Results 91 to 100 of about 126,321 (267)

Filamentation and inhibition of prokaryotic CTP synthase with ligands

mLife
Cytidine triphosphate synthase (CTPS) plays a pivotal role in the de novo synthesis of cytidine triphosphate (CTP), a fundamental building block for RNA and DNA that is essential for life.
Chenjun Guo, Zixuan Wang, Ji‐Long Liu
doaj   +1 more source

Cell‐specific genome‐scale metabolic modeling of SARS‐CoV‐2‐infected lung to identify antiviral enzymes

FEBS Open Bio, 2023
Computational systems biology plays a key role in the discovery of suitable antiviral targets. We designed a cell‐specific, constraint‐based modeling technique for severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2)‐infected lungs.
Ke‐Lin Chen, Feng‐Sheng Wang
doaj   +1 more source

Enzymatic phosphorylation of uridine and cytidine using calcium‐based dual‐enzyme nanoflowers

Food Bioengineering
Nucleotides, such as uridine 5′‐monophosphate (5′‐UMP) and cytidine 5′‐monophosphate (5′‐CMP), are heavily demanded as food additives, dietary supplements, and medicinal intermediates.
Ziye Zhao, Ning Nie, Xinwei Li, Ye Shi, Xudong Liu, Yifei Zhang   +5 more
doaj   +1 more source

The structural basis of ATP as an allosteric modulator.

PLoS Computational Biology, 2014
Adenosine-5'-triphosphate (ATP) is generally regarded as a substrate for energy currency and protein modification. Recent findings uncovered the allosteric function of ATP in cellular signal transduction but little is understood about this critical ...
Shaoyong Lu, Wenkang Huang, Qi Wang, Qiancheng Shen, Shuai Li, Ruth Nussinov, Jian Zhang   +6 more
doaj   +1 more source

Regulatory mechanism of O‐linked N‐acetylglucosamine protein modification on autophagy in cancer

Clinical and Translational Medicine, Volume 16, Issue 1, January 2026.
O‐GlcNAcylation serves as a nutrient and stress sensor that dynamically regulates autophagy at multiple stages in cancer cells. It fine‐tunes autophagy initiation, maturation and fusion by modifying key proteins such as ULK1, ATG4B and SNAP‐29. Context‐dependent O‐GlcNAcylation promotes tumour adaptation and therapy resistance via autophagy remodelling.
Yizhan Li, Ling Gao, Shaoming Li, Jingjing Zheng, Keqian Zhi, Wenhao Ren   +5 more
wiley   +1 more source

Comparison of Endothelium-Related Responses to Nucleotides of Dog and Monkey Cerebral Arteries

Journal of Pharmacological Sciences, 2010
We compared mechanical responses to uridine-5′triphosphate (UTP) and 2-(methylthio)adenosine-5′diphosphate (2MeSADP) of cerebral arteries isolated from dogs and monkeys. In the dog, UTP induced endothelium-independent contraction, whereas 2MeSADP induced
Ayman Geddawy, Takashi Shimosato, Masashi Tawa, Takeshi Imamura, Tomio Okamura   +4 more
doaj   +1 more source

Fish Oil Ameliorates Glycolipid Metabolism Disorders Induced by Long‐Term Potato Chip Diet Through Gut‐Liver Axis

Food Frontiers, Volume 7, Issue 1, January 2026.
Fried potato consumption is increasingly associated with metabolic disorders, yet preventive strategies remain poorly understood. In a 13‐week mouse model, long‐term potato chip intake induced significant glycolipid metabolic disturbances and tissue damage, which were ameliorated by fish oil supplementation through modulation of inflammation, hepatic ...
Xuzhi Wan, Xiaoran Song, Yingyu Huang, Qi Lu, Denghui Meng, Xiaohui Liu, Anli Wang, Pan Zhuang, Yilei Fan, Jingjing Jiao, Yu Zhang   +10 more
wiley   +1 more source

Design of Potential Anti-Leishmanial Pharmacophores via In Silico Drug Repurposing

Journal of Ardabil University of Medical Sciences, 2020
Background & objectives: Drug-repurposing is the study on application of existing drugs for treatment or control of other diseases. Major advantage of the technique relies on a nominated drug molecule that is applied for pharmacodynamics optimization due
Sana Ahdeno, Nima Razaghi-Asl, Behnam Mohammadi-ghalehbin   +2 more
doaj  

Evaluation of the Pharmacokinetics, Disposition, and Metabolism of Miricorilant, a Novel Glucocorticoid Receptor Modulator for the Treatment of Metabolic Dysfunction‐Associated Steatohepatitis in Nonclinical and Clinical Studies

The Journal of Clinical Pharmacology, Volume 66, Issue 1, January 2026.
Abstract Miricorilant is a novel selective glucocorticoid receptor (GR) modulator with mixed agonist/antagonist effects at the GR and modest antagonism at the mineralocorticoid receptor that is being developed for the treatment of metabolic dysfunction‐associated steatohepatitis.
Hazel J. Hunt, Kirsteen M. Donaldson, Jeevan R. Kunta, Joseph M. Custodio   +3 more
wiley   +1 more source

The Expanding Family of Bone Marrow Homing Factors for Hematopoietic Stem Cells: Stromal Derived Factor 1 Is Not the Only Player in the Game

The Scientific World Journal, 2012
The α-chemokine stromal derived factor 1 (SDF-1), which binds to the CXCR4 and CXCR7 receptors, directs migration and homing of CXCR4+ hematopoietic stem/progenitor cells (HSPCs) to bone marrow (BM) and plays a crucial role in retention of these cells in
Mariusz Z. Ratajczak, ChiHwa Kim, Anna Janowska-Wieczorek, Janina Ratajczak   +3 more
doaj   +1 more source