Results 281 to 290 of about 99,858 (332)

From Cortisone to Enlicitide: A Journey of Synthetic Chemistry Innovations at Merck. [PDF]

J Org Chem
Campeau LC.
europepmc   +1 more source

Downregulation of O‐GlcNAcylation enhances etoposide‐induced p53‐mediated apoptosis in HepG2 human liver cancer cells

FEBS Open Bio, Volume 15, Issue 7, Page 1176-1188, July 2025.
Etoposide, a topoisomerase II inhibitor, reduces O‐GlcNAcylation in HepG2 liver cancer cells. Further inhibition of O‐GlcNAc transferase by OSMI‐1 enhanced etoposide‐induced apoptosis, lowering the IC50 for viability and increasing the EC50 for cytotoxicity.
Jaehoon Lee, Gi‐Bang Koo, Jihye Park, Byung‐Cheol Han, Mijin Kwon, Seung‐Ho Lee   +5 more
wiley   +1 more source

Correction: Schaltz et al. A Theoretical Study of Hydrogen Abstraction Reactions in Guanosine and Uridine. <i>Int. J. Mol. Sci.</i> 2023, <i>24</i>, 8192. [PDF]

Int J Mol Sci
Schaltz KF, Sauer SPA.
europepmc   +1 more source

β‐Glucuronidase‐Expressing Lactobacillus reuteri Triggers Irinotecan Enterotoxicity Through Depleting the Regenerative Epithelial Stem/Progenitor Pool

Advanced Science, Volume 12, Issue 26, July 10, 2025.
XLP mitigated CPT11 mucositis by suppressing GUS‐expressing microbes, notably L. reuteri, and diminishing bacterial GUS activity, consequently reducing SN38 accumulation to protect the intestinal epithelium. This preservation of the mucosal stem cell niche enabled rapid regeneration of secretory lineages such as mucin‐producing goblet cells, which ...
Bei Yue, Ruiyang Gao, Ling Zhao, Donghui Liu, Cheng Lv, Ziyi Wang, Fangbin Ai, Beibei Zhang, Zhilun Yu, Xiaolong Geng, Hao Wang, Kang Wang, Kaixian Chen, Chenghai Liu, Zhengtao Wang, Wei Dou   +15 more
wiley   +1 more source

Preoperative donor urinary UDP-Glc as an independent risk factor for delayed graft function. [PDF]

Front Immunol
Ma M, Han F, Leng Q, Chen X, Tang Z, Zhang J, Luo Y, Zhang Y, Huang Z, Na N.   +9 more
europepmc   +1 more source

Sortilin‐Mediated Rapid, Precise and Sustained Degradation of Membrane Proteins via mRNA‐Encoded Lysosome‐Targeting Chimera

Advanced Science, Volume 12, Issue 25, July 3, 2025.
The study identified sortilin as a promising LTR, enabling targeted degradation of oncogenic proteins through an mRNA‐encoded MedTAC strategy. In a mouse model, MedTACPTK7 reduced PTK7 by up to 80%, extended survival, and showed excellent pharmacokinetics without toxicity, providing a scalable platform for targeted therapies.
Xin Chang, Xinyu Qiu, Xiaoning Tong, Shaoju Gan, Weicheng Yi, Sitao Xie, Xiangsheng Liu, Chao Zuo, Weihong Tan   +8 more
wiley   +1 more source

Uridine-sensitized screening identifies genes and metabolic regulators of nucleotide synthesis

Strefeler A, Baker ZN, Chollet S, Guerra RM, Ivanisevic J, Gallart-Ayala H, Pagliarini DJ, Jourdain AA.   +7 more
europepmc   +1 more source

Exponential Clonal Expansion of 5-Fluorocytosine-Resistant Candida tropicalis and New Insights into Underlying Molecular Mechanisms. [PDF]

Emerg Infect Dis
Abou-Chakra N, Astvad KMT, Martinussen J, Munksgaard ASE, Arendrup MC.   +4 more
europepmc   +1 more source

HDAC6 and USP9X Control Glutamine Metabolism by Stabilizing GS to Promote Glioblastoma Tumorigenesis

Advanced Science, Volume 12, Issue 25, July 3, 2025.
Glioblastoma (GBM) growth relies on glutamine synthetase (GS), which is stabilized by histone deacetylase 6 (HDAC6) and deubiquitinated by ubiquitin‐specific peptidase 9, X‐linked (USP9X). HDAC6 promotes GS deacetylation, while USP9X removes its K48‐linked polyubiquitination, enhancing GS stability.
Go Woon Kim, Minhae Cha, Hien Thi My Ong, Jung Yoo, Yu Hyun Jeon, Sang Wu Lee, Soo Yeon Oh, Min‐Jung Kang, Youngsoo Kim, So Hee Kwon   +9 more
wiley   +1 more source

The Interaction Among Rhizosphere Soil Nutrients, Metabolites, and Microbes Determines the Productivity of Perennial Cultivated Grassland in Qinghai-Tibet Plateau. [PDF]

Ecol Evol
Zhang X, Liu Y, Cao Q, Yang Z, Yu Z, Li C, Zhang C, Dong Q.   +7 more
europepmc   +1 more source