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Uridine Kinase: Altered Enzyme with Decreased Affinities for Uridine and CTP

Archives of Biochemistry and Biophysics, 1998
Uridine kinase is the rate-limiting enzyme in the salvage pathway for uridine or cytidine of mammalian cells. Alignment of the uridine kinase sequence with other nucleoside and nucleotide kinases supports a common ancestor for all of these. Three polypeptide segments for the ATP site and three polypeptide segments for the acceptor nucleoside site have ...
P A, Ropp, T W, Traut
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Ein neuer Weg zu 3′‐Desoxy‐uridin aus Uridin

Chemische Berichte, 1968
AbstractDie Darstellung von 3′‐Desoxy‐uridin (3) aus Uridin über 1 und 2 wird beschrieben. 3 ist gegenüber saurer Hydrolyse relativ stabil. 3 hemmt in vitro weder die DNS‐ noch die RNS‐Synthese von Ehrlich‐Ascites‐Tumorzellen. Die Verbindung vermag Nucleosid‐Phosphorylasen nicht zu hemmen und wird durch diese Enzyme nicht gespalten.
Gotthard Kowollik, Peter Langen
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Feedback onhibition of uridine kinase by cytidine triphosphate and uridine triphosphate

Biochimica et Biophysica Acta (BBA) - Specialized Section on Nucleic Acids and Related Subjects, 1964
Abstract Uridine kinase was found to be the rate-limiting step in the anabolism of uridine to its successive nucleotide derivatives. This enzymatic activity was susceptible to feedback inhibition by the pyrimidine nucleoside triphosphate end-products; effective inhibition was exerted by UTP and even more strikingly by CTP.
E P, ANDERSON, R W, BROCKMAN
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Uridine diphosphate glucuronosyltransferase 1A1

Xenobiotica, 2019
The role that the phase-II reaction, glucuronidation, plays in the biotransformation of endo and xenobiotics is discussed with particular emphasis given to the UGT1A1 isoenzyme. This individual isoenzyme is responsible for both the mono and di-glucuronidation of bilirubin together with the glucuronidation of a number of xenobiotics of clinical interest
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Measurements of uridine diphosphate glucose and uridine diphosphate galactose — an appraisal

European Journal of Pediatrics, 1995
The recent disproof of a major deficiency of uridine diphosphate galactose in galactosemia should not lead investigators to assume either that enzymatic methods are unreliable for uridine sugar assays or that a defect in galactosylation in galactosemia has been excluded.
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Die Synthese der 5′‐Diphosphate von 5‐Methyl‐uridin, 5‐Hydroxymethyl‐uridin und 3.5‐Dimethyl‐uridin

Chemische Berichte, 1966
AbstractAusgehend von 2′.3′‐O‐Isopropyliden‐uridin wurden 5‐Hydroxymethyl‐, 5‐Methyl‐ und 3.5‐Dimethyl‐2′.3′‐O‐isopropyliden‐uridin in guten Ausbeuten dargestellt. Die geschützten Nucleoside wurden durch 2‐Cyan‐äthylphosphat und Dicyclohexylcarbodiimid (DCCI) phosphoryliert.
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Vascular effects of uridine and uridine nucleotides

Pharmaceutical Chemistry Journal, 1993
O. Yu. Mel'nikova, V. V. Eliseev
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Uridin-5'-triphosphat, Uridin-5'-diphosphat, Uridin-5'-monophosphat

1970
Dietrich Keppler   +2 more
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