S. Cicko, M. Grimm, Korcan Ayata, J. Beckert, A. Meyer, M. Hossfeld, G. Zissel, M. Idzko, T. Müller   +8 more
semanticscholar   +1 more source

Characterization of the pattern of development of key compounds contributing to aroma quality of chicken meat and their metabolic markers

Animal Research and One Health, EarlyView.
The graphical abstract shows the principal results of this study. Eight major aroma‐contributing compounds (nonanal, octanal, dimethyl tetrasulfide, hexanal, 1‐octen‐3‐ol, (E)‐2‐nonenal, heptanal, and (E,E)‐2,4‐decadienal) were identified by electronic nose and GC‐O‐MS analysis, and their content increased with age.
Yanke Wang, Xiaojing Liu, Yongli Wang, Zhengxiao He, Guiping Zhao, Jie Wen, Huanxian Cui   +6 more
wiley   +1 more source