A double-blind, randomized, comparative study of the use of a combination of uridine triphosphate trisodium, cytidine monophosphate disodium, and hydroxocobalamin, versus isolated treatment with hydroxocobalamin, in patients presenting with compressive neuralgias [PDF]
Journal of Pain Research, 2017 Henrique Goldberg,1 Marco Antonio Mibielli,2 Carlos Pereira Nunes,2 Stephanie Wrobel Goldberg,3 Luiz Buchman,4 Spyros GE Mezitis,5 Helio Rzetelna,6 Lisa Oliveira,2 Mauro Geller,2 Fernanda Wajnsztajn7 1UERJ Medical School, Rio de Janeiro, Brazil; 2UNIFESO
Goldberg H +9 more
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Uridine Triphosphate Thio Analogues Inhibit Platelet P2Y12 Receptor and Aggregation. [PDF]
Int J Mol Sci, 2017 Platelet P2Y12 is an important adenosine diphosphate (ADP) receptor that is involved in agonist-induced platelet aggregation and is a valuable target for the development of anti-platelet drugs. Here we characterise the effects of thio analogues of uridine triphosphate (UTP) on ADP-induced platelet aggregation.
Gündüz D +7 more
europepmc +7 more sources
Regulation of the osteogenic and adipogenic differentiation of bone marrow-derived stromal cells by extracellular uridine triphosphate: The role of P2Y2 receptor and ERK1/2 signaling. [PDF]
Int J Mol Med, 2016 An imbalance in the osteogenesis and adipogenesis of bone marrow-derived stromal cells (BMSCs) is a crucial pathological factor in the development of osteoporosis.
Li W +5 more
europepmc +4 more sources
Uridine 5'-triphosphate promotes in vitro Schwannoma cell migration through matrix metalloproteinase-2 activation. [PDF]
PLoS ONE, 2014 In response to peripheral nerve injury, Schwann cells adopt a migratory phenotype and modify the extracellular matrix to make it permissive for cell migration and axonal re-growth.
Aloa Lamarca +7 more
doaj +4 more sources
Modulation of Rat Tissue Galactose-1-Phosphate Uridyltransferase by Uridine and Uridine Triphosphate [PDF]
Pediatric Research, 1991 Uridine-containing sugar nucleotides, uridine diphosphate (UDP)-glucose and UDPgalactose are important intermediates in galactose metabolism, and tissue UDPgalactose may be a salient factor in the etiology of the long-term clinical manifestations of patients with galactose-1-phosphate uridyltransferase deficient galactosemia.
S, Rogers, S, Segal
semanticscholar +4 more sources
Do Cyclosporine A, an IL-1 Receptor Antagonist, Uridine Triphosphate, Rebamipide, and/or Bimatoprost Regulate Human Meibomian Gland Epithelial Cells? [PDF]
Invest Ophthalmol Vis Sci, 2016 Purpose Researchers have hypothesized that treatment with cyclosporine A (CyA), interleukin-1 receptor antagonists (IL-1RA; e.g., anakinra), P2Y2 receptor agonists (e.g., uridine triphosphate; UTP), and rebamipide may alleviate human meibomian gland ...
Kam WR, Liu Y, Ding J, Sullivan DA.
europepmc +2 more sources
<em>Bacillus anthracis</em> Edema Factor Substrate Specificity: Evidence for New Modes of Action [PDF]
Toxins, 2012 Since the isolation of <em>Bacillus anthracis</em> exotoxins in the 1960s, the detrimental activity of edema factor (EF) was considered as adenylyl cyclase activity only.
Roland Seifert +2 more
doaj +4 more sources
4-Alkyloxyimino Derivatives of Uridine-5′-triphosphate: Distal Modification of Potent Agonists as a Strategy for Molecular Probes of P2Y2, P2Y4, and P2Y6Receptors [PDF]
Journal of Medicinal Chemistry, 2014 Extended N4-(3-arylpropyl)oxy derivatives of uridine-5′-triphosphate were synthesized and potently stimulated phospholipase C stimulation in astrocytoma cells expressing G protein-coupled human (h) P2Y receptors (P2YRs) activated by UTP (P2Y2/4R) or UDP (
P. Suresh Jayasekara +7 more
openalex +2 more sources
Depletion of cytidine triphosphate as a consequence of cellular uridine triphosphate deficiency [PDF]
FEBS Letters, 1979 The synthesis of CTP from UTP, catalyzed by CTP synthetase (EC 6.3.4.2), would imply that severe UTP deficiency causes a reduction of cellular CTP synthesis followed by a decrease in CTP pools. By contrast, UTP depletion induced by D-galactosamine in rat liver in vivo has been shown to be associated with a 2-fold increase in the hepatic content of CTP [
Henninger, Hanspeter +4 more
openaire +3 more sources
Uridine 5′-Triphosphate Stimulates Alveolar Fluid Clearance in the Isolated Rat Lungs
Journal of Pharmacological Sciences, 2004 Uridine 5′-triphosphate (UTP) increases chloride secretion followed by fluid movement into the proximal airspaces. However, little is known about whether UTP affects fluid movement in the distal airspaces.
Tsutomu Sakuma +5 more
doaj +3 more sources