A double-blind, randomized, comparative study of the use of a combination of uridine triphosphate trisodium, cytidine monophosphate disodium, and hydroxocobalamin, versus isolated treatment with hydroxocobalamin, in patients presenting with compressive neuralgias [PDF]
Journal of Pain Research, 2017 Henrique Goldberg,1 Marco Antonio Mibielli,2 Carlos Pereira Nunes,2 Stephanie Wrobel Goldberg,3 Luiz Buchman,4 Spyros GE Mezitis,5 Helio Rzetelna,6 Lisa Oliveira,2 Mauro Geller,2 Fernanda Wajnsztajn7 1UERJ Medical School, Rio de Janeiro, Brazil; 2UNIFESO
Goldberg H +9 more
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Effects of substituting uridine triphosphate for ATP on the crossbridge cycle of rabbit muscle
The Journal of Physiology, 2001 1. Substituting uridine triphosphate (UTP) for ATP as a substrate for rabbit skeletal myosin and actin at 4 degrees C slowed the dissociation of myosin-S1 from actin by threefold, and hydrolysis of the nucleotide by sevenfold, without a decrease in the rates of phosphate or uridine diphosphate dissociation from actomyosin. 2.
Lincoln E. Ford +2 more
semanticscholar +6 more sources
<em>Bacillus anthracis</em> Edema Factor Substrate Specificity: Evidence for New Modes of Action [PDF]
Toxins, 2012 Since the isolation of <em>Bacillus anthracis</em> exotoxins in the 1960s, the detrimental activity of edema factor (EF) was considered as adenylyl cyclase activity only.
Roland Seifert +2 more
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Contractile effects of uridine 5′‐triphosphate in the rat duodenum [PDF]
British Journal of Pharmacology, 1994 Previous studies have shown that the rat duodenum relaxes to adenosine and adenosine 5′‐triphosphate (ATP) via Pi and P2Y purinoceptors respectively, but in preliminary studies uridine 5′‐triphosphate (UTP) was found to contract this tissue. The non‐selective P2 antagonist suramin and a number of nucleotides were therefore used to investigate this ...
C. R. Johnson, Susanna M.O. Hourani
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Development and application of an uncapped mRNA platform [PDF]
Annals of MedicineBackground A novel uncapped mRNA platform was developed.Methods Five lipid nanoparticle (LNP)-encapsulated mRNA constructs were made to evaluate several aspects of our platform, including transfection efficiency and durability in vitro and in vivo and ...
Xiaodi Zheng +21 more
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Modulators of Ion Transport in Nasal Polyps: An Measurement of Short-Circuit Current [PDF]
Clinical and Experimental Otorhinolaryngology, 2008 ObjectivesTo examine possible modulators of the ion transport through the apical membrane of the nasal polyps.MethodsThe study was conducted using the freshly-excised nasal polyps from the patients with chronic sinusitis.
Jun Ho Lee +3 more
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Depletion of cytidine triphosphate as a consequence of cellular uridine triphosphate deficiency [PDF]
FEBS Letters, 1979 The synthesis of CTP from UTP, catalyzed by CTP synthetase (EC 6.3.4.2), would imply that severe UTP deficiency causes a reduction of cellular CTP synthesis followed by a decrease in CTP pools. By contrast, UTP depletion induced by D-galactosamine in rat liver in vivo has been shown to be associated with a 2-fold increase in the hepatic content of CTP [
Hanspeter Henninger +4 more
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ENZYMATIC AMINATION OF URIDINE TRIPHOSPHATE TO CYTIDINE TRIPHOSPHATE [PDF]
Journal of Biological Chemistry, 1956 Irving Lieberman
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Uridine 5′-Triphosphate Stimulates Alveolar Fluid Clearance in the Isolated Rat Lungs
Journal of Pharmacological Sciences, 2004 Uridine 5′-triphosphate (UTP) increases chloride secretion followed by fluid movement into the proximal airspaces. However, little is known about whether UTP affects fluid movement in the distal airspaces.
Tsutomu Sakuma +5 more
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Arabian Journal of Chemistry, 2022 RNA plays a crucial role in biochemical processes. RNAs with abasic sites (AP-RNA), as one of RNA lesions, will cause serious negative consequences. Efficient and sensitive detection of AP-RNA deserves but does not receive enough attention. Water-soluble
Jie Zhao, Yan Gong
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